Efficacy and Safety of Chinese Patent Medicine Combined With Oseltamivir in Treatment of Children With Influenza: A meta-Analysis
Background: Recently, Chinese patent medicines (CPMs) have been widely used to treat children with influenza in China, with curative effects. Therefore, the efficacy and safety of such treatment require further evaluation. The present meta-analysis integrated data from several independent studies to...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2021-08-01
|
| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2021.682732/full |
| _version_ | 1819130442783129600 |
|---|---|
| author | Nai-fan Duan Nai-fan Duan Bin Liu Xiao-na Li Xiao-na Li Yi-bai Xiong Yi-bai Xiong Yan Zhang Yan Zhang Chi Zhang Li LI Li LI Cheng Lu Cheng Lu Jueni Lyu |
| author_facet | Nai-fan Duan Nai-fan Duan Bin Liu Xiao-na Li Xiao-na Li Yi-bai Xiong Yi-bai Xiong Yan Zhang Yan Zhang Chi Zhang Li LI Li LI Cheng Lu Cheng Lu Jueni Lyu |
| author_sort | Nai-fan Duan |
| collection | DOAJ |
| description | Background: Recently, Chinese patent medicines (CPMs) have been widely used to treat children with influenza in China, with curative effects. Therefore, the efficacy and safety of such treatment require further evaluation. The present meta-analysis integrated data from several independent studies to determine overall treatment trends in children with influenza.Methods: The following databases were searched for randomized controlled trials (RCTs) published from their inception to December 12, 2020: CNKI, Wanfang, SinoMed, PubMed, Cochrane library, and Embase. Two researchers independently extracted the data, assessed the methodological quality of the studies, and conducted a meta-analysis of the results using Review Manager 5.2. The results were assessed using forest plots, and publication bias was evaluated using a funnel plot.Results: A total of 21 RCTs involving 2960 cases were included. Compared to oseltamivir alone, CPMs combined with oseltamivir reduced the duration of symptoms, including that of fever (mean difference [MD] = −0.64, 95% confidence interval [CI]: −0.86 to −0.41, P < 0.00001), cough (MD = −0.82, 95% CI: −1.02 to −0.62, P < 0.00001), nasal obstruction (MD = −0.88, 95% CI: −1.15 to −0.61, P < 0.00001), and sore throat (MD = −0.92, 95% CI: −1.26 to −0.57, P < 0.00001). Combined therapy also reduced the time of viral shedding (MD = −0.53, 95% CI: −0.70 to −0.36, P < 0.00001) and the occurrence of adverse drug reactions (ADRs) (RR=0.53, 95% CI: 0.34 to 0.83, P = 0.005).Conclusions: CPMs combined with oseltamivir reduced the duration of symptoms, shortened the time of viral shedding, and reduced the number of ADRs. However, these results should be considered with caution because there was marked heterogeneity and publication bias in the research data. More rigorous RCTs should be designed to verify the effect of CPMs in children with influenza. |
| first_indexed | 2024-12-22T08:59:41Z |
| format | Article |
| id | doaj.art-9838ce4f3a5441a89f2f3a0946814b2b |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-22T08:59:41Z |
| publishDate | 2021-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-9838ce4f3a5441a89f2f3a0946814b2b2022-12-21T18:31:45ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122021-08-011210.3389/fphar.2021.682732682732Efficacy and Safety of Chinese Patent Medicine Combined With Oseltamivir in Treatment of Children With Influenza: A meta-AnalysisNai-fan Duan0Nai-fan Duan1Bin Liu2Xiao-na Li3Xiao-na Li4Yi-bai Xiong5Yi-bai Xiong6Yan Zhang7Yan Zhang8Chi Zhang9Li LI10Li LI11Cheng Lu12Cheng Lu13Jueni Lyu14Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Science, Beijing, ChinaChina Center for Evidence Based Traditional Chinese Medicine, Beijing, ChinaInstitute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Science, Beijing, ChinaInstitute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Science, Beijing, ChinaChina Center for Evidence Based Traditional Chinese Medicine, Beijing, ChinaInstitute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Science, Beijing, ChinaChina Center for Evidence Based Traditional Chinese Medicine, Beijing, ChinaInstitute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Science, Beijing, ChinaChina Center for Evidence Based Traditional Chinese Medicine, Beijing, ChinaDongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, ChinaInstitute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Science, Beijing, ChinaChina Center for Evidence Based Traditional Chinese Medicine, Beijing, ChinaInstitute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Science, Beijing, ChinaChina Center for Evidence Based Traditional Chinese Medicine, Beijing, ChinaHKU Business School, The University of Hong Kong, Pok Fu Lam, Hong KongBackground: Recently, Chinese patent medicines (CPMs) have been widely used to treat children with influenza in China, with curative effects. Therefore, the efficacy and safety of such treatment require further evaluation. The present meta-analysis integrated data from