Delivery room intubation and severe intraventricular hemorrhage in extremely preterm infants without low Apgar scores: A Japanese retrospective cohort study
Abstract The purpose of this study was to assess the associations between delivery room intubation (DRI) and severe intraventricular hemorrhage (IVH), as well as other neonatal outcomes, among extremely preterm infants without low Apgar scores using data from a large-scale neonatal registry data in...
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Nature Portfolio
2023-09-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-41010-x |
| _version_ | 1797453076247871488 |
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| author | Kei Tamai Naomi Matsumoto Takashi Yorifuji Akihito Takeuchi Makoto Nakamura Kazue Nakamura Misao Kageyama The Neonatal Research Network of Japan |
| author_facet | Kei Tamai Naomi Matsumoto Takashi Yorifuji Akihito Takeuchi Makoto Nakamura Kazue Nakamura Misao Kageyama The Neonatal Research Network of Japan |
| author_sort | Kei Tamai |
| collection | DOAJ |
| description | Abstract The purpose of this study was to assess the associations between delivery room intubation (DRI) and severe intraventricular hemorrhage (IVH), as well as other neonatal outcomes, among extremely preterm infants without low Apgar scores using data from a large-scale neonatal registry data in Japan. We analyzed data for infants born at 24–27 gestational weeks between 2003 and 2019 in Japan using robust Poisson regression. Infants with low Apgar scores (≤ 1 at 1 min or ≤ 3 at 5 min) were excluded. The primary outcome was severe IVH. Secondary outcomes were other neonatal morbidities and mortality. The full cohort included 16,081 infants (intubation cohort, 13,367; no intubation cohort, 2714). The rate of DRI increased over time (78.6%, 2003–2008; 83.4%, 2009–2014; 87.8%, 2015–2019), while the rate of severe IVH decreased (7.1%, 2003–2008; 5.7%, 2009–2014; 5.3%, 2015–2019). Infants with DRI had a higher risk of severe IVH than those without DRI (6.8% vs. 2.3%; adjusted risk ratio, 1.86; 95% confidence interval, 1.33–2.58). The results did not change substantially when stratified by gestational age. Despite conflicting changes over time in DRI and severe IVH, DRI was associated with an increased risk of severe IVH among extremely preterm infants in Japan. |
| first_indexed | 2024-03-09T15:17:43Z |
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| id | doaj.art-984e3ef01048424a94aec9567f22fe79 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-09T15:17:43Z |
| publishDate | 2023-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-984e3ef01048424a94aec9567f22fe792023-11-26T13:01:05ZengNature PortfolioScientific Reports2045-23222023-09-011311910.1038/s41598-023-41010-xDelivery room intubation and severe intraventricular hemorrhage in extremely preterm infants without low Apgar scores: A Japanese retrospective cohort studyKei Tamai0Naomi Matsumoto1Takashi Yorifuji2Akihito Takeuchi3Makoto Nakamura4Kazue Nakamura5Misao Kageyama6The Neonatal Research Network of JapanDivision of Neonatology, Okayama Medical Center, National Hospital OrganizationDepartment of Epidemiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical SciencesDepartment of Epidemiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical SciencesDivision of Neonatology, Okayama Medical Center, National Hospital OrganizationDivision of Neonatology, Okayama Medical Center, National Hospital OrganizationDivision of Neonatology, Okayama Medical Center, National Hospital OrganizationDivision of Neonatology, Okayama Medical Center, National Hospital OrganizationAbstract The purpose of this study was to assess the associations between delivery room intubation (DRI) and severe intraventricular hemorrhage (IVH), as well as other neonatal outcomes, among extremely preterm infants without low Apgar scores using data from a large-scale neonatal registry data in Japan. We analyzed data for infants born at 24–27 gestational weeks between 2003 and 2019 in Japan using robust Poisson regression. Infants with low Apgar scores (≤ 1 at 1 min or ≤ 3 at 5 min) were excluded. The primary outcome was severe IVH. Secondary outcomes were other neonatal morbidities and mortality. The full cohort included 16,081 infants (intubation cohort, 13,367; no intubation cohort, 2714). The rate of DRI increased over time (78.6%, 2003–2008; 83.4%, 2009–2014; 87.8%, 2015–2019), while the rate of severe IVH decreased (7.1%, 2003–2008; 5.7%, 2009–2014; 5.3%, 2015–2019). Infants with DRI had a higher risk of severe IVH than those without DRI (6.8% vs. 2.3%; adjusted risk ratio, 1.86; 95% confidence interval, 1.33–2.58). The results did not change substantially when stratified by gestational age. Despite conflicting changes over time in DRI and severe IVH, DRI was associated with an increased risk of severe IVH among extremely preterm infants in Japan.https://doi.org/10.1038/s41598-023-41010-x |
| spellingShingle | Kei Tamai Naomi Matsumoto Takashi Yorifuji Akihito Takeuchi Makoto Nakamura Kazue Nakamura Misao Kageyama The Neonatal Research Network of Japan Delivery room intubation and severe intraventricular hemorrhage in extremely preterm infants without low Apgar scores: A Japanese retrospective cohort study Scientific Reports |
| title | Delivery room intubation and severe intraventricular hemorrhage in extremely preterm infants without low Apgar scores: A Japanese retrospective cohort study |
| title_full | Delivery room intubation and severe intraventricular hemorrhage in extremely preterm infants without low Apgar scores: A Japanese retrospective cohort study |
| title_fullStr | Delivery room intubation and severe intraventricular hemorrhage in extremely preterm infants without low Apgar scores: A Japanese retrospective cohort study |
| title_full_unstemmed | Delivery room intubation and severe intraventricular hemorrhage in extremely preterm infants without low Apgar scores: A Japanese retrospective cohort study |
| title_short | Delivery room intubation and severe intraventricular hemorrhage in extremely preterm infants without low Apgar scores: A Japanese retrospective cohort study |
| title_sort | delivery room intubation and severe intraventricular hemorrhage in extremely preterm infants without low apgar scores a japanese retrospective cohort study |
| url | https://doi.org/10.1038/s41598-023-41010-x |
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