Glass Transition Temperature of PLGA Particles and the Influence on Drug Delivery Applications
Over recent decades, poly(lactic-co-glycolic acid) (PLGA) based nano- and micro- drug delivery vehicles have been rapidly developed since PLGA was approved by the Food and Drug Administration (FDA). Common factors that influence PLGA particle properties have been extensively studied by researchers,...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-02-01
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| Series: | Polymers |
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| Online Access: | https://www.mdpi.com/2073-4360/14/5/993 |
| _version_ | 1797474028812763136 |
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| author | Guangliang Liu Kathleen McEnnis |
| author_facet | Guangliang Liu Kathleen McEnnis |
| author_sort | Guangliang Liu |
| collection | DOAJ |
| description | Over recent decades, poly(lactic-co-glycolic acid) (PLGA) based nano- and micro- drug delivery vehicles have been rapidly developed since PLGA was approved by the Food and Drug Administration (FDA). Common factors that influence PLGA particle properties have been extensively studied by researchers, such as particle size, polydispersity index (PDI), surface morphology, zeta potential, and drug loading efficiency. These properties have all been found to be key factors for determining the drug release kinetics of the drug delivery particles. For drug delivery applications the drug release behavior is a critical property, and PLGA drug delivery systems are still plagued with the issue of burst release when a large portion of the drug is suddenly released from the particle rather than the controlled release the particles are designed for. Other properties of the particles can play a role in the drug release behavior, such as the glass transition temperature (<i>T<sub>g</sub></i>). The <i>T<sub>g</sub></i>, however, is an underreported property of current PLGA based drug delivery systems. This review summarizes the basic knowledge of the glass transition temperature in PLGA particles, the factors that influence the <i>T<sub>g</sub></i>, the effect of <i>T<sub>g</sub></i> on drug release behavior, and presents the recent awareness of the influence of <i>T<sub>g</sub></i> on drug delivery applications. |
| first_indexed | 2024-03-09T20:24:26Z |
| format | Article |
| id | doaj.art-985b1af7566e4cbbbb54dd017060ebd6 |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-09T20:24:26Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-985b1af7566e4cbbbb54dd017060ebd62023-11-23T23:39:31ZengMDPI AGPolymers2073-43602022-02-0114599310.3390/polym14050993Glass Transition Temperature of PLGA Particles and the Influence on Drug Delivery ApplicationsGuangliang Liu0Kathleen McEnnis1Otto H. York Department of Chemical and Materials Engineering, New Jersey Institute of Technology, Newark, NJ 07102, USAOtto H. York Department of Chemical and Materials Engineering, New Jersey Institute of Technology, Newark, NJ 07102, USAOver recent decades, poly(lactic-co-glycolic acid) (PLGA) based nano- and micro- drug delivery vehicles have been rapidly developed since PLGA was approved by the Food and Drug Administration (FDA). Common factors that influence PLGA particle properties have been extensively studied by researchers, such as particle size, polydispersity index (PDI), surface morphology, zeta potential, and drug loading efficiency. These properties have all been found to be key factors for determining the drug release kinetics of the drug delivery particles. For drug delivery applications the drug release behavior is a critical property, and PLGA drug delivery systems are still plagued with the issue of burst release when a large portion of the drug is suddenly released from the particle rather than the controlled release the particles are designed for. Other properties of the particles can play a role in the drug release behavior, such as the glass transition temperature (<i>T<sub>g</sub></i>). The <i>T<sub>g</sub></i>, however, is an underreported property of current PLGA based drug delivery systems. This review summarizes the basic knowledge of the glass transition temperature in PLGA particles, the factors that influence the <i>T<sub>g</sub></i>, the effect of <i>T<sub>g</sub></i> on drug release behavior, and presents the recent awareness of the influence of <i>T<sub>g</sub></i> on drug delivery applications.https://www.mdpi.com/2073-4360/14/5/993glass transition temperaturePLGA copolymersdrug deliverynanoparticles |
| spellingShingle | Guangliang Liu Kathleen McEnnis Glass Transition Temperature of PLGA Particles and the Influence on Drug Delivery Applications Polymers glass transition temperature PLGA copolymers drug delivery nanoparticles |
| title | Glass Transition Temperature of PLGA Particles and the Influence on Drug Delivery Applications |
| title_full | Glass Transition Temperature of PLGA Particles and the Influence on Drug Delivery Applications |
| title_fullStr | Glass Transition Temperature of PLGA Particles and the Influence on Drug Delivery Applications |
| title_full_unstemmed | Glass Transition Temperature of PLGA Particles and the Influence on Drug Delivery Applications |
| title_short | Glass Transition Temperature of PLGA Particles and the Influence on Drug Delivery Applications |
| title_sort | glass transition temperature of plga particles and the influence on drug delivery applications |
| topic | glass transition temperature PLGA copolymers drug delivery nanoparticles |
| url | https://www.mdpi.com/2073-4360/14/5/993 |
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