Clinicopathological Profile of Patients with Multiple Myeloma: An Ambispective Study
Introduction: Multiple Myeloma (MM) is a clonal expansion of B lineage plasma cells in bone marrow. MM accounts for 10-15% of haematological malignancies and 1% of all malignant diseases. Though, the aetiology of the disease is largely unknown, various factors have been found to increase the inciden...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2023-02-01
|
| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/17553/56417_CE[Ra1]_F(IS)_PF1(DA_SS)redo_PFA(SS)_PN(OM).pdf |
| _version_ | 1797869986674376704 |
|---|---|
| author | Aditi Gupta Kamal Malukani Garima Dhamnani Sushmita Tripathi Suvidhi Wankhade Avinash Raghuwanshi |
| author_facet | Aditi Gupta Kamal Malukani Garima Dhamnani Sushmita Tripathi Suvidhi Wankhade Avinash Raghuwanshi |
| author_sort | Aditi Gupta |
| collection | DOAJ |
| description | Introduction: Multiple Myeloma (MM) is a clonal expansion of B lineage plasma cells in bone marrow. MM accounts for 10-15% of haematological malignancies and 1% of all malignant diseases. Though, the aetiology of the disease is largely unknown, various factors have been found to increase the incidence of MM. The present comprehensive research work on MM in the Malwa region of central India is an attempt to establish on clinicodemographic, haematological, biochemical and radiological parameters and finally to stage them according to Durie Salmon Staging (DSS) system.
Aim: To study clinicopathological profile of patients with MM.
Materials and Methods: The present ambispective study was conducted on total 70 cases of MM reported in the Department of Pathology at Sri Aurobindo Medical College and Post Graduate Institute, Indore, Madhya Pradesh, India, from July 2012 to June 2020. The study design included retrospective studies from July 2012 to December 2018 (six years and five months) and prospective studies from November 2017 to April 2019 (one year and five months). The demographic data of patients’ including history and clinical findings were recorded. Complete Blood Count (CBC) was done in all cases. Biochemical investigations were also done. Urine samples of all patients were screened for the presence of Bence Jones protein. Biochemical parameters and staging of MM patients was done. Statistical analysis prepared in excels spreadsheet and quantitative data were presented as proportions.
Results: The study included a total of 70 cases of MM diagnosed on peripheral smear and/or bone marrow examination. The male:female ratio was 2.1:1, with a male preponderance. The results of the present study, reported 48 (68.57%) patients were male and 22 (31.43%) patients were females. In the present investigation, the authors diagnosed serum Lactate Dehydrogenase (LDH) levels were estimated in 63, out of 70 patients. Out of which, 25 (39.69%) patients had levels <240 U/L, while 23 (33%) and 17 (23.81%) patients had levels between 241-480 U/L and >480 U/L, respectively.
Conclusion: The present study, underlines the association between clinical presentation, laboratory parameters and radiological findings in establishing the diagnosis of MM. The present study emphasises not only the role of a bone marrow aspiration and biopsy in establishing a diagnosis of MM, but also, assessing the plasma cell burden in the marrow. |
| first_indexed | 2024-04-10T00:20:14Z |
| format | Article |
| id | doaj.art-985f528f54b542129cc040e90fc27bd0 |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-04-10T00:20:14Z |
| publishDate | 2023-02-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-985f528f54b542129cc040e90fc27bd02023-03-16T04:28:47ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2023-02-01172EC46EC5210.7860/JCDR/2023/56417.17553Clinicopathological Profile of Patients with Multiple Myeloma: An Ambispective StudyAditi Gupta0Kamal Malukani1Garima Dhamnani2Sushmita Tripathi3Suvidhi Wankhade4Avinash Raghuwanshi5Senior Resident, Department of Pathology, Sri Aurobindo Medical College and Post Graduate Institute, Indore, Madhya Pradesh, India.Senior Resident, Department of Pathology, Sri Aurobindo Medical College and Post Graduate Institute, Indore, Madhya Pradesh, India.Senior Resident, Department of Pathology, Sri Aurobindo Medical College and Post Graduate Institute, Indore, Madhya Pradesh, India.Junior Resident, Department of Pathology, Sri Aurobindo Medical College and Post Graduate Institute, Indore, Madhya Pradesh, India.Junior Resident, Department of Pathology, Sri Aurobindo Medical College and Post Graduate