Antimicrobial Treatment of <i>Staphylococcus aureus</i> Biofilms
<i>Staphylococcus aureus</i> is a microorganism frequently associated with implant-related infections, owing to its ability to produce biofilms. These infections are difficult to treat because antimicrobials must cross the biofilm to effectively inhibit bacterial growth. Although some an...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/12/1/87 |
| _version_ | 1797446978811985920 |
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| author | Felipe Francisco Tuon Paula Hansen Suss Joao Paulo Telles Leticia Ramos Dantas Nícolas Henrique Borges Victoria Stadler Tasca Ribeiro |
| author_facet | Felipe Francisco Tuon Paula Hansen Suss Joao Paulo Telles Leticia Ramos Dantas Nícolas Henrique Borges Victoria Stadler Tasca Ribeiro |
| author_sort | Felipe Francisco Tuon |
| collection | DOAJ |
| description | <i>Staphylococcus aureus</i> is a microorganism frequently associated with implant-related infections, owing to its ability to produce biofilms. These infections are difficult to treat because antimicrobials must cross the biofilm to effectively inhibit bacterial growth. Although some antibiotics can penetrate the biofilm and reduce the bacterial load, it is important to understand that the results of routine sensitivity tests are not always valid for interpreting the activity of different drugs. In this review, a broad discussion on the genes involved in biofilm formation, quorum sensing, and antimicrobial activity in monotherapy and combination therapy is presented that should benefit researchers engaged in optimizing the treatment of infections associated with <i>S. aureus</i> biofilms. |
| first_indexed | 2024-03-09T13:48:19Z |
| format | Article |
| id | doaj.art-9848f8fb03d641ab948965de50662746 |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-09T13:48:19Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-9848f8fb03d641ab948965de506627462023-11-30T20:55:31ZengMDPI AGAntibiotics2079-63822023-01-011218710.3390/antibiotics12010087Antimicrobial Treatment of <i>Staphylococcus aureus</i> BiofilmsFelipe Francisco Tuon0Paula Hansen Suss1Joao Paulo Telles2Leticia Ramos Dantas3Nícolas Henrique Borges4Victoria Stadler Tasca Ribeiro5Laboratory of Emerging Infectious Diseases, School of Medicine, Pontifícia Universidade Católica do Paraná, Curitiba 80215-901, Paraná, BrazilLaboratory of Emerging Infectious Diseases, School of Medicine, Pontifícia Universidade Católica do Paraná, Curitiba 80215-901, Paraná, BrazilAC Camargo Cancer Center, Infectious Diseases Department, São Paulo 01525-001, São Paulo, BrazilLaboratory of Emerging Infectious Diseases, School of Medicine, Pontifícia Universidade Católica do Paraná, Curitiba 80215-901, Paraná, BrazilLaboratory of Emerging Infectious Diseases, School of Medicine, Pontifícia Universidade Católica do Paraná, Curitiba 80215-901, Paraná, BrazilLaboratory of Emerging Infectious Diseases, School of Medicine, Pontifícia Universidade Católica do Paraná, Curitiba 80215-901, Paraná, Brazil<i>Staphylococcus aureus</i> is a microorganism frequently associated with implant-related infections, owing to its ability to produce biofilms. These infections are difficult to treat because antimicrobials must cross the biofilm to effectively inhibit bacterial growth. Although some antibiotics can penetrate the biofilm and reduce the bacterial load, it is important to understand that the results of routine sensitivity tests are not always valid for interpreting the activity of different drugs. In this review, a broad discussion on the genes involved in biofilm formation, quorum sensing, and antimicrobial activity in monotherapy and combination therapy is presented that should benefit researchers engaged in optimizing the treatment of infections associated with <i>S. aureus</i> biofilms.https://www.mdpi.com/2079-6382/12/1/87antibioticbiofilminfections<i>Staphylococcus aureus</i>therapeutic antibiofilm |
| spellingShingle | Felipe Francisco Tuon Paula Hansen Suss Joao Paulo Telles Leticia Ramos Dantas Nícolas Henrique Borges Victoria Stadler Tasca Ribeiro Antimicrobial Treatment of <i>Staphylococcus aureus</i> Biofilms Antibiotics antibiotic biofilm infections <i>Staphylococcus aureus</i> therapeutic antibiofilm |
| title | Antimicrobial Treatment of <i>Staphylococcus aureus</i> Biofilms |
| title_full | Antimicrobial Treatment of <i>Staphylococcus aureus</i> Biofilms |
| title_fullStr | Antimicrobial Treatment of <i>Staphylococcus aureus</i> Biofilms |
| title_full_unstemmed | Antimicrobial Treatment of <i>Staphylococcus aureus</i> Biofilms |
| title_short | Antimicrobial Treatment of <i>Staphylococcus aureus</i> Biofilms |
| title_sort | antimicrobial treatment of i staphylococcus aureus i biofilms |
| topic | antibiotic biofilm infections <i>Staphylococcus aureus</i> therapeutic antibiofilm |
| url | https://www.mdpi.com/2079-6382/12/1/87 |
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