Molecular interactions of an alkaloid euchrestifoline as a new acetylcholinesterase inhibitor
Acetylcholinesterase (AChE) inhibitors are well established therapeutic agents for clinical management of Alzheimer's Diseases and other disorders associated with deficient cholinergic neurotransmission. In the current investigation, a new inhibitor has been reported for its significant AChE in...
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| Format: | Article |
| Language: | English |
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Bangladesh Pharmacological Society
2013-10-01
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| Series: | Bangladesh Journal of Pharmacology |
| Subjects: | |
| Online Access: | https://www.banglajol.info/index.php/BJP/article/view/16417 |
| _version_ | 1828809856520290304 |
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| author | Fazal Ur Rehman Muhammad Faird Khan Inamullah Khan - Roohullah |
| author_facet | Fazal Ur Rehman Muhammad Faird Khan Inamullah Khan - Roohullah |
| author_sort | Fazal Ur Rehman |
| collection | DOAJ |
| description | Acetylcholinesterase (AChE) inhibitors are well established therapeutic agents for clinical management of Alzheimer's Diseases and other disorders associated with deficient cholinergic neurotransmission. In the current investigation, a new inhibitor has been reported for its significant AChE inhibitory. euchrestifoline was isolated from the extract of Murraya paniculata. Isolated compound showed significant enzyme inhibitory activity (IC50 value: 93.1 ± 0.0 ?M). Molecular docking revealed structural insights behind its significant inhibitory activity. Various molecular interaction were found between euchrestifoline and Ache especially Ser122, Trp84 and Tyr121. This study indicated promising potential of euchrestifoline to be further developed and explored as potential lead compound. |
| first_indexed | 2024-12-12T09:02:49Z |
| format | Article |
| id | doaj.art-984d760b62fb4b57a753fb23c17d7f9c |
| institution | Directory Open Access Journal |
| issn | 1991-0088 |
| language | English |
| last_indexed | 2024-12-12T09:02:49Z |
| publishDate | 2013-10-01 |
| publisher | Bangladesh Pharmacological Society |
| record_format | Article |
| series | Bangladesh Journal of Pharmacology |
| spelling | doaj.art-984d760b62fb4b57a753fb23c17d7f9c2022-12-22T00:29:47ZengBangladesh Pharmacological SocietyBangladesh Journal of Pharmacology1991-00882013-10-018410.3329/bjp.v8i4.16417Molecular interactions of an alkaloid euchrestifoline as a new acetylcholinesterase inhibitorFazal Ur Rehman0Muhammad Faird Khan1Inamullah Khan2- Roohullah3Faculty of Pharmacy Gomal University, Dera Ismail Khan, KPKFaculty of Pharmacy Gomal University, Dera Ismail Khan, KPKDepartment of Pharmacy, University of Peshawar, PeshawarDepartment of Pharmacy, University of Abasyn, PeshawarAcetylcholinesterase (AChE) inhibitors are well established therapeutic agents for clinical management of Alzheimer's Diseases and other disorders associated with deficient cholinergic neurotransmission. In the current investigation, a new inhibitor has been reported for its significant AChE inhibitory. euchrestifoline was isolated from the extract of Murraya paniculata. Isolated compound showed significant enzyme inhibitory activity (IC50 value: 93.1 ± 0.0 ?M). Molecular docking revealed structural insights behind its significant inhibitory activity. Various molecular interaction were found between euchrestifoline and Ache especially Ser122, Trp84 and Tyr121. This study indicated promising potential of euchrestifoline to be further developed and explored as potential lead compound.https://www.banglajol.info/index.php/BJP/article/view/16417AcetylcholinestearseDockingEuchrestifoline |
| spellingShingle | Fazal Ur Rehman Muhammad Faird Khan Inamullah Khan - Roohullah Molecular interactions of an alkaloid euchrestifoline as a new acetylcholinesterase inhibitor Bangladesh Journal of Pharmacology Acetylcholinestearse Docking Euchrestifoline |
| title | Molecular interactions of an alkaloid euchrestifoline as a new acetylcholinesterase inhibitor |
| title_full | Molecular interactions of an alkaloid euchrestifoline as a new acetylcholinesterase inhibitor |
| title_fullStr | Molecular interactions of an alkaloid euchrestifoline as a new acetylcholinesterase inhibitor |
| title_full_unstemmed | Molecular interactions of an alkaloid euchrestifoline as a new acetylcholinesterase inhibitor |
| title_short | Molecular interactions of an alkaloid euchrestifoline as a new acetylcholinesterase inhibitor |
| title_sort | molecular interactions of an alkaloid euchrestifoline as a new acetylcholinesterase inhibitor |
| topic | Acetylcholinestearse Docking Euchrestifoline |
| url | https://www.banglajol.info/index.php/BJP/article/view/16417 |
| work_keys_str_mv | AT fazalurrehman molecularinteractionsofanalkaloideuchrestifolineasanewacetylcholinesteraseinhibitor AT muhammadfairdkhan molecularinteractionsofanalkaloideuchrestifolineasanewacetylcholinesteraseinhibitor AT inamullahkhan molecularinteractionsofanalkaloideuchrestifolineasanewacetylcholinesteraseinhibitor AT roohullah molecularinteractionsofanalkaloideuchrestifolineasanewacetylcholinesteraseinhibitor |