Glucocorticoids: A review of its adverse effects including bone loss
Glucocorticoids (GCs) play a crucial role in the management of many inflammatory, immunological, and autoimmune diseases. Apart from symptomatic relief, they also act as disease-modifying agents as in arthritis and potent immunosuppressive agents as in vasculitides and systemic lupus erythematosus....
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2019-01-01
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| Series: | Indian Journal of Rheumatology |
| Subjects: | |
| Online Access: | http://www.indianjrheumatol.com/article.asp?issn=0973-3698;year=2019;volume=14;issue=5;spage=90;epage=98;aulast=Dua |
| _version_ | 1798045524368031744 |
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| author | Amit Dua Parthajit Das Vinod Ravindran |
| author_facet | Amit Dua Parthajit Das Vinod Ravindran |
| author_sort | Amit Dua |
| collection | DOAJ |
| description | Glucocorticoids (GCs) play a crucial role in the management of many inflammatory, immunological, and autoimmune diseases. Apart from symptomatic relief, they also act as disease-modifying agents as in arthritis and potent immunosuppressive agents as in vasculitides and systemic lupus erythematosus. However, they have been overused, misused, and abused because of their easy availability, low cost, and rapid action. On the other hand, they are also associated with a variety of adverse effects such as osteoporosis, increase risk of infections, cataract, glaucoma, myopathy, glucose intolerance, dyslipidemia, cardiovascular diseases, psychiatric disturbances, and adrenal suppression. GC-induced osteoporosis (GIOP) with increased fracture risk needs special mention, as it causes significant morbidity. In this review, we bring the readers up-to-date information with regard to the major adverse effects of systemic GCs with a special reference to prevention and management of GIOP. |
| first_indexed | 2024-04-11T23:22:23Z |
| format | Article |
| id | doaj.art-9852e1ff7da04b23834f0806a3521537 |
| institution | Directory Open Access Journal |
| issn | 0973-3698 0973-3701 |
| language | English |
| last_indexed | 2024-04-11T23:22:23Z |
| publishDate | 2019-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Rheumatology |
| spelling | doaj.art-9852e1ff7da04b23834f0806a35215372022-12-22T03:57:25ZengWolters Kluwer Medknow PublicationsIndian Journal of Rheumatology0973-36980973-37012019-01-01145909810.4103/0973-3698.272158Glucocorticoids: A review of its adverse effects including bone lossAmit DuaParthajit DasVinod RavindranGlucocorticoids (GCs) play a crucial role in the management of many inflammatory, immunological, and autoimmune diseases. Apart from symptomatic relief, they also act as disease-modifying agents as in arthritis and potent immunosuppressive agents as in vasculitides and systemic lupus erythematosus. However, they have been overused, misused, and abused because of their easy availability, low cost, and rapid action. On the other hand, they are also associated with a variety of adverse effects such as osteoporosis, increase risk of infections, cataract, glaucoma, myopathy, glucose intolerance, dyslipidemia, cardiovascular diseases, psychiatric disturbances, and adrenal suppression. GC-induced osteoporosis (GIOP) with increased fracture risk needs special mention, as it causes significant morbidity. In this review, we bring the readers up-to-date information with regard to the major adverse effects of systemic GCs with a special reference to prevention and management of GIOP.http://www.indianjrheumatol.com/article.asp?issn=0973-3698;year=2019;volume=14;issue=5;spage=90;epage=98;aulast=Duadenosumabglucocorticoid-inducedglucocorticoid-induced osteoporosisnewer steroidsosteoporosissteroids |
| spellingShingle | Amit Dua Parthajit Das Vinod Ravindran Glucocorticoids: A review of its adverse effects including bone loss Indian Journal of Rheumatology denosumab glucocorticoid-induced glucocorticoid-induced osteoporosis newer steroids osteoporosis steroids |
| title | Glucocorticoids: A review of its adverse effects including bone loss |
| title_full | Glucocorticoids: A review of its adverse effects including bone loss |
| title_fullStr | Glucocorticoids: A review of its adverse effects including bone loss |
| title_full_unstemmed | Glucocorticoids: A review of its adverse effects including bone loss |
| title_short | Glucocorticoids: A review of its adverse effects including bone loss |
| title_sort | glucocorticoids a review of its adverse effects including bone loss |
| topic | denosumab glucocorticoid-induced glucocorticoid-induced osteoporosis newer steroids osteoporosis steroids |
| url | http://www.indianjrheumatol.com/article.asp?issn=0973-3698;year=2019;volume=14;issue=5;spage=90;epage=98;aulast=Dua |
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