Effects of dexamethasone on TNF-alpha-induced release of cytokines from purified human blood eosinophils
<p>Summary</p> <p>Background</p> <p>TNF-alpha is an important mediator in allergy also for its effects on eosinophils.</p> <p>Methods</p> <p>The effect of dexamethasone on TNF-alpha induced eosinophils survival, degranulation (ECP), cytokines rel...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2005-04-01
|
| Series: | Clinical and Molecular Allergy |
| Subjects: | |
| Online Access: | http://www.clinicalmolecularallergy.com/content/3/1/5 |
| _version_ | 1818825066485383168 |
|---|---|
| author | Fattah Dilniya Smith Susan J Temkin Vladislav Puxeddu Ilaria Uings Iain Ray Keith P Levi-Schaffer Francesca |
| author_facet | Fattah Dilniya Smith Susan J Temkin Vladislav Puxeddu Ilaria Uings Iain Ray Keith P Levi-Schaffer Francesca |
| author_sort | Fattah Dilniya |
| collection | DOAJ |
| description | <p>Summary</p> <p>Background</p> <p>TNF-alpha is an important mediator in allergy also for its effects on eosinophils.</p> <p>Methods</p> <p>The effect of dexamethasone on TNF-alpha induced eosinophils survival, degranulation (ECP), cytokines release (IL-8, GM-CSF) and adhesion to VCAM-1, ICAM-1 and IgG coated wells (EPO release) were evaluated.</p> <p>Results</p> <p>The drug inhibited IL-8 and GM-CSF production, but not viability, degranulation or adhesion in human peripheral blood eosinophils.</p> <p>Conclusion</p> <p>These results indicate that part of the activity of glucocorticosteroids on eosinophils may be mediated by their ability to inhibit cytokine secretion that in turn is important for the perpetuation of the allergic inflammation.</p> |
| first_indexed | 2024-12-19T00:05:51Z |
| format | Article |
| id | doaj.art-98332df738ed49a0828868bb6f06d6b8 |
| institution | Directory Open Access Journal |
| issn | 1476-7961 |
| language | English |
| last_indexed | 2024-12-19T00:05:51Z |
| publishDate | 2005-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Clinical and Molecular Allergy |
| spelling | doaj.art-98332df738ed49a0828868bb6f06d6b82022-12-21T20:46:14ZengBMCClinical and Molecular Allergy1476-79612005-04-0131510.1186/1476-7961-3-5Effects of dexamethasone on TNF-alpha-induced release of cytokines from purified human blood eosinophilsFattah DilniyaSmith Susan JTemkin VladislavPuxeddu IlariaUings IainRay Keith PLevi-Schaffer Francesca<p>Summary</p> <p>Background</p> <p>TNF-alpha is an important mediator in allergy also for its effects on eosinophils.</p> <p>Methods</p> <p>The effect of dexamethasone on TNF-alpha induced eosinophils survival, degranulation (ECP), cytokines release (IL-8, GM-CSF) and adhesion to VCAM-1, ICAM-1 and IgG coated wells (EPO release) were evaluated.</p> <p>Results</p> <p>The drug inhibited IL-8 and GM-CSF production, but not viability, degranulation or adhesion in human peripheral blood eosinophils.</p> <p>Conclusion</p> <p>These results indicate that part of the activity of glucocorticosteroids on eosinophils may be mediated by their ability to inhibit cytokine secretion that in turn is important for the perpetuation of the allergic inflammation.</p>http://www.clinicalmolecularallergy.com/content/3/1/5TNF-αeosinophilsdexamethasoneallergic inflammationcytokine |
| spellingShingle | Fattah Dilniya Smith Susan J Temkin Vladislav Puxeddu Ilaria Uings Iain Ray Keith P Levi-Schaffer Francesca Effects of dexamethasone on TNF-alpha-induced release of cytokines from purified human blood eosinophils Clinical and Molecular Allergy TNF-α eosinophils dexamethasone allergic inflammation cytokine |
| title | Effects of dexamethasone on TNF-alpha-induced release of cytokines from purified human blood eosinophils |
| title_full | Effects of dexamethasone on TNF-alpha-induced release of cytokines from purified human blood eosinophils |
| title_fullStr | Effects of dexamethasone on TNF-alpha-induced release of cytokines from purified human blood eosinophils |
| title_full_unstemmed | Effects of dexamethasone on TNF-alpha-induced release of cytokines from purified human blood eosinophils |
| title_short | Effects of dexamethasone on TNF-alpha-induced release of cytokines from purified human blood eosinophils |
| title_sort | effects of dexamethasone on tnf alpha induced release of cytokines from purified human blood eosinophils |
| topic | TNF-α eosinophils dexamethasone allergic inflammation cytokine |
| url | http://www.clinicalmolecularallergy.com/content/3/1/5 |
| work_keys_str_mv | AT fattahdilniya effectsofdexamethasoneontnfalphainducedreleaseofcytokinesfrompurifiedhumanbloodeosinophils AT smithsusanj effectsofdexamethasoneontnfalphainducedreleaseofcytokinesfrompurifiedhumanbloodeosinophils AT temkinvladislav effectsofdexamethasoneontnfalphainducedreleaseofcytokinesfrompurifiedhumanbloodeosinophils AT puxedduilaria effectsofdexamethasoneontnfalphainducedreleaseofcytokinesfrompurifiedhumanbloodeosinophils AT uingsiain effectsofdexamethasoneontnfalphainducedreleaseofcytokinesfrompurifiedhumanbloodeosinophils AT raykeithp effectsofdexamethasoneontnfalphainducedreleaseofcytokinesfrompurifiedhumanbloodeosinophils AT levischafferfrancesca effectsofdexamethasoneontnfalphainducedreleaseofcytokinesfrompurifiedhumanbloodeosinophils |