BCI-activated electrical stimulation in children with perinatal stroke and hemiparesis: A pilot study
BackgroundPerinatal stroke (PS) causes most hemiparetic cerebral palsy (CP) and results in lifelong disability. Children with severe hemiparesis have limited rehabilitation options. Brain computer interface- activated functional electrical stimulation (BCI-FES) of target muscles may enhance upper ex...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Human Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnhum.2023.1006242/full |
| _version_ | 1827987869270016000 |
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| author | Zeanna Jadavji Zeanna Jadavji Zeanna Jadavji Adam Kirton Adam Kirton Adam Kirton Megan J. Metzler Ephrem Zewdie Ephrem Zewdie Ephrem Zewdie |
| author_facet | Zeanna Jadavji Zeanna Jadavji Zeanna Jadavji Adam Kirton Adam Kirton Adam Kirton Megan J. Metzler Ephrem Zewdie Ephrem Zewdie Ephrem Zewdie |
| author_sort | Zeanna Jadavji |
| collection | DOAJ |
| description | BackgroundPerinatal stroke (PS) causes most hemiparetic cerebral palsy (CP) and results in lifelong disability. Children with severe hemiparesis have limited rehabilitation options. Brain computer interface- activated functional electrical stimulation (BCI-FES) of target muscles may enhance upper extremity function in hemiparetic adults. We conducted a pilot clinical trial to assess the safety and feasibility of BCI-FES in children with hemiparetic CP.MethodsThirteen participants (mean age = 12.2 years, 31% female) were recruited from a population-based cohort. Inclusion criteria were: (1) MRI-confirmed PS, (2) disabling hemiparetic CP, (3) age 6–18 years, (4) informed consent/assent. Those with neurological comorbidities or unstable epilepsy were excluded. Participants attended two BCI sessions: training and rehabilitation. They wore an EEG-BCI headset and two forearm extensor stimulation electrodes. Participants’ imagination of wrist extension was classified on EEG, after which muscle stimulation and visual feedback were provided when the correct visualization was detected.ResultsNo serious adverse events or dropouts occurred. The most common complaints were mild headache, headset discomfort and muscle fatigue. Children ranked the experience as comparable to a long car ride and none reported as unpleasant. Sessions lasted a mean of 87 min with 33 min of stimulation delivered. Mean classification accuracies were (M = 78.78%, SD = 9.97) for training and (M = 73.48, SD = 12.41) for rehabilitation. Mean Cohen’s Kappa across rehabilitation trials was M = 0.43, SD = 0.29, range = 0.019–1.00, suggesting BCI competency.ConclusionBrain computer interface-FES was well -tolerated and feasible in children with hemiparesis. This paves the way for clinical trials to optimize approaches and test efficacy. |
| first_indexed | 2024-04-09T23:54:51Z |
| format | Article |
| id | doaj.art-984377f9b85c4470a7049d723f0493b1 |
| institution | Directory Open Access Journal |
| issn | 1662-5161 |
| language | English |
| last_indexed | 2024-04-09T23:54:51Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Human Neuroscience |
| spelling | doaj.art-984377f9b85c4470a7049d723f0493b12023-03-17T04:26:16ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612023-03-011710.3389/fnhum.2023.10062421006242BCI-activated electrical stimulation in children with perinatal stroke and hemiparesis: A pilot studyZeanna Jadavji0Zeanna Jadavji1Zeanna Jadavji2Adam Kirton3Adam Kirton4Adam Kirton5Megan J. Metzler6Ephrem Zewdie7Ephrem Zewdie8Ephrem Zewdie9Cumming School of Medicine, University of Calgary, Calgary, AB, CanadaDepartment of Pediatrics, University of Calgary, Calgary, AB, CanadaAlberta Children’s Hospital Research Institute, Calgary, AB, CanadaCumming School of Medicine, University of Calgary, Calgary, AB, CanadaAlberta Children’s Hospital Research Institute, Calgary, AB, CanadaDepartment of Pediatrics, Alberta Children’s Hospital, Calgary, AB, CanadaDepartment of Clinical Neurosciences, Alberta Children’s Hospital, Calgary, AB, CanadaCumming School of Medicine, University of Calgary, Calgary, AB, CanadaDepartment of Pediatrics, University of Calgary, Calgary, AB, CanadaAlberta Children’s Hospital Research Institute, Calgary, AB, CanadaBackgroundPerinatal stroke (PS) causes most hemiparetic cerebral palsy (CP) and results in lifelong disability. Children with severe hemiparesis have limited rehabilitation options. Brain computer interface- activated functional electrical stimulation (BCI-FES) of target muscles may enhance upper extremity function in hemiparetic adults. We conducted a pilot clinical trial to assess the safety and feasibility of BCI-FES in children with hemiparetic CP.MethodsThirteen participants (mean age = 12.2 years, 31% female) were recruited from a population-based cohort. Inclusion criteria were: (1) MRI-confirmed PS, (2) disabling hemiparetic CP, (3) age 6–18 years, (4) informed consent/assent. Those with neurological comorbidities or unstable epilepsy were excluded. Participants attended two BCI sessions: training and rehabilitation. They wore an EEG-BCI headset and two forearm extensor stimulation electrodes. Participants’ imagination of wrist extension was classified on EEG, after which muscle stimulation and visual feedback were provided when the correct visualization was detected.ResultsNo serious adverse events or dropouts occurred. The most common complaints were mild headache, headset discomfort and muscle fatigue. Children ranked the experience as comparable to a long car ride and none reported as unpleasant. Sessions lasted a mean of 87 min with 33 min of stimulation delivered. Mean classification accuracies were (M = 78.78%, SD = 9.97) for training and (M = 73.48, SD = 12.41) for rehabilitation. Mean Cohen’s Kappa across rehabilitation trials was M = 0.43, SD = 0.29, range = 0.019–1.00, suggesting BCI competency.ConclusionBrain computer interface-FES was well -tolerated and feasible in children with hemiparesis. This paves the way for clinical trials to optimize approaches and test efficacy.https://www.frontiersin.org/articles/10.3389/fnhum.2023.1006242/fullperinatal strokecerebral palsyelectrical stimulation (ES)brain computer interfacerehabilitation |
| spellingShingle | Zeanna Jadavji Zeanna Jadavji Zeanna Jadavji Adam Kirton Adam Kirton Adam Kirton Megan J. Metzler Ephrem Zewdie Ephrem Zewdie Ephrem Zewdie BCI-activated electrical stimulation in children with perinatal stroke and hemiparesis: A pilot study Frontiers in Human Neuroscience perinatal stroke cerebral palsy electrical stimulation (ES) brain computer interface rehabilitation |
| title | BCI-activated electrical stimulation in children with perinatal stroke and hemiparesis: A pilot study |
| title_full | BCI-activated electrical stimulation in children with perinatal stroke and hemiparesis: A pilot study |
| title_fullStr | BCI-activated electrical stimulation in children with perinatal stroke and hemiparesis: A pilot study |
| title_full_unstemmed | BCI-activated electrical stimulation in children with perinatal stroke and hemiparesis: A pilot study |
| title_short | BCI-activated electrical stimulation in children with perinatal stroke and hemiparesis: A pilot study |
| title_sort | bci activated electrical stimulation in children with perinatal stroke and hemiparesis a pilot study |
| topic | perinatal stroke cerebral palsy electrical stimulation (ES) brain computer interface rehabilitation |
| url | https://www.frontiersin.org/articles/10.3389/fnhum.2023.1006242/full |
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