A Sensitive Yellow Fever Virus Entry Reporter Identifies Valosin-Containing Protein (VCP/p97) as an Essential Host Factor for Flavivirus Uncoating

A Sensitive Yellow Fever Virus Entry Reporter Identifies Valosin-Containing Protein (VCP/p97) as an Essential Host Factor for Flavivirus Uncoating

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Flaviviruses are enveloped, arthropod-borne, positive-strand RNA viruses that cause significant human disease. While the basic mechanisms of flavivirus entry and fusion are understood, little is known about the postfusion events that precede RNA replication, such as nucleocapsid disassembly. We rece...

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Bibliographic Details
Main Authors: Shuo Zhang, Harish N. Ramanathan, Florian Douam, Katrina B. Mar, Jinhong Chang, Priscilla L. Yang, John W. Schoggins, Alexander Ploss, Brett D. Lindenbach
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Proceedings
Subjects:
flavivirus
nucleocapsid
uncoating
viral entry
ubiquitin
VCP/p97
Online Access:https://www.mdpi.com/2504-3900/50/1/147

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