Outcomes at 7 Years of Age of Former Very Preterm Neonates with Repeated Surfactant Treatment for Prolonged Respiratory Distress in the Neonatal Period
This study aimed at evaluating the 7-year outcomes of 118 very preterm newborns (VPNs, gestational age = 26 ± 1.4 w) involved in a randomized controlled trial. They presented neonatal respiratory distress (RDS), requiring ventilation for 14 ± 2 days post-natal age (PNA). A repeated instillation of 2...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-09-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/19/6220 |
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| author | Jean-Michel Hascoet Hélène Deforge Silvia Demoulin Jean-Charles Picaud Veronique Zupan Isabelle Ligi François Moreau Aurelie Labarre Patrick Daoud Laurent Storme Claude Bonabel Isabelle Hamon |
| author_facet | Jean-Michel Hascoet Hélène Deforge Silvia Demoulin Jean-Charles Picaud Veronique Zupan Isabelle Ligi François Moreau Aurelie Labarre Patrick Daoud Laurent Storme Claude Bonabel Isabelle Hamon |
| author_sort | Jean-Michel Hascoet |
| collection | DOAJ |
| description | This study aimed at evaluating the 7-year outcomes of 118 very preterm newborns (VPNs, gestational age = 26 ± 1.4 w) involved in a randomized controlled trial. They presented neonatal respiratory distress (RDS), requiring ventilation for 14 ± 2 days post-natal age (PNA). A repeated instillation of 200 mg/kg poractant alfa (SURF) did not improve early bronchopulmonary dysplasia, but the SURF infants needed less re-hospitalization than the controls for respiratory problems at 1- and 2-year PNA. There was no growth difference at 7.1 ± 0.3 years between 41 SURF infants and 36 controls (80% of the eligible children), and 7.9% SURF infants vs. 28.6% controls presented asthma (<i>p</i> = 0.021). The children underwent cognitive assessment (WISC IV) and pulmonary function testing (PFT), measuring their spirometry, lung volume, and airway resistance. The spirometry measures showed differences (<i>p</i> < 0.05) between the SURF infants and the controls (mean ± standard deviation (median z-score)) for FEV1 (L/s) (1.188 ± 0.690(−0.803) vs. 1.080 ± 0.243 (−1.446)); FEV1 after betamimetics (1.244 ± 0.183(−0.525) vs. 1.091 ± 0.20(−1.342)); FVC (L) (1.402 ± 0.217 (−0.406) vs. 1.265 ± 0.267 (−1.141)), and FVC after betamimetics (1.452 ± 0.237 (−0.241) vs. 1.279 ± 0.264 (−1.020)). PFT showed no differences in the volumes or airway resistance. The global IQ median (interquartile range) was 89 (82:99) vs. 89 (76:98), with 61% of the children >85 in both groups. Repeated surfactant treatment in VPNs presenting severe RDS led to the attenuation of early lung injuries, with an impact on long-term pulmonary sequelae, without differences in neurodevelopmental outcomes. |
| first_indexed | 2024-03-10T21:41:55Z |
| format | Article |
| id | doaj.art-983f4129796043198b424d546a59952f |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T21:41:55Z |
| publishDate | 2023-09-01 |
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| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-983f4129796043198b424d546a59952f2023-11-19T14:35:46ZengMDPI AGJournal of Clinical Medicine2077-03832023-09-011219622010.3390/jcm12196220Outcomes at 7 Years of Age of Former Very Preterm Neonates with Repeated Surfactant Treatment for Prolonged Respiratory Distress in the Neonatal PeriodJean-Michel Hascoet0Hélène Deforge1Silvia Demoulin2Jean-Charles Picaud3Veronique Zupan4Isabelle Ligi5François Moreau6Aurelie Labarre7Patrick Daoud8Laurent Storme9Claude Bonabel10Isabelle Hamon11DevAH Research Unit, Lorraine University, 54500 Vandoeuvre, FranceDevAH Research Unit, Lorraine University, 54500 Vandoeuvre, FranceDevAH Research Unit, Lorraine University, 54500 Vandoeuvre, FranceService de Néonatologie et de Réanimation Néonatale, Hospices Civils de Lyon, Hôpital de la Croix Rousse, 69004 Lyon, FranceService de Réanimation Néonatale, Hôpital A. Béclère, 92141 Clamart, FranceService de Médecine et Réanimation Néonatale, Centre Hospitalier Universitaire La Conception, 13385 Marseille, FranceService de Médecine Néonatale, Surveillance