Complete Response of Triple-Negative Metaplastic Carcinoma of the Breast Using Pembrolizumab
Metaplastic breast cancer (MpBC) is a rare form of breast malignancy with a poor prognosis and limited treatment guidance. Here, we report on a case of triple-negative MpBC that was successfully treated following the Keynote-522 clinical algorithm using pembrolizumab, paclitaxel, carboplatin, adriam...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Karger Publishers
2023-10-01
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| Series: | Case Reports in Oncology |
| Subjects: | |
| Online Access: | https://beta.karger.com/Article/FullText/534146 |
| _version_ | 1827761648934322176 |
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| author | Amrita Ladwa Omar Elghawy Anneke Schroen Kristan Abernathy Jenna Schlefman Patrick Dillon |
| author_facet | Amrita Ladwa Omar Elghawy Anneke Schroen Kristan Abernathy Jenna Schlefman Patrick Dillon |
| author_sort | Amrita Ladwa |
| collection | DOAJ |
| description | Metaplastic breast cancer (MpBC) is a rare form of breast malignancy with a poor prognosis and limited treatment guidance. Here, we report on a case of triple-negative MpBC that was successfully treated following the Keynote-522 clinical algorithm using pembrolizumab, paclitaxel, carboplatin, adriamycin, and cyclophosphamide in a neo-adjuvant fashion. The radiographic and histologic findings of the tumor are reviewed here along with the treatment regimen and response. No major toxicities associated with pembrolizumab were observed in this case. This case report serves as an example of complete pathological response of triple-negative MpBC with pembrolizumab plus chemotherapy and demonstrates the need for further research on chemoimmunotherapy for MpBC. |
| first_indexed | 2024-03-11T10:15:56Z |
| format | Article |
| id | doaj.art-9836f39374b74ab0b834f4800f251e9e |
| institution | Directory Open Access Journal |
| issn | 1662-6575 |
| language | English |
| last_indexed | 2024-03-11T10:15:56Z |
| publishDate | 2023-10-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Oncology |
| spelling | doaj.art-9836f39374b74ab0b834f4800f251e9e2023-11-16T07:58:20ZengKarger PublishersCase Reports in Oncology1662-65752023-10-011611129113510.1159/000534146534146Complete Response of Triple-Negative Metaplastic Carcinoma of the Breast Using PembrolizumabAmrita Ladwa0Omar Elghawy1Anneke Schroen2Kristan Abernathy3Jenna Schlefman4Patrick Dillon5Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA, USADepartment of General Internal Medicine, University of Pennsylvania, Philadelphia, PA, USADepartment of Medicine, University of Virginia Cancer Center, Charlottesville, VA, USADepartment of Pathology, University of Virginia, Charlottesville, VA, USADepartment of Medicine, University of Virginia Cancer Center, Charlottesville, VA, USADepartment of Medicine, University of Virginia Cancer Center, Charlottesville, VA, USAMetaplastic breast cancer (MpBC) is a rare form of breast malignancy with a poor prognosis and limited treatment guidance. Here, we report on a case of triple-negative MpBC that was successfully treated following the Keynote-522 clinical algorithm using pembrolizumab, paclitaxel, carboplatin, adriamycin, and cyclophosphamide in a neo-adjuvant fashion. The radiographic and histologic findings of the tumor are reviewed here along with the treatment regimen and response. No major toxicities associated with pembrolizumab were observed in this case. This case report serves as an example of complete pathological response of triple-negative MpBC with pembrolizumab plus chemotherapy and demonstrates the need for further research on chemoimmunotherapy for MpBC.https://beta.karger.com/Article/FullText/534146metaplastic breast cancerimmunotherapytriple-negative metaplastic breast cancerpembrolizumabcase report |
| spellingShingle | Amrita Ladwa Omar Elghawy Anneke Schroen Kristan Abernathy Jenna Schlefman Patrick Dillon Complete Response of Triple-Negative Metaplastic Carcinoma of the Breast Using Pembrolizumab Case Reports in Oncology metaplastic breast cancer immunotherapy triple-negative metaplastic breast cancer pembrolizumab case report |
| title | Complete Response of Triple-Negative Metaplastic Carcinoma of the Breast Using Pembrolizumab |
| title_full | Complete Response of Triple-Negative Metaplastic Carcinoma of the Breast Using Pembrolizumab |
| title_fullStr | Complete Response of Triple-Negative Metaplastic Carcinoma of the Breast Using Pembrolizumab |
| title_full_unstemmed | Complete Response of Triple-Negative Metaplastic Carcinoma of the Breast Using Pembrolizumab |
| title_short | Complete Response of Triple-Negative Metaplastic Carcinoma of the Breast Using Pembrolizumab |
| title_sort | complete response of triple negative metaplastic carcinoma of the breast using pembrolizumab |
| topic | metaplastic breast cancer immunotherapy triple-negative metaplastic breast cancer pembrolizumab case report |
| url | https://beta.karger.com/Article/FullText/534146 |
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