The impact of high grade glial neoplasms on human cortical electrophysiology.
OBJECTIVE:The brain's functional architecture of interconnected network-related oscillatory patterns in discrete cortical regions has been well established with functional magnetic resonance imaging (fMRI) studies or direct cortical electrophysiology from electrodes placed on the surface of the...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2017-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5358752?pdf=render |
| _version_ | 1818315309204897792 |
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| author | S Kathleen Bandt Jarod L Roland Mrinal Pahwa Carl D Hacker David T Bundy Jonathan D Breshears Mohit Sharma Joshua S Shimony Eric C Leuthardt |
| author_facet | S Kathleen Bandt Jarod L Roland Mrinal Pahwa Carl D Hacker David T Bundy Jonathan D Breshears Mohit Sharma Joshua S Shimony Eric C Leuthardt |
| author_sort | S Kathleen Bandt |
| collection | DOAJ |
| description | OBJECTIVE:The brain's functional architecture of interconnected network-related oscillatory patterns in discrete cortical regions has been well established with functional magnetic resonance imaging (fMRI) studies or direct cortical electrophysiology from electrodes placed on the surface of the brain, or electrocorticography (ECoG). These resting state networks exhibit a robust functional architecture that persists through all stages of sleep and under anesthesia. While the stability of these networks provides a fundamental understanding of the organization of the brain, understanding how these regions can be perturbed is also critical in defining the brain's ability to adapt while learning and recovering from injury. METHODS:Patients undergoing an awake craniotomy for resection of a tumor were studied as a unique model of an evolving injury to help define how the cortical physiology and the associated networks were altered by the presence of an invasive brain tumor. RESULTS:This study demonstrates that there is a distinct pattern of alteration of cortical physiology in the setting of a malignant glioma. These changes lead to a physiologic sequestration and progressive synaptic homogeneity suggesting that a de-learning phenomenon occurs within the tumoral tissue compared to its surroundings. SIGNIFICANCE:These findings provide insight into how the brain accommodates a region of "defunctionalized" cortex. Additionally, these findings may have important implications for emerging techniques in brain mapping using endogenous cortical physiology. |
| first_indexed | 2024-12-13T09:03:29Z |
| format | Article |
| id | doaj.art-984673c2d9d244588c992db9bbda8e29 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-13T09:03:29Z |
| publishDate | 2017-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-984673c2d9d244588c992db9bbda8e292022-12-21T23:53:07ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01123e017344810.1371/journal.pone.0173448The impact of high grade glial neoplasms on human cortical electrophysiology.S Kathleen BandtJarod L RolandMrinal PahwaCarl D HackerDavid T BundyJonathan D BreshearsMohit SharmaJoshua S ShimonyEric C LeuthardtOBJECTIVE:The brain's functional architecture of interconnected network-related oscillatory patterns in discrete cortical regions has been well established with functional magnetic resonance imaging (fMRI) studies or direct cortical electrophysiology from electrodes placed on the surface of the brain, or electrocorticography (ECoG). These resting state networks exhibit a robust functional architecture that persists through all stages of sleep and under anesthesia. While the stability of these networks provides a fundamental understanding of the organization of the brain, understanding how these regions can be perturbed is also critical in defining the brain's ability to adapt while learning and recovering from injury. METHODS:Patients undergoing an awake craniotomy for resection of a tumor were studied as a unique model of an evolving injury to help define how the cortical physiology and the associated networks were altered by the presence of an invasive brain tumor. RESULTS:This study demonstrates that there is a distinct pattern of alteration of cortical physiology in the setting of a malignant glioma. These changes lead to a physiologic sequestration and progressive synaptic homogeneity suggesting that a de-learning phenomenon occurs within the tumoral tissue compared to its surroundings. SIGNIFICANCE:These findings provide insight into how the brain accommodates a region of "defunctionalized" cortex. Additionally, these findings may have important implications for emerging techniques in brain mapping using endogenous cortical physiology.http://europepmc.org/articles/PMC5358752?pdf=render |
| spellingShingle | S Kathleen Bandt Jarod L Roland Mrinal Pahwa Carl D Hacker David T Bundy Jonathan D Breshears Mohit Sharma Joshua S Shimony Eric C Leuthardt The impact of high grade glial neoplasms on human cortical electrophysiology. PLoS ONE |
| title | The impact of high grade glial neoplasms on human cortical electrophysiology. |
| title_full | The impact of high grade glial neoplasms on human cortical electrophysiology. |
| title_fullStr | The impact of high grade glial neoplasms on human cortical electrophysiology. |
| title_full_unstemmed | The impact of high grade glial neoplasms on human cortical electrophysiology. |
| title_short | The impact of high grade glial neoplasms on human cortical electrophysiology. |
| title_sort | impact of high grade glial neoplasms on human cortical electrophysiology |
| url | http://europepmc.org/articles/PMC5358752?pdf=render |
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