Identification of Histopathological Biomarkers in Fatal Cases of Coronavirus Disease: A Study on Lung Tissue
We aimed to evaluate the primary lung postmortem macro- and microscopic biomarkers and factors associated with diffuse alveolar damage in patients with fatal coronavirus (COVID-19). We retrospectively analyzed lung tissue collected from autopsies performed in Cluj-Napoca, Romania, between April 2020...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/13/12/2039 |
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| author | Ioana-Andreea Gheban-Roșca Bogdan-Alexandru Gheban Bogdan Pop Daniela-Cristina Mironescu Vasile Costel Siserman Elena Mihaela Jianu Tudor Drugan Sorana D. Bolboacă |
| author_facet | Ioana-Andreea Gheban-Roșca Bogdan-Alexandru Gheban Bogdan Pop Daniela-Cristina Mironescu Vasile Costel Siserman Elena Mihaela Jianu Tudor Drugan Sorana D. Bolboacă |
| author_sort | Ioana-Andreea Gheban-Roșca |
| collection | DOAJ |
| description | We aimed to evaluate the primary lung postmortem macro- and microscopic biomarkers and factors associated with diffuse alveolar damage in patients with fatal coronavirus (COVID-19). We retrospectively analyzed lung tissue collected from autopsies performed in Cluj-Napoca, Romania, between April 2020 and April 2021 on patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We examined 79 patients with confirmed SARS-CoV-2 infection, ages 34 to 96 years, split into two groups using the cut-off value of 70 years. Arterial hypertension (38%) and type 2 diabetes mellitus (19%) were the most common comorbidities with similar distribution between groups (<i>p</i>-values > 0.14). Macroscopically, bloody exudate was more frequently observed among patients < 70 years (33/36 vs. 29/43, <i>p</i>-value = 0.0091). Diffuse alveolar damage (53.1%) was similarly observed among the evaluated groups (<i>p</i>-value = 0.1354). Histopathological biomarkers of alveolar edema in 83.5% of patients, interstitial pneumonia in 74.7%, and microthrombi in 39.2% of cases were most frequently observed. Half of the evaluated lungs had an Ashcroft score of up to 2 and an alveolar air capacity of up to 12.5%. Bronchopneumonia (11/43 vs. 3/36, <i>p</i>-value = 0.0456) and interstitial edema (9/43 vs. 2/36, <i>p</i>-value = 0.0493) were significantly more frequent in older patients. Age (median: 67.5 vs. 77 years, <i>p</i>-value = 0.023) and infection with the beta variant of the virus (<i>p</i>-value = 0.0071) proved to be significant factors associated with diffuse alveolar damage. |
| first_indexed | 2024-03-11T02:34:56Z |
| format | Article |
| id | doaj.art-98411e262c9643d58745112ed2ca7438 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-11T02:34:56Z |
| publishDate | 2023-06-01 |
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| series | Diagnostics |
| spelling | doaj.art-98411e262c9643d58745112ed2ca74382023-11-18T10:00:15ZengMDPI AGDiagnostics2075-44182023-06-011312203910.3390/diagnostics13122039Identification of Histopathological Biomarkers in Fatal Cases of Coronavirus Disease: A Study on Lung TissueIoana-Andreea Gheban-Roșca0Bogdan-Alexandru Gheban1Bogdan Pop2Daniela-Cristina Mironescu3Vasile Costel Siserman4Elena Mihaela Jianu5Tudor Drugan6Sorana D. Bolboacă7Department of Medical Informatics and Biostatistics, Iuliu Hațieganu University of Medicine and Pharmacy, 400349 Cluj-Napoca, RomaniaRouen University Hospital—Charles-Nicolle, 76000 Rouen, FranceThe Oncology Institute “Prof. Dr. Ion Chiricuță”, 400015 Cluj-Napoca, RomaniaInstitute of Legal Medicine, 400006 Cluj-Napoca, RomaniaInstitute of Legal Medicine, 400006 Cluj-Napoca, RomaniaDepartment of Histology, Iuliu Hațieganu University of Medicine and Pharmacy, 400347 Cluj-Napoca, RomaniaDepartment of Medical Informatics and Biostatistics, Iuliu Hațieganu University of Medicine and Pharmacy, 400349 Cluj-Napoca, RomaniaDepartment of Medical Informatics and Biostatistics, Iuliu Hațieganu University of Medicine and Pharmacy, 400349 Cluj-Napoca, RomaniaWe aimed to evaluate the primary lung postmortem macro- and microscopic biomarkers and factors associated with diffuse alveolar damage in patients with fatal coronavirus (COVID-19). We retrospectively analyzed lung tissue collected from autopsies performed in Cluj-Napoca, Romania, between April 2020 and April 2021 on patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We examined 79 patients with confirmed SARS-CoV-2 infection, ages 34 to 96 years, split into two groups using the cut-off value of 70 years. Arterial hypertension (38%) and type 2 diabetes mellitus (19%) were the most common comorbidities with similar distribution between groups (<i>p</i>-values > 0.14). Macroscopically, bloody exudate was more frequently observed among patients < 70 years (33/36 vs. 29/43, <i>p</i>-value = 0.0091). Diffuse alveolar damage (53.1%) was similarly observed among the evaluated groups (<i>p</i>-value = 0.1354). Histopathological biomarkers of alveolar edema in 83.5% of patients, interstitial pneumonia in 74.7%, and microthrombi in 39.2% of cases were most frequently observed. Half of the evaluated lungs had an Ashcroft score of up to 2 and an alveolar air capacity of up to 12.5%. Bronchopneumonia (11/43 vs. 3/36, <i>p</i>-value = 0.0456) and interstitial edema (9/43 vs. 2/36, <i>p</i>-value = 0.0493) were significantly more frequent in older patients. Age (median: 67.5 vs. 77 years, <i>p</i>-value = 0.023) and infection with the beta variant of the virus (<i>p</i>-value = 0.0071) proved to be significant factors associated with diffuse alveolar damage.https://www.mdpi.com/2075-4418/13/12/2039histopathology biomarkersevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)coronavirus disease (COVID-19)autopsylung |
| spellingShingle | Ioana-Andreea Gheban-Roșca Bogdan-Alexandru Gheban Bogdan Pop Daniela-Cristina Mironescu Vasile Costel Siserman Elena Mihaela Jianu Tudor Drugan Sorana D. Bolboacă Identification of Histopathological Biomarkers in Fatal Cases of Coronavirus Disease: A Study on Lung Tissue Diagnostics histopathology biomarker severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) coronavirus disease (COVID-19) autopsy lung |
| title | Identification of Histopathological Biomarkers in Fatal Cases of Coronavirus Disease: A Study on Lung Tissue |
| title_full | Identification of Histopathological Biomarkers in Fatal Cases of Coronavirus Disease: A Study on Lung Tissue |
| title_fullStr | Identification of Histopathological Biomarkers in Fatal Cases of Coronavirus Disease: A Study on Lung Tissue |
| title_full_unstemmed | Identification of Histopathological Biomarkers in Fatal Cases of Coronavirus Disease: A Study on Lung Tissue |
| title_short | Identification of Histopathological Biomarkers in Fatal Cases of Coronavirus Disease: A Study on Lung Tissue |
| title_sort | identification of histopathological biomarkers in fatal cases of coronavirus disease a study on lung tissue |
| topic | histopathology biomarker severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) coronavirus disease (COVID-19) autopsy lung |
| url | https://www.mdpi.com/2075-4418/13/12/2039 |
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