Retinal reperfusion in diabetic retinopathy following treatment with anti-VEGF intravitreal injections
Ariana M Levin, Irene Rusu, Anton Orlin, Mrinali P Gupta, Peter Coombs, Donald J D’Amico, Szilárd Kiss Department of Ophthalmology, Weill Cornell Medical College, New York, NY, USA Purpose: The aim of this study is to report peripheral reperfusion of ischemic areas of the reti...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2017-01-01
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| Series: | Clinical Ophthalmology |
| Subjects: | |
| Online Access: | https://www.dovepress.com/retinal--reperfusion-in-diabetic-retinopathy-following-treatment-with--peer-reviewed-article-OPTH |
| _version_ | 1818898007083450368 |
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| author | Levin AM Rusu I Orlin A Gupta MP Coombs P D'Amico DJ Kiss S |
| author_facet | Levin AM Rusu I Orlin A Gupta MP Coombs P D'Amico DJ Kiss S |
| author_sort | Levin AM |
| collection | DOAJ |
| description | Ariana M Levin, Irene Rusu, Anton Orlin, Mrinali P Gupta, Peter Coombs, Donald J D’Amico, Szilárd Kiss Department of Ophthalmology, Weill Cornell Medical College, New York, NY, USA Purpose: The aim of this study is to report peripheral reperfusion of ischemic areas of the retina on ultra-widefield fluorescein angiography (UWFA) following anti-vascular endothelial growth factor (VEGF) intravitreal injections in patients treated for diabetic retinopathy. Methods: This study is a retrospective review of 16 eyes of 15 patients with diabetic retinopathy, who received anti-VEGF intravitreal injections and underwent pre- and postinjection UWFA. The main outcome measured was the presence of reperfusion in postinjection UWFA images in areas of the retina that demonstrated nonperfusion in preinjection images. Images were analyzed for reperfusion qualitatively and quantitatively by two graders. Results: Twelve of 16 eyes (75%) or 11 of 15 patients (73.3%) demonstrated reperfusion following anti-VEGF injection. On UWFA, reperfusion was detected both within the field of 7-standard field (7SF) fluorescein angiography and in the periphery outside the 7SF. Four of 16 eyes or 4 of 15 patients did not demonstrate reperfusion, one of which had extensive scarring from prior panretinal photocoagulation. Conclusion: In patients with diabetic retinopathy, treatment with anti-VEGF agents can be associated with reperfusion of areas of nonperfusion, as demonstrated by UWFA. Keywords: anti-VEGF, diabetes, diabetic retinopathy, ischemia, perfusion, reperfusion |
| first_indexed | 2024-12-19T19:25:13Z |
| format | Article |
| id | doaj.art-9836855a8b7e430c965d41be6149fd53 |
| institution | Directory Open Access Journal |
| issn | 1177-5483 |
| language | English |
| last_indexed | 2024-12-19T19:25:13Z |
| publishDate | 2017-01-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Clinical Ophthalmology |
| spelling | doaj.art-9836855a8b7e430c965d41be6149fd532022-12-21T20:08:48ZengDove Medical PressClinical Ophthalmology1177-54832017-01-01Volume 1119320030945Retinal reperfusion in diabetic retinopathy following treatment with anti-VEGF intravitreal injectionsLevin AMRusu IOrlin AGupta MPCoombs PD'Amico DJKiss SAriana M Levin, Irene Rusu, Anton Orlin, Mrinali P Gupta, Peter Coombs, Donald J D’Amico, Szilárd Kiss Department of Ophthalmology, Weill Cornell Medical College, New York, NY, USA Purpose: The aim of this study is to report peripheral reperfusion of ischemic areas of the retina on ultra-widefield fluorescein angiography (UWFA) following anti-vascular endothelial growth factor (VEGF) intravitreal injections in patients treated for diabetic retinopathy. Methods: This study is a retrospective review of 16 eyes of 15 patients with diabetic retinopathy, who received anti-VEGF intravitreal injections and underwent pre- and postinjection UWFA. The main outcome measured was the presence of reperfusion in postinjection UWFA images in areas of the retina that demonstrated nonperfusion in preinjection images. Images were analyzed for reperfusion qualitatively and quantitatively by two graders. Results: Twelve of 16 eyes (75%) or 11 of 15 patients (73.3%) demonstrated reperfusion following anti-VEGF injection. On UWFA, reperfusion was detected both within the field of 7-standard field (7SF) fluorescein angiography and in the periphery outside the 7SF. Four of 16 eyes or 4 of 15 patients did not demonstrate reperfusion, one of which had extensive scarring from prior panretinal photocoagulation. Conclusion: In patients with diabetic retinopathy, treatment with anti-VEGF agents can be associated with reperfusion of areas of nonperfusion, as demonstrated by UWFA. Keywords: anti-VEGF, diabetes, diabetic retinopathy, ischemia, perfusion, reperfusionhttps://www.dovepress.com/retinal--reperfusion-in-diabetic-retinopathy-following-treatment-with--peer-reviewed-article-OPTHanti-VEGFdiabetesdiabetic retinopathyischemiaperfusionreperfusion |
| spellingShingle | Levin AM Rusu I Orlin A Gupta MP Coombs P D'Amico DJ Kiss S Retinal reperfusion in diabetic retinopathy following treatment with anti-VEGF intravitreal injections Clinical Ophthalmology anti-VEGF diabetes diabetic retinopathy ischemia perfusion reperfusion |
| title | Retinal reperfusion in diabetic retinopathy following treatment with anti-VEGF intravitreal injections |
| title_full | Retinal reperfusion in diabetic retinopathy following treatment with anti-VEGF intravitreal injections |
| title_fullStr | Retinal reperfusion in diabetic retinopathy following treatment with anti-VEGF intravitreal injections |
| title_full_unstemmed | Retinal reperfusion in diabetic retinopathy following treatment with anti-VEGF intravitreal injections |
| title_short | Retinal reperfusion in diabetic retinopathy following treatment with anti-VEGF intravitreal injections |
| title_sort | retinal reperfusion in diabetic retinopathy following treatment with anti vegf intravitreal injections |
| topic | anti-VEGF diabetes diabetic retinopathy ischemia perfusion reperfusion |
| url | https://www.dovepress.com/retinal--reperfusion-in-diabetic-retinopathy-following-treatment-with--peer-reviewed-article-OPTH |
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