Continue et Réanimation Pédiatrique Polyvalente, Centre Hospitalier Universitaire Amiens-Picardie, 80000 Amiens, FranceUnité de Réanimation Pédiatrique et Néonatale, Centre Hospitalier Universitaire Charles Nicolle, 76000 Rouen, FranceDépartement Femmes/Enfants, Centre Hospitalier Intercommunal A Grégoire, 93100 Montreuil, FranceSecteur Réanimation Néonatale, Service de Médecine Néonatale, Centre Hospitalier Régional Universitaire, 59037 Lille, FranceService Exploration Fonctionelle Respiratoire, Centre Hospitalier Universitaire, 54500 Vandoeuvre, FranceDevAH Research Unit, Lorraine University, 54500 Vandoeuvre, FranceThis study aimed at evaluating the 7-year outcomes of 118 very preterm newborns (VPNs, gestational age = 26 ± 1.4 w) involved in a randomized controlled trial. They presented neonatal respiratory distress (RDS), requiring ventilation for 14 ± 2 days post-natal age (PNA). A repeated instillation of 200 mg/kg poractant alfa (SURF) did not improve early bronchopulmonary dysplasia, but the SURF infants needed less re-hospitalization than the controls for respiratory problems at 1- and 2-year PNA. There was no growth difference at 7.1 ± 0.3 years between 41 SURF infants and 36 controls (80% of the eligible children), and 7.9% SURF infants vs. 28.6% controls presented asthma (<i>p</i> = 0.021). The children underwent cognitive assessment (WISC IV) and pulmonary function testing (PFT), measuring their spirometry, lung volume, and airway resistance. The spirometry measures showed differences (<i>p</i> < 0.05) between the SURF infants and the controls (mean ± standard deviation (median z-score)) for FEV1 (L/s) (1.188 ± 0.690(−0.803) vs. 1.080 ± 0.243 (−1.446)); FEV1 after betamimetics (1.244 ± 0.183(−0.525) vs. 1.091 ± 0.20(−1.342)); FVC (L) (1.402 ± 0.217 (−0.406) vs. 1.265 ± 0.267 (−1.141)), and FVC after betamimetics (1.452 ± 0.237 (−0.241) vs. 1.279 ± 0.264 (−1.020)). PFT showed no differences in the volumes or airway resistance. The global IQ median (interquartile range) was 89 (82:99) vs. 89 (76:98), with 61% of the children >85 in both groups. Repeated surfactant treatment in VPNs presenting severe RDS led to the attenuation of early lung injuries, with an impact on long-term pulmonary sequelae, without differences in neurodevelopmental outcomes.https://www.mdpi.com/2077-0383/12/19/6220extreme prematuritysurfactantoutcomechildrenlongitudinal studypulmonary function testing |
| spellingShingle | Jean-Michel Hascoet Hélène Deforge Silvia Demoulin Jean-Charles Picaud Veronique Zupan Isabelle Ligi François Moreau Aurelie Labarre Patrick Daoud Laurent Storme Claude Bonabel Isabelle Hamon Outcomes at 7 Years of Age of Former Very Preterm Neonates with Repeated Surfactant Treatment for Prolonged Respiratory Distress in the Neonatal Period Journal of Clinical Medicine extreme prematurity surfactant outcome children longitudinal study pulmonary function testing |
| title | Outcomes at 7 Years of Age of Former Very Preterm Neonates with Repeated Surfactant Treatment for Prolonged Respiratory Distress in the Neonatal Period |
| title_full | Outcomes at 7 Years of Age of Former Very Preterm Neonates with Repeated Surfactant Treatment for Prolonged Respiratory Distress in the Neonatal Period |
| title_fullStr | Outcomes at 7 Years of Age of Former Very Preterm Neonates with Repeated Surfactant Treatment for Prolonged Respiratory Distress in the Neonatal Period |
| title_full_unstemmed | Outcomes at 7 Years of Age of Former Very Preterm Neonates with Repeated Surfactant Treatment for Prolonged Respiratory Distress in the Neonatal Period |
| title_short | Outcomes at 7 Years of Age of Former Very Preterm Neonates with Repeated Surfactant Treatment for Prolonged Respiratory Distress in the Neonatal Period |
| title_sort | outcomes at 7 years of age of former very preterm neonates with repeated surfactant treatment for prolonged respiratory distress in the neonatal period |
| topic | extreme prematurity surfactant outcome children longitudinal study pulmonary function testing |
| url | https://www.mdpi.com/2077-0383/12/19/6220 |
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