The association between detection the presence of KRAS mutations in tumors and circulating tumor cells from patients with colorectal cancer
In 40 patients with newly diagnosed colorectal cancer identify circulating tumor cells the Veridex CellSearch system. In the tissue of the tumor was determined by the presence of KRAS mutations for Real-Time qPCR technique. Was found a connection of an elevated number of CTCS in the venous blood wit...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
Ministry of Healthcare of the Russian Federation. “Kuban State Medical University”
2016-02-01
|
| Series: | Кубанский научный медицинский вестник |
| Subjects: | |
| Online Access: | https://ksma.elpub.ru/jour/article/view/453 |
| _version_ | 1826568844775260160 |
|---|---|
| author | O. I. Kit O. V. Nistratova I. A. Novikova D. I. Vodolazhsky E. A. Nikipelova E. M. Nepomnyashchaya E. P. Uljanova E. N. Oleinikova |
| author_facet | O. I. Kit O. V. Nistratova I. A. Novikova D. I. Vodolazhsky E. A. Nikipelova E. M. Nepomnyashchaya E. P. Uljanova E. N. Oleinikova |
| author_sort | O. I. Kit |
| collection | DOAJ |
| description | In 40 patients with newly diagnosed colorectal cancer identify circulating tumor cells the Veridex CellSearch system. In the tissue of the tumor was determined by the presence of KRAS mutations for Real-Time qPCR technique. Was found a connection of an elevated number of CTCS in the venous blood with the presence of tumor mutations in the KRAS gene. In patients with high levels of CTCS and the presence of mutations, earlier developed distant metastases. |
| first_indexed | 2024-03-07T21:49:39Z |
| format | Article |
| id | doaj.art-983280959afe4285b65441dcf698b733 |
| institution | Directory Open Access Journal |
| issn | 1608-6228 2541-9544 |
| language | Russian |
| last_indexed | 2025-03-14T11:29:54Z |
| publishDate | 2016-02-01 |
| publisher | Ministry of Healthcare of the Russian Federation. “Kuban State Medical University” |
| record_format | Article |
| series | Кубанский научный медицинский вестник |
| spelling | doaj.art-983280959afe4285b65441dcf698b7332025-03-02T10:05:26ZrusMinistry of Healthcare of the Russian Federation. “Kuban State Medical University”Кубанский научный медицинский вестник1608-62282541-95442016-02-0117073453The association between detection the presence of KRAS mutations in tumors and circulating tumor cells from patients with colorectal cancerO. I. Kit0O. V. Nistratova1I. A. Novikova2D. I. Vodolazhsky3E. A. Nikipelova4E. M. Nepomnyashchaya5E. P. Uljanova6E. N. Oleinikova7Rostov research institute of oncologyRostov research institute of oncologyRostov research institute of oncologyRostov research institute of oncologyRostov research institute of oncologyRostov research institute of oncologyRostov research institute of oncologyRostov research institute of oncologyIn 40 patients with newly diagnosed colorectal cancer identify circulating tumor cells the Veridex CellSearch system. In the tissue of the tumor was determined by the presence of KRAS mutations for Real-Time qPCR technique. Was found a connection of an elevated number of CTCS in the venous blood with the presence of tumor mutations in the KRAS gene. In patients with high levels of CTCS and the presence of mutations, earlier developed distant metastases.https://ksma.elpub.ru/jour/article/view/453колоректальный ракциркулирующие опухолевые клеткиkras-мутацииcolorectal cancercirculating tumor cellskras mutations |
| spellingShingle | O. I. Kit O. V. Nistratova I. A. Novikova D. I. Vodolazhsky E. A. Nikipelova E. M. Nepomnyashchaya E. P. Uljanova E. N. Oleinikova The association between detection the presence of KRAS mutations in tumors and circulating tumor cells from patients with colorectal cancer Кубанский научный медицинский вестник колоректальный рак циркулирующие опухолевые клетки kras-мутации colorectal cancer circulating tumor cells kras mutations |
| title | The association between detection the presence of KRAS mutations in tumors and circulating tumor cells from patients with colorectal cancer |
| title_full | The association between detection the presence of KRAS mutations in tumors and circulating tumor cells from patients with colorectal cancer |
| title_fullStr | The association between detection the presence of KRAS mutations in tumors and circulating tumor cells from patients with colorectal cancer |
| title_full_unstemmed | The association between detection the presence of KRAS mutations in tumors and circulating tumor cells from patients with colorectal cancer |
| title_short | The association between detection the presence of KRAS mutations in tumors and circulating tumor cells from patients with colorectal cancer |
| title_sort | association between detection the presence of kras mutations in tumors and circulating tumor cells from patients with colorectal cancer |
| topic | колоректальный рак циркулирующие опухолевые клетки kras-мутации colorectal cancer circulating tumor cells kras mutations |
| url | https://ksma.elpub.ru/jour/article/view/453 |
| work_keys_str_mv | AT oikit theassociationbetweendetectionthepresenceofkrasmutationsintumorsandcirculatingtumorcellsfrompatientswithcolorectalcancer AT ovnistratova theassociationbetweendetectionthepresenceofkrasmutationsintumorsandcirculatingtumorcellsfrompatientswithcolorectalcancer AT ianovikova theassociationbetweendetectionthepresenceofkrasmutationsintumorsandcirculatingtumorcellsfrompatientswithcolorectalcancer AT divodolazhsky theassociationbetweendetectionthepresenceofkrasmutationsintumorsandcirculatingtumorcellsfrompatientswithcolorectalcancer AT eanikipelova theassociationbetweendetectionthepresenceofkrasmutationsintumorsandcirculatingtumorcellsfrompatientswithcolorectalcancer AT emnepomnyashchaya theassociationbetweendetectionthepresenceofkrasmutationsintumorsandcirculatingtumorcellsfrompatientswithcolorectalcancer AT epuljanova theassociationbetweendetectionthepresenceofkrasmutationsintumorsandcirculatingtumorcellsfrompatientswithcolorectalcancer AT enoleinikova theassociationbetweendetectionthepresenceofkrasmutationsintumorsandcirculatingtumorcellsfrompatientswithcolorectalcancer AT oikit associationbetweendetectionthepresenceofkrasmutationsintumorsandcirculatingtumorcellsfrompatientswithcolorectalcancer AT ovnistratova associationbetweendetectionthepresenceofkrasmutationsintumorsandcirculatingtumorcellsfrompatientswithcolorectalcancer AT ianovikova associationbetweendetectionthepresenceofkrasmutationsintumorsandcirculatingtumorcellsfrompatientswithcolorectalcancer AT divodolazhsky associationbetweendetectionthepresenceofkrasmutationsintumorsandcirculatingtumorcellsfrompatientswithcolorectalcancer AT eanikipelova associationbetweendetectionthepresenceofkrasmutationsintumorsandcirculatingtumorcellsfrompatientswithcolorectalcancer AT emnepomnyashchaya associationbetweendetectionthepresenceofkrasmutationsintumorsandcirculatingtumorcellsfrompatientswithcolorectalcancer AT epuljanova associationbetweendetectionthepresenceofkrasmutationsintumorsandcirculatingtumorcellsfrompatientswithcolorectalcancer AT enoleinikova associationbetweendetectionthepresenceofkrasmutationsintumorsandcirculatingtumorcellsfrompatientswithcolorectalcancer |