Cathepsin B Is the Driving Force of Esophageal Cell Invasion in a Fibroblast-Dependent Manner

Cathepsin B Is the Driving Force of Esophageal Cell Invasion in a Fibroblast-Dependent Manner

Esophageal cancer, which frequently exhibits coordinated loss of E-cadherin (Ecad) and transforming growth factor β (TGFβ) receptor II (TβRII), has a high mortality rate. In a three-dimensional organotypic culture model system, esophageal keratinocytes expressing dominant-negative mutant versions of...

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Bibliographic Details
Main Authors: Claudia D. Andl, Kelsey M. McCowan, Gillian L. Allison, Anil K. Rustgi
Format: Article
Language:English
Published: Elsevier 2010-06-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558610800065

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