Cofactor-independent phosphoglycerate mutase from nematodes has limited druggability, as revealed by two high-throughput screens.

Cofactor-independent phosphoglycerate mutase from nematodes has limited druggability, as revealed by two high-throughput screens.

Cofactor-independent phosphoglycerate mutase (iPGAM) is essential for the growth of C. elegans but is absent from humans, suggesting its potential as a drug target in parasitic nematodes such as Brugia malayi, a cause of lymphatic filariasis (LF). iPGAM's active site is small and hydrophilic, i...

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Main Authors: Gregory J Crowther, Michael L Booker, Min He, Ting Li, Sylvine Raverdy, Jacopo F Novelli, Panqing He, Natalie R G Dale, Amy M Fife, Robert H Barker, Martin L Kramer, Wesley C Van Voorhis, Clotilde K S Carlow, Ming-Wei Wang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS Neglected Tropical Diseases
Online Access:http://europepmc.org/articles/PMC3886921?pdf=render

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