Correction of Experimental Retinal Ischemia by <span style="font-variant: small-caps">l</span>-Isomer of Ethylmethylhydroxypyridine Malate
An important task of pharmacology and ophtalmology is to find specific and highly effective agents for correcting retinal ischemia. The objective of this study is to increase the effectiveness of pharmacological correction of retinal ischemia by using new 3-hydroxypyridine derivative⁻<s...
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MDPI AG
2019-02-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/8/2/34 |
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| author | Anna Peresypkina Anton Pazhinsky Mikhail Pokrovskii Evgenya Beskhmelnitsyna Anna Pobeda Mikhail Korokin |
| author_facet | Anna Peresypkina Anton Pazhinsky Mikhail Pokrovskii Evgenya Beskhmelnitsyna Anna Pobeda Mikhail Korokin |
| author_sort | Anna Peresypkina |
| collection | DOAJ |
| description | An important task of pharmacology and ophtalmology is to find specific and highly effective agents for correcting retinal ischemia. The objective of this study is to increase the effectiveness of pharmacological correction of retinal ischemia by using new 3-hydroxypyridine derivative⁻<span style="font-variant: small-caps;">l</span>-isomer of ethylmethylhydroxypyridine malate. A modification to the retinal ischemia-reperfusion model was used, in which an increase in intraocular pressure is carried out by mechanical pressure (110 mmHg) to the front chamber of the eye for 30 min. The protective effects of <span style="font-variant: small-caps;">l</span>-isomer of ethylmethylhydroxypyridine malate in comparison with Emoxipine as pretreatment, with parabulbar injection, based on the model of retinal ischemia-reperfusion, were estimated by the changes in the ratio of the amplitudes of the a- and b-waves of electroretinography (the b/a coefficient) and ophthalmoscopy. The use of <span style="font-variant: small-caps;">l</span>-isomer of ethylmethylhydroxypyridine malate improves the retinal electrophysiological state after 72 h of reperfusion; in the group of rats treated with <span style="font-variant: small-caps;">l</span>-isomer of ethylmethylhydroxypyridine malate, the coefficient b/a was reliably increased by 9.5%, <i>p</i> < 0.05, in comparison with animals treated with Emoxipine, and by 91.7%, <i>p</i> < 0.05, in comparison with the group with no treatment. Furthermore, it prevents the development of ischemic changes in the retina observed in ophthalmoscopy to a greater extent than Emoxipine. |
| first_indexed | 2024-03-12T18:16:21Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-12T18:16:21Z |
| publishDate | 2019-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-986067e6b04a4c90ba83d67fa03801142023-08-02T09:08:55ZengMDPI AGAntioxidants2076-39212019-02-01823410.3390/antiox8020034antiox8020034Correction of Experimental Retinal Ischemia by <span style="font-variant: small-caps">l</span>-Isomer of Ethylmethylhydroxypyridine MalateAnna Peresypkina0Anton Pazhinsky1Mikhail Pokrovskii2Evgenya Beskhmelnitsyna3Anna Pobeda4Mikhail Korokin5Department of Pharmacology and Clinical Pharmacology, Institute of medicine, Belgorod State National Research University, Belgorod 308015, RussiaDepartment of Pharmacology and Clinical Pharmacology, Institute of medicine, Belgorod State National Research University, Belgorod 308015, RussiaDepartment of Pharmacology and Clinical Pharmacology, Institute of medicine, Belgorod State National Research University, Belgorod 308015, RussiaDepartment of Pharmacology and Clinical Pharmacology, Institute of medicine, Belgorod State National Research University, Belgorod 308015, RussiaDepartment of Pharmacology and Clinical Pharmacology, Institute of medicine, Belgorod State National Research University, Belgorod 308015, RussiaDepartment of Pharmacology and Clinical Pharmacology, Institute of medicine, Belgorod State National Research University, Belgorod 308015, RussiaAn important task of pharmacology and ophtalmology is to find specific and highly effective agents for correcting retinal ischemia. The objective of this study is to increase the effectiveness of pharmacological correction of retinal ischemia by using new 3-hydroxypyridine derivative⁻<span style="font-variant: small-caps;">l</span>-isomer of ethylmethylhydroxypyridine malate. A modification to the retinal ischemia-reperfusion model was used, in which an increase in intraocular pressure is carried out by mechanical pressure (110 mmHg) to the front chamber of the eye for 30 min. The protective effects of <span style="font-variant: small-caps;">l</span>-isomer of ethylmethylhydroxypyridine malate in comparison with Emoxipine as pretreatment, with parabulbar injection, based on the model of retinal ischemia-reperfusion, were estimated by the changes in the ratio of the amplitudes of the a- and b-waves of electroretinography (the b/a coefficient) and ophthalmoscopy. The use of <span style="font-variant: small-caps;">l</span>-isomer of ethylmethylhydroxypyridine malate improves the retinal electrophysiological state after 72 h of reperfusion; in the group of rats treated with <span style="font-variant: small-caps;">l</span>-isomer of ethylmethylhydroxypyridine malate, the coefficient b/a was reliably increased by 9.5%, <i>p</i> < 0.05, in comparison with animals treated with Emoxipine, and by 91.7%, <i>p</i> < 0.05, in comparison with the group with no treatment. Furthermore, it prevents the development of ischemic changes in the retina observed in ophthalmoscopy to a greater extent than Emoxipine.https://www.mdpi.com/2076-3921/8/2/34retinal ischemia<span style="font-variant: small-caps">l</span>-isomer of ethylmethylhydroxypyridine malateEmoxipineb/a coefficientWistar rats |
| spellingShingle | Anna Peresypkina Anton Pazhinsky Mikhail Pokrovskii Evgenya Beskhmelnitsyna Anna Pobeda Mikhail Korokin Correction of Experimental Retinal Ischemia by <span style="font-variant: small-caps">l</span>-Isomer of Ethylmethylhydroxypyridine Malate Antioxidants retinal ischemia <span style="font-variant: small-caps">l</span>-isomer of ethylmethylhydroxypyridine malate Emoxipine b/a coefficient Wistar rats |
| title | Correction of Experimental Retinal Ischemia by <span style="font-variant: small-caps">l</span>-Isomer of Ethylmethylhydroxypyridine Malate |
| title_full | Correction of Experimental Retinal Ischemia by <span style="font-variant: small-caps">l</span>-Isomer of Ethylmethylhydroxypyridine Malate |
| title_fullStr | Correction of Experimental Retinal Ischemia by <span style="font-variant: small-caps">l</span>-Isomer of Ethylmethylhydroxypyridine Malate |
| title_full_unstemmed | Correction of Experimental Retinal Ischemia by <span style="font-variant: small-caps">l</span>-Isomer of Ethylmethylhydroxypyridine Malate |
| title_short | Correction of Experimental Retinal Ischemia by <span style="font-variant: small-caps">l</span>-Isomer of Ethylmethylhydroxypyridine Malate |
| title_sort | correction of experimental retinal ischemia by span style font variant small caps l span isomer of ethylmethylhydroxypyridine malate |
| topic | retinal ischemia <span style="font-variant: small-caps">l</span>-isomer of ethylmethylhydroxypyridine malate Emoxipine b/a coefficient Wistar rats |
| url | https://www.mdpi.com/2076-3921/8/2/34 |
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