XBP1 Modulates the Aging Cardiorenal System by Regulating Oxidative Stress
X-box binding protein 1 (XBP1) is a unique basic-region leucine zipper (bZIP) transcription factor. Over recent years, the powerful biological functions of XBP1 in oxidative stress have been gradually revealed. When the redox balance remains undisturbed, oxidative stress plays a role in physiologica...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-10-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/12/11/1933 |
| _version_ | 1797460411260338176 |
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| author | Ji Zhang Yuanyuan Zhao Nianqiao Gong |
| author_facet | Ji Zhang Yuanyuan Zhao Nianqiao Gong |
| author_sort | Ji Zhang |
| collection | DOAJ |
| description | X-box binding protein 1 (XBP1) is a unique basic-region leucine zipper (bZIP) transcription factor. Over recent years, the powerful biological functions of XBP1 in oxidative stress have been gradually revealed. When the redox balance remains undisturbed, oxidative stress plays a role in physiological adaptations and signal transduction. However, during the aging process, increased cellular senescence and reduced levels of endogenous antioxidants cause an oxidative imbalance in the cardiorenal system. Recent studies from our laboratory and others have indicated that these age-related cardiorenal diseases caused by oxidative stress are guided and controlled by a versatile network composed of diversified XBP1 pathways. In this review, we describe the mechanisms that link XBP1 and oxidative stress in a range of cardiorenal disorders, including mitochondrial instability, inflammation, and alterations in neurohumoral drive. Furthermore, we propose that differing degrees of XBP1 activation may cause beneficial or harmful effects in the cardiorenal system. Gaining a comprehensive understanding of how XBP1 exerts influence on the aging cardiorenal system by regulating oxidative stress will enhance our ability to provide new directions and strategies for cardiovascular and renal safety outcomes. |
| first_indexed | 2024-03-09T17:04:41Z |
| format | Article |
| id | doaj.art-9832e3398a7f482b83d4012fad5708e7 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-09T17:04:41Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-9832e3398a7f482b83d4012fad5708e72023-11-24T14:25:41ZengMDPI AGAntioxidants2076-39212023-10-011211193310.3390/antiox12111933XBP1 Modulates the Aging Cardiorenal System by Regulating Oxidative StressJi Zhang0Yuanyuan Zhao1Nianqiao Gong2Anhui Province Key Laboratory of Genitourinary Diseases, Department of Urology, The First Affiliated Hospital of Anhui Medical University, Institute of Urology, Anhui Medical University, Hefei 230022, ChinaKey Laboratory of Organ Transplantation of Ministry of Education, Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, National Health Commission and Chinese Academy of Medical Sciences, Huazhong University of Science and Technology, Wuhan 430030, ChinaKey Laboratory of Organ Transplantation of Ministry of Education, Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, National Health Commission and Chinese Academy of Medical Sciences, Huazhong University of Science and Technology, Wuhan 430030, ChinaX-box binding protein 1 (XBP1) is a unique basic-region leucine zipper (bZIP) transcription factor. Over recent years, the powerful biological functions of XBP1 in oxidative stress have been gradually revealed. When the redox balance remains undisturbed, oxidative stress plays a role in physiological adaptations and signal transduction. However, during the aging process, increased cellular senescence and reduced levels of endogenous antioxidants cause an oxidative imbalance in the cardiorenal system. Recent studies from our laboratory and others have indicated that these age-related cardiorenal diseases caused by oxidative stress are guided and controlled by a versatile network composed of diversified XBP1 pathways. In this review, we describe the mechanisms that link XBP1 and oxidative stress in a range of cardiorenal disorders, including mitochondrial instability, inflammation, and alterations in neurohumoral drive. Furthermore, we propose that differing degrees of XBP1 activation may cause beneficial or harmful effects in the cardiorenal system. Gaining a comprehensive understanding of how XBP1 exerts influence on the aging cardiorenal system by regulating oxidative stress will enhance our ability to provide new directions and strategies for cardiovascular and renal safety outcomes.https://www.mdpi.com/2076-3921/12/11/1933XBP1agingcardiorenal systemoxidative stress |
| spellingShingle | Ji Zhang Yuanyuan Zhao Nianqiao Gong XBP1 Modulates the Aging Cardiorenal System by Regulating Oxidative Stress Antioxidants XBP1 aging cardiorenal system oxidative stress |
| title | XBP1 Modulates the Aging Cardiorenal System by Regulating Oxidative Stress |
| title_full | XBP1 Modulates the Aging Cardiorenal System by Regulating Oxidative Stress |
| title_fullStr | XBP1 Modulates the Aging Cardiorenal System by Regulating Oxidative Stress |
| title_full_unstemmed | XBP1 Modulates the Aging Cardiorenal System by Regulating Oxidative Stress |
| title_short | XBP1 Modulates the Aging Cardiorenal System by Regulating Oxidative Stress |
| title_sort | xbp1 modulates the aging cardiorenal system by regulating oxidative stress |
| topic | XBP1 aging cardiorenal system oxidative stress |
| url | https://www.mdpi.com/2076-3921/12/11/1933 |
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