Wheat Germ Agglutinin—From Toxicity to Biomedical Applications
Wheat germ agglutinin is a hevein class <i>N</i>-Acetylglucosamine–binding protein with specific toxicity and biomedical potential. It is extractable from wheat germ—a low-value byproduct of the wheat industry—using well–established extraction methods based on salt precipitation and affi...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-01-01
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| Series: | Applied Sciences |
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| Online Access: | https://www.mdpi.com/2076-3417/11/2/884 |
| _version_ | 1797409823986286592 |
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| author | Gabrielė Balčiūnaitė-Murzienė Mindaugas Dzikaras |
| author_facet | Gabrielė Balčiūnaitė-Murzienė Mindaugas Dzikaras |
| author_sort | Gabrielė Balčiūnaitė-Murzienė |
| collection | DOAJ |
| description | Wheat germ agglutinin is a hevein class <i>N</i>-Acetylglucosamine–binding protein with specific toxicity and biomedical potential. It is extractable from wheat germ—a low-value byproduct of the wheat industry—using well–established extraction methods based on salt precipitation and affinity chromatography. Due to its <i>N</i>-Acetylglucosamine affinity, wheat germ agglutinin exhibits antifungal properties as well as cytotoxic properties. Its anticancer properties have been demonstrated for various cancer cells, and toxicity mechanisms are well described. Wheat germ agglutinin has been demonstrated as a viable solution for various biomedical and therapeutic applications, such as chemotherapy, targeted drug delivery, antibiotic-resistant bacteria monitoring and elimination. This is performed mostly in conjunction with nanoparticles, liposomes, and other carrier mechanisms via surface functionalization. Combined with abundant wheat byproduct sources, wheat germ agglutinin has the potential to improve the biomedical field considerably. |
| first_indexed | 2024-03-09T04:20:13Z |
| format | Article |
| id | doaj.art-985d5884c58046a092ceba006ce78527 |
| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-03-09T04:20:13Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj.art-985d5884c58046a092ceba006ce785272023-12-03T13:48:50ZengMDPI AGApplied Sciences2076-34172021-01-0111288410.3390/app11020884Wheat Germ Agglutinin—From Toxicity to Biomedical ApplicationsGabrielė Balčiūnaitė-Murzienė0Mindaugas Dzikaras1Institute of Pharmaceutical Technologies, Faculty of Pharmacy, Academy of Medicine, Lithuanian University of Health Sciences, 44307 Kaunas, LithuaniaPanevėžys Institute of Technologies and Business, Kaunas University of Technology, 44249 Kaunas, LithuaniaWheat germ agglutinin is a hevein class <i>N</i>-Acetylglucosamine–binding protein with specific toxicity and biomedical potential. It is extractable from wheat germ—a low-value byproduct of the wheat industry—using well–established extraction methods based on salt precipitation and affinity chromatography. Due to its <i>N</i>-Acetylglucosamine affinity, wheat germ agglutinin exhibits antifungal properties as well as cytotoxic properties. Its anticancer properties have been demonstrated for various cancer cells, and toxicity mechanisms are well described. Wheat germ agglutinin has been demonstrated as a viable solution for various biomedical and therapeutic applications, such as chemotherapy, targeted drug delivery, antibiotic-resistant bacteria monitoring and elimination. This is performed mostly in conjunction with nanoparticles, liposomes, and other carrier mechanisms via surface functionalization. Combined with abundant wheat byproduct sources, wheat germ agglutinin has the potential to improve the biomedical field considerably.https://www.mdpi.com/2076-3417/11/2/884wheatgermwheat byproductsagglutininWGAtoxicity |
| spellingShingle | Gabrielė Balčiūnaitė-Murzienė Mindaugas Dzikaras Wheat Germ Agglutinin—From Toxicity to Biomedical Applications Applied Sciences wheat germ wheat byproducts agglutinin WGA toxicity |
| title | Wheat Germ Agglutinin—From Toxicity to Biomedical Applications |
| title_full | Wheat Germ Agglutinin—From Toxicity to Biomedical Applications |
| title_fullStr | Wheat Germ Agglutinin—From Toxicity to Biomedical Applications |
| title_full_unstemmed | Wheat Germ Agglutinin—From Toxicity to Biomedical Applications |
| title_short | Wheat Germ Agglutinin—From Toxicity to Biomedical Applications |
| title_sort | wheat germ agglutinin from toxicity to biomedical applications |
| topic | wheat germ wheat byproducts agglutinin WGA toxicity |
| url | https://www.mdpi.com/2076-3417/11/2/884 |
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