Optimization of High-Pressure Ultrasonic-Assisted Simultaneous Extraction of Six Major Constituents from Ligusticum chuanxiong Rhizome using Response Surface Methodology
High-pressure ultrasound-assisted extraction technology was applied to extract ferulic acid, senkyunolide I, senkyunolide H, senkyunolide A, ligustilide and levistolide A from Ligusticum chuanxiong rhizomes. Seven independent variables, including solvent type, pressure, particle size, liquid-to-soli...
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| Format: | Article |
| Language: | English |
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MDPI AG
2014-02-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/19/2/1887 |
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| author | Jin-Liang Liu Shun-Lin Zheng Qiao-Jia Fan Ji-Chao Yuan Shi-Min Yang Fan-Lei Kong |
| author_facet | Jin-Liang Liu Shun-Lin Zheng Qiao-Jia Fan Ji-Chao Yuan Shi-Min Yang Fan-Lei Kong |
| author_sort | Jin-Liang Liu |
| collection | DOAJ |
| description | High-pressure ultrasound-assisted extraction technology was applied to extract ferulic acid, senkyunolide I, senkyunolide H, senkyunolide A, ligustilide and levistolide A from Ligusticum chuanxiong rhizomes. Seven independent variables, including solvent type, pressure, particle size, liquid-to-solid ratio, extraction temperature, ultrasound power, and extraction time were examined. Response Surface Methodology (RSM) using a Central Composite Design (CCD) was employed to optimize the experimental conditions (extraction temperature, ultrasonic power, and extraction time) on the basis of the results of single factor tests for the extraction of these six major components in L. chuanxiong rhizomes. The experimental data were fitted to a second-order polynomial equation using multiple regression analysis and were also examined using appropriate statistical methods. The best extraction conditions were as follows: extraction solvent: 40% ethanol; pressure: 10 MPa; particle size: 80 mesh; liquid-to-solid ratio: 100:1; extraction temperature: 70 °C; ultrasonic power, 180 W; and extraction time, 74 min. |
| first_indexed | 2024-04-13T20:52:54Z |
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| id | doaj.art-983d53721dba4513bdf23c958c558ef6 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-04-13T20:52:54Z |
| publishDate | 2014-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-983d53721dba4513bdf23c958c558ef62022-12-22T02:30:27ZengMDPI AGMolecules1420-30492014-02-011921887191110.3390/molecules19021887molecules19021887Optimization of High-Pressure Ultrasonic-Assisted Simultaneous Extraction of Six Major Constituents from Ligusticum chuanxiong Rhizome using Response Surface MethodologyJin-Liang Liu0Shun-Lin Zheng1Qiao-Jia Fan2Ji-Chao Yuan3Shi-Min Yang4Fan-Lei Kong5College of Agronomy, Sichuan Agricultural University, Chengdu 611130, ChinaCollege of Agronomy, Sichuan Agricultural University, Chengdu 611130, ChinaCollege of Veterinary Medicine, Sichuan Agricultural University, Ya'an 625014, ChinaCollege of Agronomy, Sichuan Agricultural University, Chengdu 611130, ChinaCollege of Agronomy, Sichuan Agricultural University, Chengdu 611130, ChinaCollege of Agronomy, Sichuan Agricultural University, Chengdu 611130, ChinaHigh-pressure ultrasound-assisted extraction technology was applied to extract ferulic acid, senkyunolide I, senkyunolide H, senkyunolide A, ligustilide and levistolide A from Ligusticum chuanxiong rhizomes. Seven independent variables, including solvent type, pressure, particle size, liquid-to-solid ratio, extraction temperature, ultrasound power, and extraction time were examined. Response Surface Methodology (RSM) using a Central Composite Design (CCD) was employed to optimize the experimental conditions (extraction temperature, ultrasonic power, and extraction time) on the basis of the results of single factor tests for the extraction of these six major components in L. chuanxiong rhizomes. The experimental data were fitted to a second-order polynomial equation using multiple regression analysis and were also examined using appropriate statistical methods. The best extraction conditions were as follows: extraction solvent: 40% ethanol; pressure: 10 MPa; particle size: 80 mesh; liquid-to-solid ratio: 100:1; extraction temperature: 70 °C; ultrasonic power, 180 W; and extraction time, 74 min.http://www.mdpi.com/1420-3049/19/2/1887Ligusticum chuanxiongmajor constituentsresponse surface methodologyoptimizationhigh-pressure ultrasonic-assisted extraction |
| spellingShingle | Jin-Liang Liu Shun-Lin Zheng Qiao-Jia Fan Ji-Chao Yuan Shi-Min Yang Fan-Lei Kong Optimization of High-Pressure Ultrasonic-Assisted Simultaneous Extraction of Six Major Constituents from Ligusticum chuanxiong Rhizome using Response Surface Methodology Molecules Ligusticum chuanxiong major constituents response surface methodology optimization high-pressure ultrasonic-assisted extraction |
| title | Optimization of High-Pressure Ultrasonic-Assisted Simultaneous Extraction of Six Major Constituents from Ligusticum chuanxiong Rhizome using Response Surface Methodology |
| title_full | Optimization of High-Pressure Ultrasonic-Assisted Simultaneous Extraction of Six Major Constituents from Ligusticum chuanxiong Rhizome using Response Surface Methodology |
| title_fullStr | Optimization of High-Pressure Ultrasonic-Assisted Simultaneous Extraction of Six Major Constituents from Ligusticum chuanxiong Rhizome using Response Surface Methodology |
| title_full_unstemmed | Optimization of High-Pressure Ultrasonic-Assisted Simultaneous Extraction of Six Major Constituents from Ligusticum chuanxiong Rhizome using Response Surface Methodology |
| title_short | Optimization of High-Pressure Ultrasonic-Assisted Simultaneous Extraction of Six Major Constituents from Ligusticum chuanxiong Rhizome using Response Surface Methodology |
| title_sort | optimization of high pressure ultrasonic assisted simultaneous extraction of six major constituents from ligusticum chuanxiong rhizome using response surface methodology |
| topic | Ligusticum chuanxiong major constituents response surface methodology optimization high-pressure ultrasonic-assisted extraction |
| url | http://www.mdpi.com/1420-3049/19/2/1887 |
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