Role of Polyanions and Surfactant Head Group in the Formation of Polymer–Colloid Nanocontainers
Objectives. This study was aimed at the investigation of the supramolecular systems based on cationic surfactants bearing cyclic head groups (imidazolium and pyrrolidinium) and polyanions (polyacrylic acid (PAA) and human serum albumin (HSA)), and factors governing their structural behavior to creat...
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| Format: | Article |
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MDPI AG
2023-03-01
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| Series: | Nanomaterials |
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| Online Access: | https://www.mdpi.com/2079-4991/13/6/1072 |
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| author | Elmira A. Vasilieva Darya A. Kuznetsova Farida G. Valeeva Denis M. Kuznetsov Lucia Ya. Zakharova |
| author_facet | Elmira A. Vasilieva Darya A. Kuznetsova Farida G. Valeeva Denis M. Kuznetsov Lucia Ya. Zakharova |
| author_sort | Elmira A. Vasilieva |
| collection | DOAJ |
| description | Objectives. This study was aimed at the investigation of the supramolecular systems based on cationic surfactants bearing cyclic head groups (imidazolium and pyrrolidinium) and polyanions (polyacrylic acid (PAA) and human serum albumin (HSA)), and factors governing their structural behavior to create functional nanosystems with controlled properties. Research hypothesis. Mixed PE–surfactant complexes based on oppositely charged species are characterized by multifactor behavior strongly affected by the nature of both components. It was expected that the transition from a single surfactant solution to an admixture with PE might provide synergetic effects on structural characteristics and functional activity. To test this assumption, the concentration thresholds of aggregation, dimensional and charge characteristics, and solubilization capacity of amphiphiles in the presence of PEs have been determined by tensiometry, fluorescence and UV-visible spectroscopy, and dynamic and electrophoretic light scattering. Results. The formation of mixed surfactant–PAA aggregates with a hydrodynamic diameter of 100–180 nm has been shown. Polyanion additives led to a decrease in the critical micelle concentration of surfactants by two orders of magnitude (from 1 mM to 0.01 mM). A gradual increase in the zeta potential of HAS–surfactant systems from negative to positive value indicates that the electrostatic mechanism contributes to the binding of components. Additionally, 3D and conventional fluorescence spectroscopy showed that imidazolium surfactant had little effect on HSA conformation, and component binding occurs due to hydrogen bonding and Van der Waals interactions through the tryptophan amino acid residue of the protein. Surfactant–polyanion nanostructures improve the solubility of lipophilic medicines such as Warfarin, Amphotericin B, and Meloxicam. Perspectives. Surfactant–PE composition demonstrated beneficial solubilization activity and can be recommended for the construction of nanocontainers for hydrophobic drugs, with their efficacy tuned by the variation in surfactant head group and the nature of polyanions. |
| first_indexed | 2024-03-11T06:05:18Z |
| format | Article |
| id | doaj.art-983dcae6b79b447c999f7d127b7c82be |
| institution | Directory Open Access Journal |
| issn | 2079-4991 |
| language | English |
| last_indexed | 2024-03-11T06:05:18Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nanomaterials |
| spelling | doaj.art-983dcae6b79b447c999f7d127b7c82be2023-11-17T13:01:09ZengMDPI AGNanomaterials2079-49912023-03-01136107210.3390/nano13061072Role of Polyanions and Surfactant Head Group in the Formation of Polymer–Colloid NanocontainersElmira A. Vasilieva0Darya A. Kuznetsova1Farida G. Valeeva2Denis M. Kuznetsov3Lucia Ya. Zakharova4Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences, Arbuzov Str. 8, 420088 Kazan, RussiaArbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences, Arbuzov Str. 8, 420088 Kazan, RussiaArbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences, Arbuzov Str. 8, 420088 Kazan, RussiaArbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences, Arbuzov Str. 8, 420088 Kazan, RussiaArbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences, Arbuzov Str. 8, 420088 Kazan, RussiaObjectives. This study was aimed at the investigation of the supramolecular systems based on cationic surfactants bearing cyclic head groups (imidazolium and pyrrolidinium) and polyanions (polyacrylic acid (PAA) and human serum albumin (HSA)), and factors governing their structural behavior to create functional nanosystems with controlled properties. Research hypothesis. Mixed PE–surfactant complexes based on oppositely charged species are characterized by multifactor behavior strongly affected by the nature of both components. It was expected that the transition from a single surfactant solution to an admixture with PE might provide synergetic effects on structural characteristics and functional activity. To test this assumption, the concentration thresholds of aggregation, dimensional and charge characteristics, and solubilization capacity of amphiphiles in the presence of PEs have been determined by tensiometry, fluorescence and UV-visible spectroscopy, and dynamic and electrophoretic light scattering. Results. The formation of mixed surfactant–PAA aggregates with a hydrodynamic diameter of 100–180 nm has been shown. Polyanion additives led to a decrease in the critical micelle concentration of surfactants by two orders of magnitude (from 1 mM to 0.01 mM). A gradual increase in the zeta potential of HAS–surfactant systems from negative to positive value indicates that the electrostatic mechanism contributes to the binding of components. Additionally, 3D and conventional fluorescence spectroscopy showed that imidazolium surfactant had little effect on HSA conformation, and component binding occurs due to hydrogen bonding and Van der Waals interactions through the tryptophan amino acid residue of the protein. Surfactant–polyanion nanostructures improve the solubility of lipophilic medicines such as Warfarin, Amphotericin B, and Meloxicam. Perspectives. Surfactant–PE composition demonstrated beneficial solubilization activity and can be recommended for the construction of nanocontainers for hydrophobic drugs, with their efficacy tuned by the variation in surfactant head group and the nature of polyanions.https://www.mdpi.com/2079-4991/13/6/1072polymer–colloid complexsurfactantpolyelectrolytehuman serum albuminpolyacrylic acidcritical aggregation concentration |
| spellingShingle | Elmira A. Vasilieva Darya A. Kuznetsova Farida G. Valeeva Denis M. Kuznetsov Lucia Ya. Zakharova Role of Polyanions and Surfactant Head Group in the Formation of Polymer–Colloid Nanocontainers Nanomaterials polymer–colloid complex surfactant polyelectrolyte human serum albumin polyacrylic acid critical aggregation concentration |
| title | Role of Polyanions and Surfactant Head Group in the Formation of Polymer–Colloid Nanocontainers |
| title_full | Role of Polyanions and Surfactant Head Group in the Formation of Polymer–Colloid Nanocontainers |
| title_fullStr | Role of Polyanions and Surfactant Head Group in the Formation of Polymer–Colloid Nanocontainers |
| title_full_unstemmed | Role of Polyanions and Surfactant Head Group in the Formation of Polymer–Colloid Nanocontainers |
| title_short | Role of Polyanions and Surfactant Head Group in the Formation of Polymer–Colloid Nanocontainers |
| title_sort | role of polyanions and surfactant head group in the formation of polymer colloid nanocontainers |
| topic | polymer–colloid complex surfactant polyelectrolyte human serum albumin polyacrylic acid critical aggregation concentration |
| url | https://www.mdpi.com/2079-4991/13/6/1072 |
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