Miro1 – the missing link to peroxisome motility
Peroxisomes are ubiquitous, highly dynamic, multifunctional compartments in eukaryotic cells, which perform key roles in cellular lipid metabolism and redox balance. Like other membrane-bound organelles, peroxisomes must move in the cellular landscape to perform localized functions, interact with ot...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2018-07-01
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| Series: | Communicative & Integrative Biology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/19420889.2018.1526573 |
| _version_ | 1818360703459786752 |
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| author | Inês G. Castro Michael Schrader |
| author_facet | Inês G. Castro Michael Schrader |
| author_sort | Inês G. Castro |
| collection | DOAJ |
| description | Peroxisomes are ubiquitous, highly dynamic, multifunctional compartments in eukaryotic cells, which perform key roles in cellular lipid metabolism and redox balance. Like other membrane-bound organelles, peroxisomes must move in the cellular landscape to perform localized functions, interact with other organelles and to properly distribute during cell division. However, our current knowledge of peroxisome motility in mammalian cells is still very limited. Recently, three independent studies have identified Miro1 as a regulator of peroxisome motility in mammalian cells. In these studies, the authors show that Miro1 is targeted to peroxisomes in several cell lines, in a process that relies on its interaction with the peroxisomal chaperone Pex19. Interestingly, however, different conclusions are drawn about which Miro1 isoforms are targeted to peroxisomes, how it interacts with Pex19 and most importantly, the type of motility Miro1 is regulating. |
| first_indexed | 2024-12-13T21:05:00Z |
| format | Article |
| id | doaj.art-984545cf7c6047ee91231842b93d6a20 |
| institution | Directory Open Access Journal |
| issn | 1942-0889 |
| language | English |
| last_indexed | 2024-12-13T21:05:00Z |
| publishDate | 2018-07-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Communicative & Integrative Biology |
| spelling | doaj.art-984545cf7c6047ee91231842b93d6a202022-12-21T23:31:30ZengTaylor & Francis GroupCommunicative & Integrative Biology1942-08892018-07-0111410.1080/19420889.2018.15265731526573Miro1 – the missing link to peroxisome motilityInês G. Castro0Michael Schrader1Weizmann Institute of ScienceUniversity of ExeterPeroxisomes are ubiquitous, highly dynamic, multifunctional compartments in eukaryotic cells, which perform key roles in cellular lipid metabolism and redox balance. Like other membrane-bound organelles, peroxisomes must move in the cellular landscape to perform localized functions, interact with other organelles and to properly distribute during cell division. However, our current knowledge of peroxisome motility in mammalian cells is still very limited. Recently, three independent studies have identified Miro1 as a regulator of peroxisome motility in mammalian cells. In these studies, the authors show that Miro1 is targeted to peroxisomes in several cell lines, in a process that relies on its interaction with the peroxisomal chaperone Pex19. Interestingly, however, different conclusions are drawn about which Miro1 isoforms are targeted to peroxisomes, how it interacts with Pex19 and most importantly, the type of motility Miro1 is regulating.http://dx.doi.org/10.1080/19420889.2018.1526573Miro1peroxisomeorganelle motilitymicrotubuleactin |
| spellingShingle | Inês G. Castro Michael Schrader Miro1 – the missing link to peroxisome motility Communicative & Integrative Biology Miro1 peroxisome organelle motility microtubule actin |
| title | Miro1 – the missing link to peroxisome motility |
| title_full | Miro1 – the missing link to peroxisome motility |
| title_fullStr | Miro1 – the missing link to peroxisome motility |
| title_full_unstemmed | Miro1 – the missing link to peroxisome motility |
| title_short | Miro1 – the missing link to peroxisome motility |
| title_sort | miro1 the missing link to peroxisome motility |
| topic | Miro1 peroxisome organelle motility microtubule actin |
| url | http://dx.doi.org/10.1080/19420889.2018.1526573 |
| work_keys_str_mv | AT inesgcastro miro1themissinglinktoperoxisomemotility AT michaelschrader miro1themissinglinktoperoxisomemotility |