Association of total pre-existing comorbidities with stroke risk: a large-scale community-based cohort study from China
Abstract Background Comorbidities, any other coexisting diseases in patients with a particular index disease, are known to increase the mortality of a stroke. However, the association of pre-existing comorbidities with stroke risk has not been fully studied. Methods This study included 16,246 adults...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-10-01
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| Series: | BMC Public Health |
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| Online Access: | https://doi.org/10.1186/s12889-021-12002-1 |
| _version_ | 1819259995538063360 |
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| author | Ya Zhang Cuicui Wang Dong Liu Zhengyuan Zhou Shujun Gu Hui Zuo |
| author_facet | Ya Zhang Cuicui Wang Dong Liu Zhengyuan Zhou Shujun Gu Hui Zuo |
| author_sort | Ya Zhang |
| collection | DOAJ |
| description | Abstract Background Comorbidities, any other coexisting diseases in patients with a particular index disease, are known to increase the mortality of a stroke. However, the association of pre-existing comorbidities with stroke risk has not been fully studied. Methods This study included 16,246 adults from a prospective community-based cohort with a baseline survey conducted in 2013 in China. Participants were followed up with hospitalization records and the Cause of Death Registry. The association of eight pre-existing comorbidities (coronary heart disease, hyperlipidemia, hypertension, diabetes, previous stroke, chronic obstructive pulmonary disease, nephropathy, and cancer) with stroke risk was analyzed using the Cox proportional hazard model in 2020. Results At a median follow-up of 5.5 years, a total of 449 participants (206 men and 243 women) developed a stroke. Four pre-existing comorbidities (hypertension, congenital heart disease, previous stroke, and diabetes) were independently and positively associated with the risk for all types of stroke. The adjusted hazard ratios for participants with only 1 and ≥ 2 pre-existing comorbidities compared with those without pre-existing conditions were 1.96 (95% CI: 1.44, 2.67; P < 0.001) and 2.87 (95% CI; 2.09, 3.94; P < 0.001) for total stroke, respectively. Moreover, male and female participants with a combination of increased age and a higher number of pre-existing comorbidities experienced the greatest risk of stroke. Conclusions The number of pre-existing comorbidities was independently associated with an increased risk of stroke. There was a synergic effect between increased age and a higher number of pre-existing comorbidities on stroke occurrence. Our novel findings emphasize the importance and potential application of pre-existing comorbidities as a risk indicator in stroke prevention. |
| first_indexed | 2024-12-23T19:18:52Z |
| format | Article |
| id | doaj.art-98535decffd4461b936c76f40e80bdea |
| institution | Directory Open Access Journal |
| issn | 1471-2458 |
| language | English |
| last_indexed | 2024-12-23T19:18:52Z |
| publishDate | 2021-10-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Public Health |
| spelling | doaj.art-98535decffd4461b936c76f40e80bdea2022-12-21T17:34:15ZengBMCBMC Public Health1471-24582021-10-012111910.1186/s12889-021-12002-1Association of total pre-existing comorbidities with stroke risk: a large-scale community-based cohort study from ChinaYa Zhang0Cuicui Wang1Dong Liu2Zhengyuan Zhou3Shujun Gu4Hui Zuo5School of Public Health, Medical College of Soochow UniversitySchool of Public Health, Medical College of Soochow UniversitySchool of Public Health, Medical College of Soochow UniversityChangshu Center for Disease Control and PreventionChangshu Center for Disease Control and PreventionSchool of Public Health, Medical College of Soochow UniversityAbstract Background Comorbidities, any other coexisting diseases in patients with a particular index disease, are known to increase the mortality of a stroke. However, the association of pre-existing comorbidities with stroke risk has not been fully studied. Methods This study included 16,246 adults from a prospective community-based cohort with a baseline survey conducted in 2013 in China. Participants were followed up with hospitalization records and the Cause of Death Registry. The association of eight pre-existing comorbidities (coronary heart disease, hyperlipidemia, hypertension, diabetes, previous stroke, chronic obstructive pulmonary disease, nephropathy, and cancer) with stroke risk was analyzed using the Cox proportional hazard model in 2020. Results At a median follow-up of 5.5 years, a total of 449 participants (206 men and 243 women) developed a stroke. Four pre-existing comorbidities (hypertension, congenital heart disease, previous stroke, and diabetes) were independently and positively associated with the risk for all types of stroke. The adjusted hazard ratios for participants with only 1 and ≥ 2 pre-existing comorbidities compared with those without pre-existing conditions were 1.96 (95% CI: 1.44, 2.67; P < 0.001) and 2.87 (95% CI; 2.09, 3.94; P < 0.001) for total stroke, respectively. Moreover, male and female participants with a combination of increased age and a higher number of pre-existing comorbidities experienced the greatest risk of stroke. Conclusions The number of pre-existing comorbidities was independently associated with an increased risk of stroke. There was a synergic effect between increased age and a higher number of pre-existing comorbidities on stroke occurrence. Our novel findings emphasize the importance and potential application of pre-existing comorbidities as a risk indicator in stroke prevention.https://doi.org/10.1186/s12889-021-12002-1Pre-existing comorbidityStrokeRiskCohort studies |
| spellingShingle | Ya Zhang Cuicui Wang Dong Liu Zhengyuan Zhou Shujun Gu Hui Zuo Association of total pre-existing comorbidities with stroke risk: a large-scale community-based cohort study from China BMC Public Health Pre-existing comorbidity Stroke Risk Cohort studies |
| title | Association of total pre-existing comorbidities with stroke risk: a large-scale community-based cohort study from China |
| title_full | Association of total pre-existing comorbidities with stroke risk: a large-scale community-based cohort study from China |
| title_fullStr | Association of total pre-existing comorbidities with stroke risk: a large-scale community-based cohort study from China |
| title_full_unstemmed | Association of total pre-existing comorbidities with stroke risk: a large-scale community-based cohort study from China |
| title_short | Association of total pre-existing comorbidities with stroke risk: a large-scale community-based cohort study from China |
| title_sort | association of total pre existing comorbidities with stroke risk a large scale community based cohort study from china |
| topic | Pre-existing comorbidity Stroke Risk Cohort studies |
| url | https://doi.org/10.1186/s12889-021-12002-1 |
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