Impact of solute carrier transporter gene polymorphisms on serum creatinine concentrations in healthy volunteers
Abstract In this study, we investigated the impact of single nucleotide polymorphisms in solute carrier (SLC) transporters, that is, SLC22A7 c.1586 + 206A > G, SLC22A2 c.808G > T, SLC22A3 c.1233G > A, SLC47A1 c.922‐158G > A, and SLC47A2 c.‐130G > A, on serum creatinine (SCr) concentra...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-02-01
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| Series: | Pharmacology Research & Perspectives |
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| Online Access: | https://doi.org/10.1002/prp2.1048 |
| _version_ | 1811165280200556544 |
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| author | Satoshi Yokoyama Junichi Nakagawa Masakiyo Kudo Naoya Aiuchi Tatsuya Seito Mizuri Isida Tatsuya Mikami Kazushige Ihara Shigeyuki Nakaji Takenori Niioka |
| author_facet | Satoshi Yokoyama Junichi Nakagawa Masakiyo Kudo Naoya Aiuchi Tatsuya Seito Mizuri Isida Tatsuya Mikami Kazushige Ihara Shigeyuki Nakaji Takenori Niioka |
| author_sort | Satoshi Yokoyama |
| collection | DOAJ |
| description | Abstract In this study, we investigated the impact of single nucleotide polymorphisms in solute carrier (SLC) transporters, that is, SLC22A7 c.1586 + 206A > G, SLC22A2 c.808G > T, SLC22A3 c.1233G > A, SLC47A1 c.922‐158G > A, and SLC47A2 c.‐130G > A, on serum creatinine (SCr) concentrations. This cross‐sectional study included residents who participated as volunteers in a health promotion study. Lifestyle data, blood chemical analysis data, and SLC gene polymorphism information were collected from each participant. Univariate analyses were carried out to determine differences between groups and correlations in SCr. Stepwise multiple regression analysis was performed to confirm the independence of factors that were significantly different in the univariate analyses. In multiple regression analyses, muscle mass, serum cystatin C concentrations, body fat percentage, serum albumin concentrations, and SLC47A2 c.‐130G/G had the highest contribution to SCr concentrations, in that order (standardized regression coefficients = .505, .332, −.234, .123, and .084, respectively). The final model explained 72.2% of the variability in SCr concentrations. The SLC47A2 c.‐130G > A polymorphism may affect creatinine dynamics in the proximal tubules. Further studies are needed to determine the effects of SLC transporter gene polymorphisms on SCr concentrations in patients with various diseases in real‐world clinical settings. |
| first_indexed | 2024-04-10T15:34:41Z |
| format | Article |
| id | doaj.art-983c738879de430092b8eb37e17e13d5 |
| institution | Directory Open Access Journal |
| issn | 2052-1707 |
| language | English |
| last_indexed | 2024-04-10T15:34:41Z |
| publishDate | 2023-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | Pharmacology Research & Perspectives |
| spelling | doaj.art-983c738879de430092b8eb37e17e13d52023-02-13T07:58:31ZengWileyPharmacology Research & Perspectives2052-17072023-02-01111n/an/a10.1002/prp2.1048Impact of solute carrier transporter gene polymorphisms on serum creatinine concentrations in healthy volunteersSatoshi Yokoyama0Junichi Nakagawa1Masakiyo Kudo2Naoya Aiuchi3Tatsuya Seito4Mizuri Isida5Tatsuya Mikami6Kazushige Ihara7Shigeyuki Nakaji8Takenori Niioka9Department of Pharmaceutical Science Hirosaki University Graduate School of Medicine Hirosaki Aomori JapanDepartment of Pharmacy Hirosaki University Hospital Hirosaki Aomori JapanDepartment of Pharmacy Hirosaki University Hospital Hirosaki Aomori JapanDepartment of Pharmacy Hirosaki University Hospital Hirosaki Aomori JapanDepartment of Pharmacy Hirosaki Central Hospital Hirosaki Aomori JapanDepartment of Innovation Center for Health Promotion Hirosaki University Graduate School of Medicine Hirosaki Aomori JapanDepartment of Innovation Center for Health Promotion Hirosaki University Graduate School of Medicine Hirosaki Aomori JapanDepartment of Social Medicine Hirosaki University Graduate School of Medicine Hirosaki Aomori JapanDepartment of Social Medicine Hirosaki University Graduate School of Medicine Hirosaki Aomori JapanDepartment of Pharmaceutical Science Hirosaki University Graduate School of Medicine Hirosaki Aomori JapanAbstract In this study, we investigated the impact of single nucleotide polymorphisms in solute carrier (SLC) transporters, that is, SLC22A7 c.1586 + 206A > G, SLC22A2 c.808G > T, SLC22A3 c.1233G > A, SLC47A1 c.922‐158G > A, and SLC47A2 c.‐130G > A, on serum creatinine (SCr) concentrations. This cross‐sectional study included residents who participated as volunteers in a health promotion study. Lifestyle data, blood chemical analysis data, and SLC gene polymorphism information were collected from each participant. Univariate analyses were carried out to determine differences between groups and correlations in SCr. Stepwise multiple regression analysis was performed to confirm the independence of factors that were significantly different in the univariate analyses. In multiple regression analyses, muscle mass, serum cystatin C concentrations, body fat percentage, serum albumin concentrations, and SLC47A2 c.‐130G/G had the highest contribution to SCr concentrations, in that order (standardized regression coefficients = .505, .332, −.234, .123, and .084, respectively). The final model explained 72.2% of the variability in SCr concentrations. The SLC47A2 c.‐130G > A polymorphism may affect creatinine dynamics in the proximal tubules. Further studies are needed to determine the effects of SLC transporter gene polymorphisms on SCr concentrations in patients with various diseases in real‐world clinical settings.https://doi.org/10.1002/prp2.1048muscle massserum creatininesolute carrier transportertubular secretionSLC47A2 polymorphism |
| spellingShingle | Satoshi Yokoyama Junichi Nakagawa Masakiyo Kudo Naoya Aiuchi Tatsuya Seito Mizuri Isida Tatsuya Mikami Kazushige Ihara Shigeyuki Nakaji Takenori Niioka Impact of solute carrier transporter gene polymorphisms on serum creatinine concentrations in healthy volunteers Pharmacology Research & Perspectives muscle mass serum creatinine solute carrier transporter tubular secretion SLC47A2 polymorphism |
| title | Impact of solute carrier transporter gene polymorphisms on serum creatinine concentrations in healthy volunteers |
| title_full | Impact of solute carrier transporter gene polymorphisms on serum creatinine concentrations in healthy volunteers |
| title_fullStr | Impact of solute carrier transporter gene polymorphisms on serum creatinine concentrations in healthy volunteers |
| title_full_unstemmed | Impact of solute carrier transporter gene polymorphisms on serum creatinine concentrations in healthy volunteers |
| title_short | Impact of solute carrier transporter gene polymorphisms on serum creatinine concentrations in healthy volunteers |
| title_sort | impact of solute carrier transporter gene polymorphisms on serum creatinine concentrations in healthy volunteers |
| topic | muscle mass serum creatinine solute carrier transporter tubular secretion SLC47A2 polymorphism |
| url | https://doi.org/10.1002/prp2.1048 |
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