Distinct Substrate Specificities and Electron-Donating Systems of Fungal Lytic Polysaccharide Monooxygenases
Lytic polysaccharide monooxygenases (LPMOs) are powerful enzymes that oxidatively cleave glycosidic bonds in polysaccharides. The ability of these copper enzymes to boost the degradation of lignocellulose has greatly stimulated research efforts and biocatalytic applications within the biorefinery fi...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-05-01
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| Series: | Frontiers in Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fmicb.2018.01080/full |
| _version_ | 1819097331294797824 |
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| author | Matthias Frommhagen Adrie H. Westphal Willem J. H. van Berkel Mirjam A. Kabel |
| author_facet | Matthias Frommhagen Adrie H. Westphal Willem J. H. van Berkel Mirjam A. Kabel |
| author_sort | Matthias Frommhagen |
| collection | DOAJ |
| description | Lytic polysaccharide monooxygenases (LPMOs) are powerful enzymes that oxidatively cleave glycosidic bonds in polysaccharides. The ability of these copper enzymes to boost the degradation of lignocellulose has greatly stimulated research efforts and biocatalytic applications within the biorefinery field. Initially found as oxidizing recalcitrant substrates, such as chitin and cellulose, it is now clear that LPMOs cleave a broad range of oligo- and poly-saccharides and make use of various electron-donating systems. Herein, substrate specificities and electron-donating systems of fungal LPMOs are summarized. A closer look at LPMOs as part of the fungal enzyme machinery might provide insights into their role in fungal growth and plant-pathogen interactions to further stimulate the search for novel LPMO applications. |
| first_indexed | 2024-12-22T00:13:23Z |
| format | Article |
| id | doaj.art-98417c829c9f431cbf3409886bf9aa38 |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-12-22T00:13:23Z |
| publishDate | 2018-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-98417c829c9f431cbf3409886bf9aa382022-12-21T18:45:22ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2018-05-01910.3389/fmicb.2018.01080358610Distinct Substrate Specificities and Electron-Donating Systems of Fungal Lytic Polysaccharide MonooxygenasesMatthias Frommhagen0Adrie H. Westphal1Willem J. H. van Berkel2Mirjam A. Kabel3Laboratory of Food Chemistry, Wageningen University and Research, Wageningen, NetherlandsLaboratory of Biochemistry, Wageningen University and Research, Wageningen, NetherlandsLaboratory of Biochemistry, Wageningen University and Research, Wageningen, NetherlandsLaboratory of Food Chemistry, Wageningen University and Research, Wageningen, NetherlandsLytic polysaccharide monooxygenases (LPMOs) are powerful enzymes that oxidatively cleave glycosidic bonds in polysaccharides. The ability of these copper enzymes to boost the degradation of lignocellulose has greatly stimulated research efforts and biocatalytic applications within the biorefinery field. Initially found as oxidizing recalcitrant substrates, such as chitin and cellulose, it is now clear that LPMOs cleave a broad range of oligo- and poly-saccharides and make use of various electron-donating systems. Herein, substrate specificities and electron-donating systems of fungal LPMOs are summarized. A closer look at LPMOs as part of the fungal enzyme machinery might provide insights into their role in fungal growth and plant-pathogen interactions to further stimulate the search for novel LPMO applications.https://www.frontiersin.org/article/10.3389/fmicb.2018.01080/fullLPMOlytic polysaccharide monooxygenasesubstrate specificityC1/C4-oxidationelectron donorreducing agent |
| spellingShingle | Matthias Frommhagen Adrie H. Westphal Willem J. H. van Berkel Mirjam A. Kabel Distinct Substrate Specificities and Electron-Donating Systems of Fungal Lytic Polysaccharide Monooxygenases Frontiers in Microbiology LPMO lytic polysaccharide monooxygenase substrate specificity C1/C4-oxidation electron donor reducing agent |
| title | Distinct Substrate Specificities and Electron-Donating Systems of Fungal Lytic Polysaccharide Monooxygenases |
| title_full | Distinct Substrate Specificities and Electron-Donating Systems of Fungal Lytic Polysaccharide Monooxygenases |
| title_fullStr | Distinct Substrate Specificities and Electron-Donating Systems of Fungal Lytic Polysaccharide Monooxygenases |
| title_full_unstemmed | Distinct Substrate Specificities and Electron-Donating Systems of Fungal Lytic Polysaccharide Monooxygenases |
| title_short | Distinct Substrate Specificities and Electron-Donating Systems of Fungal Lytic Polysaccharide Monooxygenases |
| title_sort | distinct substrate specificities and electron donating systems of fungal lytic polysaccharide monooxygenases |
| topic | LPMO lytic polysaccharide monooxygenase substrate specificity C1/C4-oxidation electron donor reducing agent |
| url | https://www.frontiersin.org/article/10.3389/fmicb.2018.01080/full |
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