Institute, Indore, Madhya Pradesh, India.Junior Resident, Department of Pathology, Sri Aurobindo Medical College and Post Graduate Institute, Indore, Madhya Pradesh, India.Introduction: Multiple Myeloma (MM) is a clonal expansion of B lineage plasma cells in bone marrow. MM accounts for 10-15% of haematological malignancies and 1% of all malignant diseases. Though, the aetiology of the disease is largely unknown, various factors have been found to increase the incidence of MM. The present comprehensive research work on MM in the Malwa region of central India is an attempt to establish on clinicodemographic, haematological, biochemical and radiological parameters and finally to stage them according to Durie Salmon Staging (DSS) system. Aim: To study clinicopathological profile of patients with MM. Materials and Methods: The present ambispective study was conducted on total 70 cases of MM reported in the Department of Pathology at Sri Aurobindo Medical College and Post Graduate Institute, Indore, Madhya Pradesh, India, from July 2012 to June 2020. The study design included retrospective studies from July 2012 to December 2018 (six years and five months) and prospective studies from November 2017 to April 2019 (one year and five months). The demographic data of patients’ including history and clinical findings were recorded. Complete Blood Count (CBC) was done in all cases. Biochemical investigations were also done. Urine samples of all patients were screened for the presence of Bence Jones protein. Biochemical parameters and staging of MM patients was done. Statistical analysis prepared in excels spreadsheet and quantitative data were presented as proportions. Results: The study included a total of 70 cases of MM diagnosed on peripheral smear and/or bone marrow examination. The male:female ratio was 2.1:1, with a male preponderance. The results of the present study, reported 48 (68.57%) patients were male and 22 (31.43%) patients were females. In the present investigation, the authors diagnosed serum Lactate Dehydrogenase (LDH) levels were estimated in 63, out of 70 patients. Out of which, 25 (39.69%) patients had levels <240 U/L, while 23 (33%) and 17 (23.81%) patients had levels between 241-480 U/L and >480 U/L, respectively. Conclusion: The present study, underlines the association between clinical presentation, laboratory parameters and radiological findings in establishing the diagnosis of MM. The present study emphasises not only the role of a bone marrow aspiration and biopsy in establishing a diagnosis of MM, but also, assessing the plasma cell burden in the marrow.https://jcdr.net/articles/PDF/17553/56417_CE[Ra1]_F(IS)_PF1(DA_SS)redo_PFA(SS)_PN(OM).pdfanaemiainterleukin-6serum creatininetumour necrosis factor-alphavascular endothelial growth factor |
| spellingShingle | Aditi Gupta Kamal Malukani Garima Dhamnani Sushmita Tripathi Suvidhi Wankhade Avinash Raghuwanshi Clinicopathological Profile of Patients with Multiple Myeloma: An Ambispective Study Journal of Clinical and Diagnostic Research anaemia interleukin-6 serum creatinine tumour necrosis factor-alpha vascular endothelial growth factor |
| title | Clinicopathological Profile of Patients with Multiple Myeloma: An Ambispective Study |
| title_full | Clinicopathological Profile of Patients with Multiple Myeloma: An Ambispective Study |
| title_fullStr | Clinicopathological Profile of Patients with Multiple Myeloma: An Ambispective Study |
| title_full_unstemmed | Clinicopathological Profile of Patients with Multiple Myeloma: An Ambispective Study |
| title_short | Clinicopathological Profile of Patients with Multiple Myeloma: An Ambispective Study |
| title_sort | clinicopathological profile of patients with multiple myeloma an ambispective study |
| topic | anaemia interleukin-6 serum creatinine tumour necrosis factor-alpha vascular endothelial growth factor |
| url | https://jcdr.net/articles/PDF/17553/56417_CE[Ra1]_F(IS)_PF1(DA_SS)redo_PFA(SS)_PN(OM).pdf |
| work_keys_str_mv | AT aditigupta clinicopathologicalprofileofpatientswithmultiplemyelomaanambispectivestudy AT kamalmalukani clinicopathologicalprofileofpatientswithmultiplemyelomaanambispectivestudy AT garimadhamnani clinicopathologicalprofileofpatientswithmultiplemyelomaanambispectivestudy AT sushmitatripathi clinicopathologicalprofileofpatientswithmultiplemyelomaanambispectivestudy AT suvidhiwankhade clinicopathologicalprofileofpatientswithmultiplemyelomaanambispectivestudy AT avinashraghuwanshi clinicopathologicalprofileofpatientswithmultiplemyelomaanambispectivestudy |