Hippocampal Transcriptome-Wide Association Study Reveals Correlations Between Impaired Glutamatergic Synapse Pathway and Age-Related Hearing Loss in BXD-Recombinant Inbred Mice

Hippocampal Transcriptome-Wide Association Study Reveals Correlations Between Impaired Glutamatergic Synapse Pathway and Age-Related Hearing Loss in BXD-Recombinant Inbred Mice

Age-related hearing loss (ARHL) is associated with cognitive dysfunction; however, the detailed underlying mechanisms remain unclear. The aim of this study is to investigate the potential underlying mechanism with a system genetics approach. A transcriptome-wide association study was performed on ag...

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Bibliographic Details
Main Authors: Tingzhi Deng, Jingjing Li, Jian Liu, Fuyi Xu, Xiaoya Liu, Jia Mi, Jonas Bergquist, Helen Wang, Chunhua Yang, Lu Lu, Xicheng Song, Cuifang Yao, Geng Tian, Qing Yin Zheng
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Neuroscience
Subjects:
hearing loss
systems genetics
cognitive dysfunction
glutamine synthetase (Gls)
gene network
BXD mice strain
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2021.745668/full

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