Phytochemical and pharmacological profiling of Trewia nudiflora Linn. leaf extract deciphers therapeutic potentials against thrombosis, arthritis, helminths, and insects
The objective of the current study was to examine the phytochemical and in vitro thrombolytic, anti-arthritic, anthelmintic, and insecticidal effects of Trewia nudiflora (TN) methanolic leaf extract with its methanol (MTN), chloroform (CTN), and ethyl acetate (ETN) fractions. Pheretima posthuma and...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
De Gruyter
2022-11-01
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| Series: | Open Chemistry |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/chem-2022-0244 |
| _version_ | 1811320207883370496 |
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| author | Ripa Farhana Alam Hossain Md. Jamal Munira Mst Shirajum Roy Arpita Riya Fahmida Haque Alam Fowzia Feda Farjeen Binte Taslim Umiya Nesa Mst. Luthfun Rashid Mohammad A. Alghamdi Saad Almehmadi Mazen Abdulaziz Osama Alsaidi Abrar Khidir Elshiekh Babiker |
| author_facet | Ripa Farhana Alam Hossain Md. Jamal Munira Mst Shirajum Roy Arpita Riya Fahmida Haque Alam Fowzia Feda Farjeen Binte Taslim Umiya Nesa Mst. Luthfun Rashid Mohammad A. Alghamdi Saad Almehmadi Mazen Abdulaziz Osama Alsaidi Abrar Khidir Elshiekh Babiker |
| author_sort | Ripa Farhana Alam |
| collection | DOAJ |
| description | The objective of the current study was to examine the phytochemical and in vitro thrombolytic, anti-arthritic, anthelmintic, and insecticidal effects of Trewia nudiflora (TN) methanolic leaf extract with its methanol (MTN), chloroform (CTN), and ethyl acetate (ETN) fractions. Pheretima posthuma and Tribolium castaneum were employed for evaluating the antihelmintic and insecticidal properties, respectively. All the tested extracts showed the presence of copious potential constituents in phytochemical analysis. Among all extracts, MTN extract exhibited the utmost clot lysis (35.95 ± 4.81%) property compared to standard streptokinase (SK) (53.77 ± 7.52%). All samples displayed striking protein denaturation activity in a dose-dependent manner (100–500 µg/mL), where the highest inhibition was observed for MTN (67.26 ± 6.39% at 500 µg/mL). Each extract demonstrated considerable anthelmintic activity at 25–75 mg/mL dose ranges. ETN showed the strongest anthelmintic activity at the highest dose. Among all samples, the CTN extract displayed the utmost mortality rate (77.22%) in the insecticidal test. The results of the study suggest that T. nudiflora leaf extracts may have potential against thrombosis, arthritis, helminths, and insects, which warrants the necessity of extensive isolation and identification of bioactive compounds to develop newer effective drugs upon preclinical and clinical investigations. |
| first_indexed | 2024-04-13T12:55:01Z |
| format | Article |
| id | doaj.art-984f5453c7ba40fab048ed1f6aaeada7 |
| institution | Directory Open Access Journal |
| issn | 2391-5420 |
| language | English |
| last_indexed | 2024-04-13T12:55:01Z |
| publishDate | 2022-11-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Open Chemistry |
| spelling | doaj.art-984f5453c7ba40fab048ed1f6aaeada72022-12-22T02:46:05ZengDe GruyterOpen Chemistry2391-54202022-11-012011304131210.1515/chem-2022-0244Phytochemical and pharmacological profiling of Trewia nudiflora Linn. leaf extract deciphers therapeutic potentials against thrombosis, arthritis, helminths, and insectsRipa Farhana Alam0Hossain Md. Jamal1Munira Mst Shirajum2Roy Arpita3Riya Fahmida Haque4Alam Fowzia5Feda Farjeen Binte6Taslim Umiya7Nesa Mst. Luthfun8Rashid Mohammad A.9Alghamdi Saad10Almehmadi Mazen11Abdulaziz Osama12Alsaidi Abrar13Khidir Elshiekh Babiker14School of Pharmacy, Brac University, 41-Pacific Tower, Mohakhali, Dhaka-1212, BangladeshDepartment of Pharmacy, State University of Bangladesh, 77 Satmasjid Road, Dhanmondi, Dhaka-1205, BangladeshDepartment of Pharmacy, Southeast University, Banani, Dhaka 1213, BangladeshDepartment of Biotechnology, School of Engineering & Technology, Sharda University, Greater Noida, IndiaSchool of Pharmacy, Brac University, 41-Pacific Tower, Mohakhali, Dhaka-1212, BangladeshSchool of Pharmacy, Brac University, 41-Pacific