A neonatal gnotobiotic pig model of human enterovirus 71 infection and associated immune responses

A neonatal gnotobiotic pig model of human enterovirus 71 infection and associated immune responses

Vaccine development and pathogenesis studies for human enterovirus 71 are limited by a lack of suitable animal models. Here, we report the development of a novel neonatal gnotobiotic pig model using the non-pig-adapted neurovirulent human enterovirus 71 strain BJ110, which has a C4 genotype. Porcine...

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Bibliographic Details
Main Authors: Xingdong Yang, Guohua Li, Ke Wen, Tammy Bui, Fangning Liu, Jacob Kocher, Bernard S Jortner, Marlice Vonck, Kevin Pelzer, Jie Deng, Runan Zhu, Yuyun Li, Yuan Qian, Lijuan Yuan
Format: Article
Language:English
Published: Taylor & Francis Group 2014-01-01
Series:Emerging Microbes and Infections
Subjects:
adaptive immune responses
animal model
human enterovirus 71
neonatal gnotobiotic pigs
pathogenesis
vaccine evaluation
Online Access:https://www.tandfonline.com/doi/10.1038/emi.2014.35

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https://www.tandfonline.com/doi/10.1038/emi.2014.35

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