Robotic‐assisted bronchoscopy for the diagnosis of peripheral pulmonary lesions: A systematic review and meta‐analysis
Abstract Robotic‐assisted bronchoscopy (RAB) is a newly developed bronchoscopic technique for the diagnosis of peripheral pulmonary lesions (PPLs). The objective of this meta‐analysis was to analyze the diagnostic yield and safety of RAB in patients with PPLs. Five databases (PubMed, Embase, Web of...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2024-03-01
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| Series: | Thoracic Cancer |
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| Online Access: | https://doi.org/10.1111/1759-7714.15229 |
| _version_ | 1797277164190564352 |
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| author | Chunxi Zhang Fangfang Xie Runchang Li Ningxin Cui Felix J. F. Herth Jiayuan Sun |
| author_facet | Chunxi Zhang Fangfang Xie Runchang Li Ningxin Cui Felix J. F. Herth Jiayuan Sun |
| author_sort | Chunxi Zhang |
| collection | DOAJ |
| description | Abstract Robotic‐assisted bronchoscopy (RAB) is a newly developed bronchoscopic technique for the diagnosis of peripheral pulmonary lesions (PPLs). The objective of this meta‐analysis was to analyze the diagnostic yield and safety of RAB in patients with PPLs. Five databases (PubMed, Embase, Web of Science, CENTRAL, and ClinicalTrials.gov) were searched from inception to April 2023. Two independent investigators screened retrieved articles, extracted data, and assessed the study quality. The pooled diagnostic yield and complication rate were estimated. Subgroup analysis was used to explore potential sources of heterogeneity. Publication bias was assessed using funnel plots and the Egger test. Sensitivity analysis was also conducted to assess the robustness of the synthesized results. A total of 725 lesions from 10 studies were included in this meta‐analysis. No publication bias was found. Overall, RAB had a pooled diagnostic yield of 80.4% (95% CI: 75.7%–85.1%). Lesion size of >30 mm, presence of a bronchus sign, and a concentric radial endobronchial ultrasound view were associated with a statistically significantly higher diagnostic yield. Heterogeneity exploration showed that studies using cryoprobes reported better yields than those without cryoprobes (90.0%, 95% CI: 83.2%–94.7% vs. 79.0%, 95% CI: 75.8%–82.2%, p < 0.01). The pooled complication rate was 3.0% (95% CI: 1.6%–4.4%). In conclusion, RAB is an effective and safe technique for PPLs diagnosis. Further high‐quality prospective studies still need to be conducted. |
| first_indexed | 2024-03-07T15:43:45Z |
| format | Article |
| id | doaj.art-98355567eaf842f080c4d4018fed0786 |
| institution | Directory Open Access Journal |
| issn | 1759-7706 1759-7714 |
| language | English |
| last_indexed | 2024-03-07T15:43:45Z |
| publishDate | 2024-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Thoracic Cancer |
| spelling | doaj.art-98355567eaf842f080c4d4018fed07862024-03-05T06:18:18ZengWileyThoracic Cancer1759-77061759-77142024-03-0115750551210.1111/1759-7714.15229Robotic‐assisted bronchoscopy for the diagnosis of peripheral pulmonary lesions: A systematic review and meta‐analysisChunxi Zhang0Fangfang Xie1Runchang Li2Ningxin Cui3Felix J. F. Herth4Jiayuan Sun5Department of Respiratory Endoscopy, Department of Respiratory and Critical Care Medicine Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine Shanghai ChinaDepartment of Respiratory Endoscopy, Department of Respiratory and Critical Care Medicine Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine Shanghai ChinaDepartment of Respiratory Endoscopy, Department of Respiratory and Critical Care Medicine Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine Shanghai ChinaDepartment of Respiratory Endoscopy, Department of Respiratory and Critical Care Medicine Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine Shanghai ChinaDepartment of Pneumology and Critical Care Medicine, Thoraxklinik University of Heidelberg Heidelberg GermanyDepartment of Respiratory Endoscopy, Department of Respiratory and Critical Care Medicine Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine Shanghai ChinaAbstract Robotic‐assisted bronchoscopy (RAB) is a newly developed bronchoscopic technique for the diagnosis of peripheral pulmonary lesions (PPLs). The objective of this meta‐analysis was to analyze the diagnostic yield and safety of RAB in patients with PPLs. Five databases (PubMed, Embase, Web of Science, CENTRAL, and ClinicalTrials.gov) were searched from inception to April 2023. Two independent investigators screened retrieved articles, extracted data, and assessed the study quality. The pooled diagnostic yield and complication rate were estimated. Subgroup analysis was used to explore potential sources of heterogeneity. Publication bias was assessed using funnel plots and the Egger test. Sensitivity analysis was also conducted to assess the robustness of the synthesized results. A total of 725 lesions from 10 studies were included in this meta‐analysis. No publication bias was found. Overall, RAB had a pooled diagnostic yield of 80.4% (95% CI: 75.7%–85.1%). Lesion size of >30 mm, presence of a bronchus sign, and a concentric radial endobronchial ultrasound view were associated with a statistically significantly higher diagnostic yield. Heterogeneity exploration showed that studies using cryoprobes reported better yields than those without cryoprobes (90.0%, 95% CI: 83.2%–94.7% vs. 79.0%, 95% CI: 75.8%–82.2%, p < 0.01). The pooled complication rate was 3.0% (95% CI: 1.6%–4.4%). In conclusion, RAB is an effective and safe technique for PPLs diagnosis. Further high‐quality prospective studies still need to be conducted.https://doi.org/10.1111/1759-7714.15229bronchoscopylung cancermeta‐analysisperipheral pulmonary lesionrobotic‐assisted bronchoscopy |
| spellingShingle | Chunxi Zhang Fangfang Xie Runchang Li Ningxin Cui Felix J. F. Herth Jiayuan Sun Robotic‐assisted bronchoscopy for the diagnosis of peripheral pulmonary lesions: A systematic review and meta‐analysis Thoracic Cancer bronchoscopy lung cancer meta‐analysis peripheral pulmonary lesion robotic‐assisted bronchoscopy |
| title | Robotic‐assisted bronchoscopy for the diagnosis of peripheral pulmonary lesions: A systematic review and meta‐analysis |
| title_full | Robotic‐assisted bronchoscopy for the diagnosis of peripheral pulmonary lesions: A systematic review and meta‐analysis |
| title_fullStr | Robotic‐assisted bronchoscopy for the diagnosis of peripheral pulmonary lesions: A systematic review and meta‐analysis |
| title_full_unstemmed | Robotic‐assisted bronchoscopy for the diagnosis of peripheral pulmonary lesions: A systematic review and meta‐analysis |
| title_short | Robotic‐assisted bronchoscopy for the diagnosis of peripheral pulmonary lesions: A systematic review and meta‐analysis |
| title_sort | robotic assisted bronchoscopy for the diagnosis of peripheral pulmonary lesions a systematic review and meta analysis |
| topic | bronchoscopy lung cancer meta‐analysis peripheral pulmonary lesion robotic‐assisted bronchoscopy |
| url | https://doi.org/10.1111/1759-7714.15229 |
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