Serum Interleukin-34 in Psoriatic arthritis patients and its correlation with disease 1 activity, and subclinical atherosclerosis
Abstract Background Psoriatic arthritis (PsA) is a chronic multi-domains autoimmune inflammatory disorder. Patients with PsA have a significant prevalence of cardiovascular affection. Upregulated Interleukin-34 (IL-34) has been seen in many autoimmune disorders, and also in atherosclerotic plaques....
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| Format: | Article |
| Language: | English |
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SpringerOpen
2023-04-01
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| Series: | Egyptian Rheumatology and Rehabilitation |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s43166-023-00183-z |
| _version_ | 1797850044641050624 |
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| author | Samar Abdalhamed Tabra Mohammed Hassan Abu-Zaid Radwa Mahmoud Elsharaby Dina Maria Samah ElMiedany |
| author_facet | Samar Abdalhamed Tabra Mohammed Hassan Abu-Zaid Radwa Mahmoud Elsharaby Dina Maria Samah ElMiedany |
| author_sort | Samar Abdalhamed Tabra |
| collection | DOAJ |
| description | Abstract Background Psoriatic arthritis (PsA) is a chronic multi-domains autoimmune inflammatory disorder. Patients with PsA have a significant prevalence of cardiovascular affection. Upregulated Interleukin-34 (IL-34) has been seen in many autoimmune disorders, and also in atherosclerotic plaques. The aim of this observational case–control study was to evaluate the serum levels of il-34 in PsA patients and correlate between its level and disease activity, and subclinical cardiovascular affection. Results In this study, there were 70 PsA patients and 70 healthy volunteers, 43 patients were on Methotrexate, 6 on sulfasalazine, while 40 patients were on biological therapy either monotherapy or in combination with DMARDs. There were significant differences between PsA patients and controls in ESR, high sensitivity-CRP, total lipid profile, and IL-34 levels (p < 0.05) while there were no significant differences regarding Echo and ECG results. Also, we found that there was significant elevation in DAPSA score, hs-CRP, IL-34, and cIMT in the active patients when we compared them with inactive patients. IL-34 had significant positive correlations with DAPSA score, hs-CRP, and cIMT (r = 0.654, 0.579, and 0.658 respectively). Conclusion Serum interleukin-34 is an important marker in PsA as its levels were elevated in PsA patients and were correlated with disease activity and subclinical cardiovascular affection. |
| first_indexed | 2024-04-09T18:54:01Z |
| format | Article |
| id | doaj.art-986083f84f46427fabdfa0ef68b8f7ea |
| institution | Directory Open Access Journal |
| issn | 2090-3235 |
| language | English |
| last_indexed | 2024-04-09T18:54:01Z |
| publishDate | 2023-04-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Egyptian Rheumatology and Rehabilitation |
| spelling | doaj.art-986083f84f46427fabdfa0ef68b8f7ea2023-04-09T11:18:33ZengSpringerOpenEgyptian Rheumatology and Rehabilitation2090-32352023-04-015011810.1186/s43166-023-00183-zSerum Interleukin-34 in Psoriatic arthritis patients and its correlation with disease 1 activity, and subclinical atherosclerosisSamar Abdalhamed Tabra0Mohammed Hassan Abu-Zaid1Radwa Mahmoud Elsharaby2Dina Maria3Samah ElMiedany4Department of Rheumatology and Rehabilitation, Tanta UniversityDepartment of Rheumatology and Rehabilitation, Tanta UniversityDepartment of Clinical Pathology, Faculty of Medicine, Tanta UniversityDepartment of Cardiology, Faculty of Medicine, Tanta UniversityDepartment of Rheumatology and Rehabilitation, Tanta UniversityAbstract Background Psoriatic arthritis (PsA) is a chronic multi-domains autoimmune inflammatory disorder. Patients with PsA have a significant prevalence of cardiovascular affection. Upregulated Interleukin-34 (IL-34) has been seen in many autoimmune disorders, and also in atherosclerotic plaques. The aim of this observational case–control study was to evaluate the serum levels of il-34 in PsA patients and correlate between its level and disease activity, and subclinical cardiovascular affection. Results In this study, there were 70 PsA patients and 70 healthy volunteers, 43 patients were on Methotrexate, 6 on sulfasalazine, while 40 patients were on biological therapy either monotherapy or in combination with DMARDs. There were significant differences between PsA patients and controls in ESR, high sensitivity-CRP, total lipid profile, and IL-34 levels (p < 0.05) while there were no significant differences regarding Echo and ECG results. Also, we found that there was significant elevation in DAPSA score, hs-CRP, IL-34, and cIMT in the active patients when we compared them with inactive patients. IL-34 had significant positive correlations with DAPSA score, hs-CRP, and cIMT (r = 0.654, 0.579, and 0.658 respectively). Conclusion Serum interleukin-34 is an important marker in PsA as its levels were elevated in PsA patients and were correlated with disease activity and subclinical cardiovascular affection.https://doi.org/10.1186/s43166-023-00183-zPsoriatic arthritisIL-34Disease activitycIMTAtherosclerosisDAPSA score |
| spellingShingle | Samar Abdalhamed Tabra Mohammed Hassan Abu-Zaid Radwa Mahmoud Elsharaby Dina Maria Samah ElMiedany Serum Interleukin-34 in Psoriatic arthritis patients and its correlation with disease 1 activity, and subclinical atherosclerosis Egyptian Rheumatology and Rehabilitation Psoriatic arthritis IL-34 Disease activity cIMT Atherosclerosis DAPSA score |
| title | Serum Interleukin-34 in Psoriatic arthritis patients and its correlation with disease 1 activity, and subclinical atherosclerosis |
| title_full | Serum Interleukin-34 in Psoriatic arthritis patients and its correlation with disease 1 activity, and subclinical atherosclerosis |
| title_fullStr | Serum Interleukin-34 in Psoriatic arthritis patients and its correlation with disease 1 activity, and subclinical atherosclerosis |
| title_full_unstemmed | Serum Interleukin-34 in Psoriatic arthritis patients and its correlation with disease 1 activity, and subclinical atherosclerosis |
| title_short | Serum Interleukin-34 in Psoriatic arthritis patients and its correlation with disease 1 activity, and subclinical atherosclerosis |
| title_sort | serum interleukin 34 in psoriatic arthritis patients and its correlation with disease 1 activity and subclinical atherosclerosis |
| topic | Psoriatic arthritis IL-34 Disease activity cIMT Atherosclerosis DAPSA score |
| url | https://doi.org/10.1186/s43166-023-00183-z |
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