Tower, Mohakhali, Dhaka-1212, BangladeshSchool of Pharmacy, Brac University, 41-Pacific Tower, Mohakhali, Dhaka-1212, BangladeshSchool of Pharmacy, Brac University, 41-Pacific Tower, Mohakhali, Dhaka-1212, BangladeshDepartment of Pharmacy, State University of Bangladesh, 77 Satmasjid Road, Dhanmondi, Dhaka-1205, BangladeshDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka-1000, BangladeshLaboratory Medicine Department, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, Saudi ArabiaClinical Laboratories Science Department, College of Applied Medical Science, Taif University, Saudi ArabiaClinical Laboratories Science Department, College of Applied Medical Science, Taif University, Saudi ArabiaRegional Laboratory, Jeddah, Saudi ArabiaLaboratory Medicine Department, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, Saudi ArabiaThe objective of the current study was to examine the phytochemical and in vitro thrombolytic, anti-arthritic, anthelmintic, and insecticidal effects of Trewia nudiflora (TN) methanolic leaf extract with its methanol (MTN), chloroform (CTN), and ethyl acetate (ETN) fractions. Pheretima posthuma and Tribolium castaneum were employed for evaluating the antihelmintic and insecticidal properties, respectively. All the tested extracts showed the presence of copious potential constituents in phytochemical analysis. Among all extracts, MTN extract exhibited the utmost clot lysis (35.95 ± 4.81%) property compared to standard streptokinase (SK) (53.77 ± 7.52%). All samples displayed striking protein denaturation activity in a dose-dependent manner (100–500 µg/mL), where the highest inhibition was observed for MTN (67.26 ± 6.39% at 500 µg/mL). Each extract demonstrated considerable anthelmintic activity at 25–75 mg/mL dose ranges. ETN showed the strongest anthelmintic activity at the highest dose. Among all samples, the CTN extract displayed the utmost mortality rate (77.22%) in the insecticidal test. The results of the study suggest that T. nudiflora leaf extracts may have potential against thrombosis, arthritis, helminths, and insects, which warrants the necessity of extensive isolation and identification of bioactive compounds to develop newer effective drugs upon preclinical and clinical investigations.https://doi.org/10.1515/chem-2022-0244trewia nudiflorathrombolyticanti-arthriticanthelminticinsecticidal activity |
| spellingShingle | Ripa Farhana Alam Hossain Md. Jamal Munira Mst Shirajum Roy Arpita Riya Fahmida Haque Alam Fowzia Feda Farjeen Binte Taslim Umiya Nesa Mst. Luthfun Rashid Mohammad A. Alghamdi Saad Almehmadi Mazen Abdulaziz Osama Alsaidi Abrar Khidir Elshiekh Babiker Phytochemical and pharmacological profiling of Trewia nudiflora Linn. leaf extract deciphers therapeutic potentials against thrombosis, arthritis, helminths, and insects Open Chemistry trewia nudiflora thrombolytic anti-arthritic anthelmintic insecticidal activity |
| title | Phytochemical and pharmacological profiling of Trewia nudiflora Linn. leaf extract deciphers therapeutic potentials against thrombosis, arthritis, helminths, and insects |
| title_full | Phytochemical and pharmacological profiling of Trewia nudiflora Linn. leaf extract deciphers therapeutic potentials against thrombosis, arthritis, helminths, and insects |
| title_fullStr | Phytochemical and pharmacological profiling of Trewia nudiflora Linn. leaf extract deciphers therapeutic potentials against thrombosis, arthritis, helminths, and insects |
| title_full_unstemmed | Phytochemical and pharmacological profiling of Trewia nudiflora Linn. leaf extract deciphers therapeutic potentials against thrombosis, arthritis, helminths, and insects |
| title_short | Phytochemical and pharmacological profiling of Trewia nudiflora Linn. leaf extract deciphers therapeutic potentials against thrombosis, arthritis, helminths, and insects |
| title_sort | phytochemical and pharmacological profiling of trewia nudiflora linn leaf extract deciphers therapeutic potentials against thrombosis arthritis helminths and insects |
| topic | trewia nudiflora thrombolytic anti-arthritic anthelmintic insecticidal activity |
| url | https://doi.org/10.1515/chem-2022-0244 |
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