Hollow Particles Obtained by Prilling and Supercritical Drying as a Potential Conformable Dressing for Chronic Wounds
The production of aerogels for different applications has been widely known, but the use of polysaccharide-based aerogels for pharmaceutical applications, specifically as drug carriers for wound healing, is being recently explored. The main focus of this work is the production and characterization o...
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MDPI AG
2023-06-01
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| Online Access: | https://www.mdpi.com/2310-2861/9/6/492 |
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| author | Maria Rosaria Sellitto Chiara Amante Rita Patrizia Aquino Paola Russo Rosalía Rodríguez-Dorado Monica Neagu Carlos A. García-González Renata Adami Pasquale Del Gaudio |
| author_facet | Maria Rosaria Sellitto Chiara Amante Rita Patrizia Aquino Paola Russo Rosalía Rodríguez-Dorado Monica Neagu Carlos A. García-González Renata Adami Pasquale Del Gaudio |
| author_sort | Maria Rosaria Sellitto |
| collection | DOAJ |
| description | The production of aerogels for different applications has been widely known, but the use of polysaccharide-based aerogels for pharmaceutical applications, specifically as drug carriers for wound healing, is being recently explored. The main focus of this work is the production and characterization of drug-loaded aerogel capsules through prilling in tandem with supercritical extraction. In particular, drug-loaded particles were produced by a recently developed inverse gelation method through prilling in a coaxial configuration. Particles were loaded with ketoprofen lysinate, which was used as a model drug. The core-shell particles manufactured by prilling were subjected to a supercritical drying process with CO<sub>2</sub> that led to capsules formed by a wide hollow cavity and a tunable thin aerogel layer (40 μm) made of alginate, which presented good textural properties in terms of porosity (89.9% and 95.3%) and a surface area up to 417.0 m<sup>2</sup>/g. Such properties allowed the hollow aerogel particles to absorb a high amount of wound fluid moving very quickly (less than 30 s) into a conformable hydrogel in the wound cavity, prolonging drug release (till 72 h) due to the in situ formed hydrogel that acted as a barrier to drug diffusion. |
| first_indexed | 2024-03-11T02:26:32Z |
| format | Article |
| id | doaj.art-983e78a233e0446c896e5883e9d9663d |
| institution | Directory Open Access Journal |
| issn | 2310-2861 |
| language | English |
| last_indexed | 2024-03-11T02:26:32Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Gels |
| spelling | doaj.art-983e78a233e0446c896e5883e9d9663d2023-11-18T10:32:42ZengMDPI AGGels2310-28612023-06-019649210.3390/gels9060492Hollow Particles Obtained by Prilling and Supercritical Drying as a Potential Conformable Dressing for Chronic WoundsMaria Rosaria Sellitto0Chiara Amante1Rita Patrizia Aquino2Paola Russo3Rosalía Rodríguez-Dorado4Monica Neagu5Carlos A. García-González6Renata Adami7Pasquale Del Gaudio8Department of Pharmacy, University of Salerno, 84084 Fisciano, SA, ItalyDepartment of Pharmacy, University of Salerno, 84084 Fisciano, SA, ItalyDepartment of Pharmacy, University of Salerno, 84084 Fisciano, SA, ItalyDepartment of Pharmacy, University of Salerno, 84084 Fisciano, SA, ItalyDepartment of Pharmacy, University of Salerno, 84084 Fisciano, SA, ItalyImmunology Department, Victor Babes National Institute of Pathology, 050096 Bucharest, RomaniaDepartment of Pharmacology, Pharmacy and Pharmaceutical Technology, R+D Pharma Group (GI-1645), Faculty of Pharmacy and Health Research Institute of Santiago de Compostela (IDIS), Universidade de Santiago de Compostela, E-15782 Santiago de Compostela, SpainDepartment of Physics “E. R. Caianiello”, University of Salerno, 84084 Fisciano, SA, ItalyDepartment of Pharmacy, University of Salerno, 84084 Fisciano, SA, ItalyThe production of aerogels for different applications has been widely known, but the use of polysaccharide-based aerogels for pharmaceutical applications, specifically as drug carriers for wound healing, is being recently explored. The main focus of this work is the production and characterization of drug-loaded aerogel capsules through prilling in tandem with supercritical extraction. In particular, drug-loaded particles were produced by a recently developed inverse gelation method through prilling in a coaxial configuration. Particles were loaded with ketoprofen lysinate, which was used as a model drug. The core-shell particles manufactured by prilling were subjected to a supercritical drying process with CO<sub>2</sub> that led to capsules formed by a wide hollow cavity and a tunable thin aerogel layer (40 μm) made of alginate, which presented good textural properties in terms of porosity (89.9% and 95.3%) and a surface area up to 417.0 m<sup>2</sup>/g. Such properties allowed the hollow aerogel particles to absorb a high amount of wound fluid moving very quickly (less than 30 s) into a conformable hydrogel in the wound cavity, prolonging drug release (till 72 h) due to the in situ formed hydrogel that acted as a barrier to drug diffusion.https://www.mdpi.com/2310-2861/9/6/492aerogel capsulesprillingsupercritical dryingketoprofen lysinewound dressing |
| spellingShingle | Maria Rosaria Sellitto Chiara Amante Rita Patrizia Aquino Paola Russo Rosalía Rodríguez-Dorado Monica Neagu Carlos A. García-González Renata Adami Pasquale Del Gaudio Hollow Particles Obtained by Prilling and Supercritical Drying as a Potential Conformable Dressing for Chronic Wounds Gels aerogel capsules prilling supercritical drying ketoprofen lysine wound dressing |
| title | Hollow Particles Obtained by Prilling and Supercritical Drying as a Potential Conformable Dressing for Chronic Wounds |
| title_full | Hollow Particles Obtained by Prilling and Supercritical Drying as a Potential Conformable Dressing for Chronic Wounds |
| title_fullStr | Hollow Particles Obtained by Prilling and Supercritical Drying as a Potential Conformable Dressing for Chronic Wounds |
| title_full_unstemmed | Hollow Particles Obtained by Prilling and Supercritical Drying as a Potential Conformable Dressing for Chronic Wounds |
| title_short | Hollow Particles Obtained by Prilling and Supercritical Drying as a Potential Conformable Dressing for Chronic Wounds |
| title_sort | hollow particles obtained by prilling and supercritical drying as a potential conformable dressing for chronic wounds |
| topic | aerogel capsules prilling supercritical drying ketoprofen lysine wound dressing |
| url | https://www.mdpi.com/2310-2861/9/6/492 |
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