Dietary Selenium Regulates microRNAs in Metabolic Disease: Recent Progress
Selenium (Se) is an essential element for the maintenance of a healthy physiological state. However, due to environmental and dietary factors and the narrow safety range of Se, diseases caused by Se deficiency or excess have gained considerable traction in recent years. In particular, links have bee...
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| Format: | Article |
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MDPI AG
2021-05-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/13/5/1527 |
| _version_ | 1797535497840492544 |
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| author | Xin Huang Yu-Lan Dong Tong Li Wei Xiong Xu Zhang Peng-Jie Wang Jia-Qiang Huang |
| author_facet | Xin Huang Yu-Lan Dong Tong Li Wei Xiong Xu Zhang Peng-Jie Wang Jia-Qiang Huang |
| author_sort | Xin Huang |
| collection | DOAJ |
| description | Selenium (Se) is an essential element for the maintenance of a healthy physiological state. However, due to environmental and dietary factors and the narrow safety range of Se, diseases caused by Se deficiency or excess have gained considerable traction in recent years. In particular, links have been identified between low Se status, cognitive decline, immune disorders, and increased mortality, whereas excess Se increases metabolic risk. Considerable evidence has suggested microRNAs (miRNAs) regulate interactions between the environment (including the diet) and genes, and play important roles in several diseases, including cancer. MiRNAs target messenger RNAs to induce changes in proteins including selenoprotein expression, ultimately generating disease. While a plethora of data exists on the epigenetic regulation of other dietary factors, nutrient Se epigenetics and especially miRNA regulated mechanisms remain unclear. Thus, this review mainly focuses on Se metabolism, pathogenic mechanisms, and miRNAs as key regulatory factors in Se-related diseases. Finally, we attempt to clarify the regulatory mechanisms underpinning Se, miRNAs, selenoproteins, and Se-related diseases. |
| first_indexed | 2024-03-10T11:45:27Z |
| format | Article |
| id | doaj.art-9855185ae1bf4ef5b0c3fa40d786646d |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T11:45:27Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-9855185ae1bf4ef5b0c3fa40d786646d2023-11-21T18:06:20ZengMDPI AGNutrients2072-66432021-05-01135152710.3390/nu13051527Dietary Selenium Regulates microRNAs in Metabolic Disease: Recent ProgressXin Huang0Yu-Lan Dong1Tong Li2Wei Xiong3Xu Zhang4Peng-Jie Wang5Jia-Qiang Huang6Beijing Advanced Innovation Center for Food Nutrition and Human Health, Department of Nutrition and Health, China Agricultural University, Beijing 100083, ChinaBeijing Advanced Innovation Center for Food Nutrition and Human Health, Department of Nutrition and Health, China Agricultural University, Beijing 100083, ChinaBeijing Advanced Innovation Center for Food Nutrition and Human Health, Department of Nutrition and Health, China Agricultural University, Beijing 100083, ChinaBeijing Advanced Innovation Center for Food Nutrition and Human Health, Department of Nutrition and Health, China Agricultural University, Beijing 100083, ChinaBeijing Advanced Innovation Center for Food Nutrition and Human Health, Department of Nutrition and Health, China Agricultural University, Beijing 100083, ChinaBeijing Advanced Innovation Center for Food Nutrition and Human Health, Department of Nutrition and Health, China Agricultural University, Beijing 100083, ChinaBeijing Advanced Innovation Center for Food Nutrition and Human Health, Department of Nutrition and Health, China Agricultural University, Beijing 100083, ChinaSelenium (Se) is an essential element for the maintenance of a healthy physiological state. However, due to environmental and dietary factors and the narrow safety range of Se, diseases caused by Se deficiency or excess have gained considerable traction in recent years. In particular, links have been identified between low Se status, cognitive decline, immune disorders, and increased mortality, whereas excess Se increases metabolic risk. Considerable evidence has suggested microRNAs (miRNAs) regulate interactions between the environment (including the diet) and genes, and play important roles in several diseases, including cancer. MiRNAs target messenger RNAs to induce changes in proteins including selenoprotein expression, ultimately generating disease. While a plethora of data exists on the epigenetic regulation of other dietary factors, nutrient Se epigenetics and especially miRNA regulated mechanisms remain unclear. Thus, this review mainly focuses on Se metabolism, pathogenic mechanisms, and miRNAs as key regulatory factors in Se-related diseases. Finally, we attempt to clarify the regulatory mechanisms underpinning Se, miRNAs, selenoproteins, and Se-related diseases.https://www.mdpi.com/2072-6643/13/5/1527diseasesmetabolismmicroRNAseleniumselenoproteins |
| spellingShingle | Xin Huang Yu-Lan Dong Tong Li Wei Xiong Xu Zhang Peng-Jie Wang Jia-Qiang Huang Dietary Selenium Regulates microRNAs in Metabolic Disease: Recent Progress Nutrients diseases metabolism microRNA selenium selenoproteins |
| title | Dietary Selenium Regulates microRNAs in Metabolic Disease: Recent Progress |
| title_full | Dietary Selenium Regulates microRNAs in Metabolic Disease: Recent Progress |
| title_fullStr | Dietary Selenium Regulates microRNAs in Metabolic Disease: Recent Progress |
| title_full_unstemmed | Dietary Selenium Regulates microRNAs in Metabolic Disease: Recent Progress |
| title_short | Dietary Selenium Regulates microRNAs in Metabolic Disease: Recent Progress |
| title_sort | dietary selenium regulates micrornas in metabolic disease recent progress |
| topic | diseases metabolism microRNA selenium selenoproteins |
| url | https://www.mdpi.com/2072-6643/13/5/1527 |
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