Abnormal functional asymmetry and its behavioural correlates in adults with ADHD: A TMS-EEG study.
<h4>Objectives</h4>Abnormal functional brain asymmetry and deficient response inhibition are two core symptoms of attention deficit hyperactivity disorder (ADHD). We investigated whether these symptoms are inter-related and whether they are underlined by altered frontal excitability and...
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Format: | Article |
Language: | English |
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Public Library of Science (PLoS)
2023-01-01
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Series: | PLoS ONE |
Online Access: | https://doi.org/10.1371/journal.pone.0285086 |
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author | Amir Avnit Samuel Zibman Uri Alyagon Abraham Zangen |
author_facet | Amir Avnit Samuel Zibman Uri Alyagon Abraham Zangen |
author_sort | Amir Avnit |
collection | DOAJ |
description | <h4>Objectives</h4>Abnormal functional brain asymmetry and deficient response inhibition are two core symptoms of attention deficit hyperactivity disorder (ADHD). We investigated whether these symptoms are inter-related and whether they are underlined by altered frontal excitability and by compromised interhemispheric connectivity.<h4>Methods</h4>We studied these issues in 52 ADHD and 43 non-clinical adults by comparing: (1) stop-signal reaction time (SSRT); (2) frontal asymmetry of the N200 event-related potential component, which is evoked during response inhibition and is lateralised to the right hemisphere; (3) TMS-evoked potential (TEP) in the right frontal hemisphere, which is indicative of local cortical excitability; and (4) frontal right-to-left interhemispheric TMS signal propagation (ISP), which is reversely indicative of interhemispheric connectivity.<h4>Results</h4>Compared to controls, the ADHD group demonstrated elongated SSRT, reduced N200 right-frontal-asymmetry, weaker TEP, and stronger ISP. Moreover, in the ADHD group, N200 right-frontal-asymmetry correlated with SSRT, with TEP, and with symptoms severity. Conversely, no relationship was observed between ISP and N200 right-frontal-asymmetry, and both TEP and ISP were found to be unrelated to SSRT.<h4>Conclusions</h4>Our results indicate that abnormal frontal asymmetry is related to a key cognitive symptom in ADHD and suggest that it is underlined by reduced right-frontal excitability. |
first_indexed | 2024-03-13T05:56:08Z |
format | Article |
id | doaj.art-9836bd1a1dbf446db8b9720f56ed9a2a |
institution | Directory Open Access Journal |
issn | 1932-6203 |
language | English |
last_indexed | 2024-03-13T05:56:08Z |
publishDate | 2023-01-01 |
publisher | Public Library of Science (PLoS) |
record_format | Article |
series | PLoS ONE |
spelling | doaj.art-9836bd1a1dbf446db8b9720f56ed9a2a2023-06-13T05:31:27ZengPublic Library of Science (PLoS)PLoS ONE1932-62032023-01-01185e028508610.1371/journal.pone.0285086Abnormal functional asymmetry and its behavioural correlates in adults with ADHD: A TMS-EEG study.Amir AvnitSamuel ZibmanUri AlyagonAbraham Zangen<h4>Objectives</h4>Abnormal functional brain asymmetry and deficient response inhibition are two core symptoms of attention deficit hyperactivity disorder (ADHD). We investigated whether these symptoms are inter-related and whether they are underlined by altered frontal excitability and by compromised interhemispheric connectivity.<h4>Methods</h4>We studied these issues in 52 ADHD and 43 non-clinical adults by comparing: (1) stop-signal reaction time (SSRT); (2) frontal asymmetry of the N200 event-related potential component, which is evoked during response inhibition and is lateralised to the right hemisphere; (3) TMS-evoked potential (TEP) in the right frontal hemisphere, which is indicative of local cortical excitability; and (4) frontal right-to-left interhemispheric TMS signal propagation (ISP), which is reversely indicative of interhemispheric connectivity.<h4>Results</h4>Compared to controls, the ADHD group demonstrated elongated SSRT, reduced N200 right-frontal-asymmetry, weaker TEP, and stronger ISP. Moreover, in the ADHD group, N200 right-frontal-asymmetry correlated with SSRT, with TEP, and with symptoms severity. Conversely, no relationship was observed between ISP and N200 right-frontal-asymmetry, and both TEP and ISP were found to be unrelated to SSRT.<h4>Conclusions</h4>Our results indicate that abnormal frontal asymmetry is related to a key cognitive symptom in ADHD and suggest that it is underlined by reduced right-frontal excitability.https://doi.org/10.1371/journal.pone.0285086 |
spellingShingle | Amir Avnit Samuel Zibman Uri Alyagon Abraham Zangen Abnormal functional asymmetry and its behavioural correlates in adults with ADHD: A TMS-EEG study. PLoS ONE |
title | Abnormal functional asymmetry and its behavioural correlates in adults with ADHD: A TMS-EEG study. |
title_full | Abnormal functional asymmetry and its behavioural correlates in adults with ADHD: A TMS-EEG study. |
title_fullStr | Abnormal functional asymmetry and its behavioural correlates in adults with ADHD: A TMS-EEG study. |
title_full_unstemmed | Abnormal functional asymmetry and its behavioural correlates in adults with ADHD: A TMS-EEG study. |
title_short | Abnormal functional asymmetry and its behavioural correlates in adults with ADHD: A TMS-EEG study. |
title_sort | abnormal functional asymmetry and its behavioural correlates in adults with adhd a tms eeg study |
url | https://doi.org/10.1371/journal.pone.0285086 |
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