Loss-of-function mutations in MYO15A and OTOF cause non-syndromic hearing loss in two Yemeni families

Loss-of-function mutations in MYO15A and OTOF cause non-syndromic hearing loss in two Yemeni families

Abstract Background Hearing loss is a rare hereditary deficit that is rather common among consanguineous populations. Autosomal recessive non-syndromic hearing loss is the predominant form of hearing loss worldwide. Although prevalent, hearing loss is extremely heterogeneous and poses a pitfall in t...

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Bibliographic Details
Main Authors: Maria Asaad, Mona Mahfood, Abdullah Al Mutery, Abdelaziz Tlili
Format: Article
Language:English
Published: BMC 2023-05-01
Series:Human Genomics
Subjects:
Non-syndromic hearing loss
Frameshift mutation
Splice site mutation
MYO15A gene
OTOF gene
Clinical exome sequencing
Online Access:https://doi.org/10.1186/s40246-023-00489-1

Internet

https://doi.org/10.1186/s40246-023-00489-1

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