A Cellular Assay for the Identification and Characterization of Connexin Gap Junction Modulators

A Cellular Assay for the Identification and Characterization of Connexin Gap Junction Modulators

Connexin gap junctions (Cx GJs) enable the passage of small molecules and ions between cells and are therefore important for cell-to-cell communication. Their dysfunction is associated with diseases, and small molecules acting as modulators of GJs may therefore be useful as therapeutic drugs. To ide...

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Bibliographic Details
Main Authors: Azeem Danish, Robin Gedschold, Sonja Hinz, Anke C. Schiedel, Dominik Thimm, Peter Bedner, Christian Steinhäuser, Christa E. Müller
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:International Journal of Molecular Sciences
Subjects:
compound library
connexin-43
gap junctions
GloSensor luciferase
HeLa cells
screening
Online Access:https://www.mdpi.com/1422-0067/22/3/1417

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