Serum levels of bone sialoprotein correlate with portal pressure in patients with liver cirrhosis.
Liver cirrhosis represents the common end-stage of chronic liver diseases regardless of its etiology. Patients with compensated disease are mostly asymptomatic, however, progression to a decompensated disease stage is common. The available stratification strategies are often unsuitable to identify p...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2020-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0231701 |
| _version_ | 1818586482895486976 |
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| author | Fabian Benz Andreas Bogen Michael Praktiknjo Christian Jansen Carsten Meyer Alexander Wree Muenevver Demir Sven Loosen Mihael Vucur Robert Schierwagen Frank Tacke Jonel Trebicka Christoph Roderburg |
| author_facet | Fabian Benz Andreas Bogen Michael Praktiknjo Christian Jansen Carsten Meyer Alexander Wree Muenevver Demir Sven Loosen Mihael Vucur Robert Schierwagen Frank Tacke Jonel Trebicka Christoph Roderburg |
| author_sort | Fabian Benz |
| collection | DOAJ |
| description | Liver cirrhosis represents the common end-stage of chronic liver diseases regardless of its etiology. Patients with compensated disease are mostly asymptomatic, however, progression to a decompensated disease stage is common. The available stratification strategies are often unsuitable to identify patients with a higher risk for disease progression and a limited prognosis. SIBLINGs, soluble glycophosphoproteins, are secreted into the blood by immune-cells. While osteopontin, the most prominent member of the SIBLINGs family, has been repeatedly associated with liver cirrhosis, data on the diagnostic and/or prognostic value of bone sialoprotein (BSP) are scarce and partly inconclusive. In this study, we analyzed the diagnostic and prognostic potential of circulating BSP in comparison to other standard laboratory markers in a large cohort of patients with liver cirrhosis receiving transjugular intrahepatic portosystemic shunt (TIPS). Serum levels of BSP were similar in patients with different disease stages and were not indicative for prognosis. Interestingly, BSP serum levels did correlate inversely with portal pressure, as well as its surrogates such as platelet count, the portal vein cross-sectional area and correlated positively with the portal venous velocity. In summary, our data highlight that BSP might represent a previously unrecognized marker for portal hypertension in patients with liver cirrhosis. |
| first_indexed | 2024-12-16T08:53:40Z |
| format | Article |
| id | doaj.art-9836b6db948a46ed9dcb15b074781d39 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-16T08:53:40Z |
| publishDate | 2020-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-9836b6db948a46ed9dcb15b074781d392022-12-21T22:37:20ZengPublic Library of Science (PLoS)PLoS ONE1932-62032020-01-01154e023170110.1371/journal.pone.0231701Serum levels of bone sialoprotein correlate with portal pressure in patients with liver cirrhosis.Fabian BenzAndreas BogenMichael PraktiknjoChristian JansenCarsten MeyerAlexander WreeMuenevver DemirSven LoosenMihael VucurRobert SchierwagenFrank TackeJonel TrebickaChristoph RoderburgLiver cirrhosis represents the common end-stage of chronic liver diseases regardless of its etiology. Patients with compensated disease are mostly asymptomatic, however, progression to a decompensated disease stage is common. The available stratification strategies are often unsuitable to identify patients with a higher risk for disease progression and a limited prognosis. SIBLINGs, soluble glycophosphoproteins, are secreted into the blood by immune-cells. While osteopontin, the most prominent member of the SIBLINGs family, has been repeatedly associated with liver cirrhosis, data on the diagnostic and/or prognostic value of bone sialoprotein (BSP) are scarce and partly inconclusive. In this study, we analyzed the diagnostic and prognostic potential of circulating BSP in comparison to other standard laboratory markers in a large cohort of patients with liver cirrhosis receiving transjugular intrahepatic portosystemic shunt (TIPS). Serum levels of BSP were similar in patients with different disease stages and were not indicative for prognosis. Interestingly, BSP serum levels did correlate inversely with portal pressure, as well as its surrogates such as platelet count, the portal vein cross-sectional area and correlated positively with the portal venous velocity. In summary, our data highlight that BSP might represent a previously unrecognized marker for portal hypertension in patients with liver cirrhosis.https://doi.org/10.1371/journal.pone.0231701 |
| spellingShingle | Fabian Benz Andreas Bogen Michael Praktiknjo Christian Jansen Carsten Meyer Alexander Wree Muenevver Demir Sven Loosen Mihael Vucur Robert Schierwagen Frank Tacke Jonel Trebicka Christoph Roderburg Serum levels of bone sialoprotein correlate with portal pressure in patients with liver cirrhosis. PLoS ONE |
| title | Serum levels of bone sialoprotein correlate with portal pressure in patients with liver cirrhosis. |
| title_full | Serum levels of bone sialoprotein correlate with portal pressure in patients with liver cirrhosis. |
| title_fullStr | Serum levels of bone sialoprotein correlate with portal pressure in patients with liver cirrhosis. |
| title_full_unstemmed | Serum levels of bone sialoprotein correlate with portal pressure in patients with liver cirrhosis. |
| title_short | Serum levels of bone sialoprotein correlate with portal pressure in patients with liver cirrhosis. |
| title_sort | serum levels of bone sialoprotein correlate with portal pressure in patients with liver cirrhosis |
| url | https://doi.org/10.1371/journal.pone.0231701 |
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