Trimeric Small Interfering RNAs and Their Cholesterol-Containing Conjugates Exhibit Improved Accumulation in Tumors, but Dramatically Reduced Silencing Activity

Trimeric Small Interfering RNAs and Their Cholesterol-Containing Conjugates Exhibit Improved Accumulation in Tumors, but Dramatically Reduced Silencing Activity

Cholesterol derivatives of nuclease-resistant, anti-<i>MDR1</i> small-interfering RNAs were designed to contain a 2’-OMe-modified 21-bp siRNA and a 63-bp TsiRNA in order to investigate their accumulation and silencing activity in vitro and in vivo. The results showed that increasing the...

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Bibliographic Details
Main Authors: Ivan V. Chernikov, Daniil V. Gladkikh, Ulyana A. Karelina, Mariya I. Meschaninova, Alya G. Ven’yaminova, Valentin V. Vlassov, Elena L. Chernolovskaya
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Molecules
Subjects:
siRNA
TsiRNA
2’-O-methyl modifications
cholesterol conjugates
Dicer-substrate siRNA
<i>MDR1</i>
Online Access:https://www.mdpi.com/1420-3049/25/8/1877

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