Are changes in olanzapine-induced liver enzyme levels associated with GSTT1, GSTM1, GSTP1, and OGG1 gene polymorphisms?
Olanzapine treatment sometimes produces transient liver biochemistry abnormalities, and such drug-induced liver injuries are mainly monitored by measuring blood levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST), whereas alpha-glutathione-S-transferase (α-GST) is not routi...
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| Format: | Article |
| Language: | English |
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Sciendo
2024-03-01
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| Series: | Arhiv za Higijenu Rada i Toksikologiju |
| Subjects: | |
| Online Access: | https://doi.org/10.2478/aiht-2024-75-3770 |
| _version_ | 1797229597388963840 |
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| author | Elkama Aylin İlik Nazlıcan Ak Mehmet Karahalil Bensu |
| author_facet | Elkama Aylin İlik Nazlıcan Ak Mehmet Karahalil Bensu |
| author_sort | Elkama Aylin |
| collection | DOAJ |
| description | Olanzapine treatment sometimes produces transient liver biochemistry abnormalities, and such drug-induced liver injuries are mainly monitored by measuring blood levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST), whereas alpha-glutathione-S-transferase (α-GST) is not routinely measured in clinics, even though it can serve as an earlier and more specific biomarker of liver damage. Susceptibility to drug-induced liver injury can much depend on the gene polymorphisms regulating the activity of DNA detoxification and repair enzymes. The aim of this study was to evaluate which of the three liver enzymes – α-GST, ALT, and AST – is the most sensitive biomarker of olanzapine-induced liver injury and how their blood levels are affected by the GSTT1, GSTM1, GSTP1, and OGG1 gene polymorphisms in 30 olanzapine-treated patients. Contrary to our hypothesis, the increase in serum α-GST levels was not significantly greater than that of the transaminases. ALT turned out to be an earlier biomarker of liver injury than the other two enzymes. No significant association was found between gene polymorphisms and liver enzyme levels, save for GSTP1 Ile/Val + Val/Val and ALT, which points to this genotype as a risk factor for drug-induced liver injury. Future studies might help to identify the underlying mechanisms of transient liver enzyme increase associated with this genotype. |
| first_indexed | 2024-04-24T15:15:07Z |
| format | Article |
| id | doaj.art-98524015860c448099de182242aa8b25 |
| institution | Directory Open Access Journal |
| issn | 1848-6312 |
| language | English |
| last_indexed | 2024-04-24T15:15:07Z |
| publishDate | 2024-03-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Arhiv za Higijenu Rada i Toksikologiju |
| spelling | doaj.art-98524015860c448099de182242aa8b252024-04-02T09:28:46ZengSciendoArhiv za Higijenu Rada i Toksikologiju1848-63122024-03-01751616710.2478/aiht-2024-75-3770Are changes in olanzapine-induced liver enzyme levels associated with GSTT1, GSTM1, GSTP1, and OGG1 gene polymorphisms?Elkama Aylin0İlik Nazlıcan1Ak Mehmet2Karahalil Bensu3Gazi University Faculty of Pharmacy, Department of Toxicology, Ankara, TurkeyGazi University Faculty of Pharmacy, Department of Toxicology, Ankara, TurkeyNecmettin Erbakan University, Meram Faculty of Medicine, Department of Psychiatry, Konya, TurkeyGazi University Faculty of Pharmacy, Department of Toxicology, Ankara, TurkeyOlanzapine treatment sometimes produces transient liver biochemistry abnormalities, and such drug-induced liver injuries are mainly monitored by measuring blood levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST), whereas alpha-glutathione-S-transferase (α-GST) is not routinely measured in clinics, even though it can serve as an earlier and more specific biomarker of liver damage. Susceptibility to drug-induced liver injury can much depend on the gene polymorphisms regulating the activity of DNA detoxification and repair enzymes. The aim of this study was to evaluate which of the three liver enzymes – α-GST, ALT, and AST – is the most sensitive biomarker of olanzapine-induced liver injury and how their blood levels are affected by the GSTT1, GSTM1, GSTP1, and OGG1 gene polymorphisms in 30 olanzapine-treated patients. Contrary to our hypothesis, the increase in serum α-GST levels was not significantly greater than that of the transaminases. ALT turned out to be an earlier biomarker of liver injury than the other two enzymes. No significant association was found between gene polymorphisms and liver enzyme levels, save for GSTP1 Ile/Val + Val/Val and ALT, which points to this genotype as a risk factor for drug-induced liver injury. Future studies might help to identify the underlying mechanisms of transient liver enzyme increase associated with this genotype.https://doi.org/10.2478/aiht-2024-75-3770α-gstaltastdrug-induced liver injurymental disorderspsychotropic drugsα-gstaltastmentalni poremećajilijekom prouzročeno oštećenje jetrepsihotropni lijekovi |
| spellingShingle | Elkama Aylin İlik Nazlıcan Ak Mehmet Karahalil Bensu Are changes in olanzapine-induced liver enzyme levels associated with GSTT1, GSTM1, GSTP1, and OGG1 gene polymorphisms? Arhiv za Higijenu Rada i Toksikologiju α-gst alt ast drug-induced liver injury mental disorders psychotropic drugs α-gst alt ast mentalni poremećaji lijekom prouzročeno oštećenje jetre psihotropni lijekovi |
| title | Are changes in olanzapine-induced liver enzyme levels associated with GSTT1, GSTM1, GSTP1, and OGG1 gene polymorphisms? |
| title_full | Are changes in olanzapine-induced liver enzyme levels associated with GSTT1, GSTM1, GSTP1, and OGG1 gene polymorphisms? |
| title_fullStr | Are changes in olanzapine-induced liver enzyme levels associated with GSTT1, GSTM1, GSTP1, and OGG1 gene polymorphisms? |
| title_full_unstemmed | Are changes in olanzapine-induced liver enzyme levels associated with GSTT1, GSTM1, GSTP1, and OGG1 gene polymorphisms? |
| title_short | Are changes in olanzapine-induced liver enzyme levels associated with GSTT1, GSTM1, GSTP1, and OGG1 gene polymorphisms? |
| title_sort | are changes in olanzapine induced liver enzyme levels associated with gstt1 gstm1 gstp1 and ogg1 gene polymorphisms |
| topic | α-gst alt ast drug-induced liver injury mental disorders psychotropic drugs α-gst alt ast mentalni poremećaji lijekom prouzročeno oštećenje jetre psihotropni lijekovi |
| url | https://doi.org/10.2478/aiht-2024-75-3770 |
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