A spiral attractor network drives rhythmic locomotion
The joint activity of neural populations is high dimensional and complex. One strategy for reaching a tractable understanding of circuit function is to seek the simplest dynamical system that can account for the population activity. By imaging Aplysia’s pedal ganglion during fictive locomotion, here...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2017-08-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/27342 |
| _version_ | 1811202639409446912 |
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| author | Angela M Bruno William N Frost Mark D Humphries |
| author_facet | Angela M Bruno William N Frost Mark D Humphries |
| author_sort | Angela M Bruno |
| collection | DOAJ |
| description | The joint activity of neural populations is high dimensional and complex. One strategy for reaching a tractable understanding of circuit function is to seek the simplest dynamical system that can account for the population activity. By imaging Aplysia’s pedal ganglion during fictive locomotion, here we show that its population-wide activity arises from a low-dimensional spiral attractor. Evoking locomotion moved the population into a low-dimensional, periodic, decaying orbit - a spiral - in which it behaved as a true attractor, converging to the same orbit when evoked, and returning to that orbit after transient perturbation. We found the same attractor in every preparation, and could predict motor output directly from its orbit, yet individual neurons’ participation changed across consecutive locomotion bouts. From these results, we propose that only the low-dimensional dynamics for movement control, and not the high-dimensional population activity, are consistent within and between nervous systems. |
| first_indexed | 2024-04-12T02:43:09Z |
| format | Article |
| id | doaj.art-984852b94c2046f5992a684c7bb8f992 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-12T02:43:09Z |
| publishDate | 2017-08-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-984852b94c2046f5992a684c7bb8f9922022-12-22T03:51:16ZengeLife Sciences Publications LtdeLife2050-084X2017-08-01610.7554/eLife.27342A spiral attractor network drives rhythmic locomotionAngela M Bruno0William N Frost1Mark D Humphries2https://orcid.org/0000-0002-1906-2581Department of Neuroscience, The Chicago Medical School, Rosalind Franklin University of Medicine and Science, Illinois, United StatesDepartment of Cell Biology and Anatomy, The Chicago Medical School, Rosalind Franklin University of Medicine and Science, Illinois, United StatesFaculty of Biology, Medicine, and Health, University of Manchester, Manchester, United KingdomThe joint activity of neural populations is high dimensional and complex. One strategy for reaching a tractable understanding of circuit function is to seek the simplest dynamical system that can account for the population activity. By imaging Aplysia’s pedal ganglion during fictive locomotion, here we show that its population-wide activity arises from a low-dimensional spiral attractor. Evoking locomotion moved the population into a low-dimensional, periodic, decaying orbit - a spiral - in which it behaved as a true attractor, converging to the same orbit when evoked, and returning to that orbit after transient perturbation. We found the same attractor in every preparation, and could predict motor output directly from its orbit, yet individual neurons’ participation changed across consecutive locomotion bouts. From these results, we propose that only the low-dimensional dynamics for movement control, and not the high-dimensional population activity, are consistent within and between nervous systems.https://elifesciences.org/articles/27342Aplysia californicalocomotionpopulation dynamicsattractors |
| spellingShingle | Angela M Bruno William N Frost Mark D Humphries A spiral attractor network drives rhythmic locomotion eLife Aplysia californica locomotion population dynamics attractors |
| title | A spiral attractor network drives rhythmic locomotion |
| title_full | A spiral attractor network drives rhythmic locomotion |
| title_fullStr | A spiral attractor network drives rhythmic locomotion |
| title_full_unstemmed | A spiral attractor network drives rhythmic locomotion |
| title_short | A spiral attractor network drives rhythmic locomotion |
| title_sort | spiral attractor network drives rhythmic locomotion |
| topic | Aplysia californica locomotion population dynamics attractors |
| url | https://elifesciences.org/articles/27342 |
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