Aerobic exercise regulates FGF21 and NLRP3 inflammasome-mediated pyroptosis and inhibits atherosclerosis in mice.

Aerobic exercise regulates FGF21 and NLRP3 inflammasome-mediated pyroptosis and inhibits atherosclerosis in mice.

Fibroblast growth factor 21 (FGF21), a known risk factor for atherosclerosis, is readily regulated by exercise, and it can inhibit NOD-like receptor protein 3 (NLRP3)-mediated pyroptosis. However, it is not clear whether aerobic exercise inhibits atherosclerosis via these pathways. Eight-week-old ap...

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Bibliographic Details
Main Authors: Xiao-Hong Li, Liang-Zhong Liu, Lin Chen, Qi-Ni Pan, Zi-Yao Ouyang, De-Jing Fan, Xiao Pan, Su-Yu Lu, Qiu-Hu Luo, Pin-Yue Tao, Hui-Qiao Huang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0273527

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