several independent studies to determine overall treatment trends in children with influenza.Methods: The following databases were searched for randomized controlled trials (RCTs) published from their inception to December 12, 2020: CNKI, Wanfang, SinoMed, PubMed, Cochrane library, and Embase. Two researchers independently extracted the data, assessed the methodological quality of the studies, and conducted a meta-analysis of the results using Review Manager 5.2. The results were assessed using forest plots, and publication bias was evaluated using a funnel plot.Results: A total of 21 RCTs involving 2960 cases were included. Compared to oseltamivir alone, CPMs combined with oseltamivir reduced the duration of symptoms, including that of fever (mean difference [MD] = −0.64, 95% confidence interval [CI]: −0.86 to −0.41, P < 0.00001), cough (MD = −0.82, 95% CI: −1.02 to −0.62, P < 0.00001), nasal obstruction (MD = −0.88, 95% CI: −1.15 to −0.61, P < 0.00001), and sore throat (MD = −0.92, 95% CI: −1.26 to −0.57, P < 0.00001). Combined therapy also reduced the time of viral shedding (MD = −0.53, 95% CI: −0.70 to −0.36, P < 0.00001) and the occurrence of adverse drug reactions (ADRs) (RR=0.53, 95% CI: 0.34 to 0.83, P = 0.005).Conclusions: CPMs combined with oseltamivir reduced the duration of symptoms, shortened the time of viral shedding, and reduced the number of ADRs. However, these results should be considered with caution because there was marked heterogeneity and publication bias in the research data. More rigorous RCTs should be designed to verify the effect of CPMs in children with influenza.https://www.frontiersin.org/articles/10.3389/fphar.2021.682732/fullinfluenzachildrenChinese patent medicineoseltamivirmeta-analysis |
| spellingShingle | Nai-fan Duan Nai-fan Duan Bin Liu Xiao-na Li Xiao-na Li Yi-bai Xiong Yi-bai Xiong Yan Zhang Yan Zhang Chi Zhang Li LI Li LI Cheng Lu Cheng Lu Jueni Lyu Efficacy and Safety of Chinese Patent Medicine Combined With Oseltamivir in Treatment of Children With Influenza: A meta-Analysis Frontiers in Pharmacology influenza children Chinese patent medicine oseltamivir meta-analysis |
| title | Efficacy and Safety of Chinese Patent Medicine Combined With Oseltamivir in Treatment of Children With Influenza: A meta-Analysis |
| title_full | Efficacy and Safety of Chinese Patent Medicine Combined With Oseltamivir in Treatment of Children With Influenza: A meta-Analysis |
| title_fullStr | Efficacy and Safety of Chinese Patent Medicine Combined With Oseltamivir in Treatment of Children With Influenza: A meta-Analysis |
| title_full_unstemmed | Efficacy and Safety of Chinese Patent Medicine Combined With Oseltamivir in Treatment of Children With Influenza: A meta-Analysis |
| title_short | Efficacy and Safety of Chinese Patent Medicine Combined With Oseltamivir in Treatment of Children With Influenza: A meta-Analysis |
| title_sort | efficacy and safety of chinese patent medicine combined with oseltamivir in treatment of children with influenza a meta analysis |
| topic | influenza children Chinese patent medicine oseltamivir meta-analysis |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2021.682732/full |
| work_keys_str_mv | AT naifanduan efficacyandsafetyofchinesepatentmedicinecombinedwithoseltamivirintreatmentofchildrenwithinfluenzaametaanalysis AT naifanduan efficacyandsafetyofchinesepatentmedicinecombinedwithoseltamivirintreatmentofchildrenwithinfluenzaametaanalysis AT binliu efficacyandsafetyofchinesepatentmedicinecombinedwithoseltamivirintreatmentofchildrenwithinfluenzaametaanalysis AT xiaonali efficacyandsafetyofchinesepatentmedicinecombinedwithoseltamivirintreatmentofchildrenwithinfluenzaametaanalysis AT xiaonali efficacyandsafetyofchinesepatentmedicinecombinedwithoseltamivirintreatmentofchildrenwithinfluenzaametaanalysis AT yibaixiong efficacyandsafetyofchinesepatentmedicinecombinedwithoseltamivirintreatmentofchildrenwithinfluenzaametaanalysis AT yibaixiong efficacyandsafetyofchinesepatentmedicinecombinedwithoseltamivirintreatmentofchildrenwithinfluenzaametaanalysis AT yanzhang efficacyandsafetyofchinesepatentmedicinecombinedwithoseltamivirintreatmentofchildrenwithinfluenzaametaanalysis AT yanzhang efficacyandsafetyofchinesepatentmedicinecombinedwithoseltamivirintreatmentofchildrenwithinfluenzaametaanalysis AT chizhang efficacyandsafetyofchinesepatentmedicinecombinedwithoseltamivirintreatmentofchildrenwithinfluenzaametaanalysis AT lili efficacyandsafetyofchinesepatentmedicinecombinedwithoseltamivirintreatmentofchildrenwithinfluenzaametaanalysis AT lili efficacyandsafetyofchinesepatentmedicinecombinedwithoseltamivirintreatmentofchildrenwithinfluenzaametaanalysis AT chenglu efficacyandsafetyofchinesepatentmedicinecombinedwithoseltamivirintreatmentofchildrenwithinfluenzaametaanalysis AT chenglu efficacyandsafetyofchinesepatentmedicinecombinedwithoseltamivirintreatmentofchildrenwithinfluenzaametaanalysis AT juenilyu efficacyandsafetyofchinesepatentmedicinecombinedwithoseltamivirintreatmentofchildrenwithinfluenzaametaanalysis |