Multiple cavities with halo sign in a case of invasive pulmonary aspergillosis during therapy for drug-induced hypersensitivity syndrome
A 67-year-old female with rheumatoid arthritis and asthma-chronic obstructive pulmonary disease overlap syndrome was admitted for drug-induced hypersensitivity syndrome (DIHS) caused by salazosulfapyridine. Human herpes virus 6 (HHV-6) variant B was strongly positive on peripheral blood. Multiple ca...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2017-01-01
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| Series: | Respiratory Medicine Case Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213007117300461 |
| _version_ | 1819095938148335616 |
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| author | Tomoo Ikari Katsura Nagai Masashi Ohe Toshiyuki Harada Yasushi Akiyama |
| author_facet | Tomoo Ikari Katsura Nagai Masashi Ohe Toshiyuki Harada Yasushi Akiyama |
| author_sort | Tomoo Ikari |
| collection | DOAJ |
| description | A 67-year-old female with rheumatoid arthritis and asthma-chronic obstructive pulmonary disease overlap syndrome was admitted for drug-induced hypersensitivity syndrome (DIHS) caused by salazosulfapyridine. Human herpes virus 6 (HHV-6) variant B was strongly positive on peripheral blood. Multiple cavities with ground grass opacities rapidly emerged predominantly in the upper and middle lobes. She was diagnosed with invasive pulmonary aspergillosis (IPA), and was treated successfully with antifungal agents. Therapeutic systemic corticosteroids, emphysematous change in the lungs, and the worsening of the patient's general condition due to DIHS were considered major contributing factor leading to IPA. HHV-6 reactivation could have an effect on clinical course of IPA. Cavities with halo sign would provide an early clue to IPA in non-neutropenic and immunosuppressive patients. |
| first_indexed | 2024-12-21T23:51:15Z |
| format | Article |
| id | doaj.art-983def5694ce4b44bc1223dce9064cfc |
| institution | Directory Open Access Journal |
| issn | 2213-0071 |
| language | English |
| last_indexed | 2024-12-21T23:51:15Z |
| publishDate | 2017-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Respiratory Medicine Case Reports |
| spelling | doaj.art-983def5694ce4b44bc1223dce9064cfc2022-12-21T18:45:55ZengElsevierRespiratory Medicine Case Reports2213-00712017-01-0121C12412810.1016/j.rmcr.2017.04.017Multiple cavities with halo sign in a case of invasive pulmonary aspergillosis during therapy for drug-induced hypersensitivity syndromeTomoo Ikari0Katsura Nagai1Masashi Ohe2Toshiyuki Harada3Yasushi Akiyama4Department of Respiratory Medicine, Center for Respiratory Diseases, JCHO Hokkaido Hospital, JapanDepartment of Respiratory Medicine, Center for Respiratory Diseases, JCHO Hokkaido Hospital, JapanDepartment of Connective Tissue Disease, JCHO Hokkaido Hospital, JapanDepartment of Respiratory Medicine, Center for Respiratory Diseases, JCHO Hokkaido Hospital, JapanDepartment of Respiratory Medicine, Center for Respiratory Diseases, JCHO Hokkaido Hospital, JapanA 67-year-old female with rheumatoid arthritis and asthma-chronic obstructive pulmonary disease overlap syndrome was admitted for drug-induced hypersensitivity syndrome (DIHS) caused by salazosulfapyridine. Human herpes virus 6 (HHV-6) variant B was strongly positive on peripheral blood. Multiple cavities with ground grass opacities rapidly emerged predominantly in the upper and middle lobes. She was diagnosed with invasive pulmonary aspergillosis (IPA), and was treated successfully with antifungal agents. Therapeutic systemic corticosteroids, emphysematous change in the lungs, and the worsening of the patient's general condition due to DIHS were considered major contributing factor leading to IPA. HHV-6 reactivation could have an effect on clinical course of IPA. Cavities with halo sign would provide an early clue to IPA in non-neutropenic and immunosuppressive patients.http://www.sciencedirect.com/science/article/pii/S2213007117300461Invasive pulmonary aspergillosisDrug-induced hypersensitivity syndromeHuman herpes virus 6 (HHV-6)Chronic obstructive pulmonary disease (COPD)Halo sign |
| spellingShingle | Tomoo Ikari Katsura Nagai Masashi Ohe Toshiyuki Harada Yasushi Akiyama Multiple cavities with halo sign in a case of invasive pulmonary aspergillosis during therapy for drug-induced hypersensitivity syndrome Respiratory Medicine Case Reports Invasive pulmonary aspergillosis Drug-induced hypersensitivity syndrome Human herpes virus 6 (HHV-6) Chronic obstructive pulmonary disease (COPD) Halo sign |
| title | Multiple cavities with halo sign in a case of invasive pulmonary aspergillosis during therapy for drug-induced hypersensitivity syndrome |
| title_full | Multiple cavities with halo sign in a case of invasive pulmonary aspergillosis during therapy for drug-induced hypersensitivity syndrome |
| title_fullStr | Multiple cavities with halo sign in a case of invasive pulmonary aspergillosis during therapy for drug-induced hypersensitivity syndrome |
| title_full_unstemmed | Multiple cavities with halo sign in a case of invasive pulmonary aspergillosis during therapy for drug-induced hypersensitivity syndrome |
| title_short | Multiple cavities with halo sign in a case of invasive pulmonary aspergillosis during therapy for drug-induced hypersensitivity syndrome |
| title_sort | multiple cavities with halo sign in a case of invasive pulmonary aspergillosis during therapy for drug induced hypersensitivity syndrome |
| topic | Invasive pulmonary aspergillosis Drug-induced hypersensitivity syndrome Human herpes virus 6 (HHV-6) Chronic obstructive pulmonary disease (COPD) Halo sign |
| url | http://www.sciencedirect.com/science/article/pii/S2213007117300461 |
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