YAP Inactivation by Soft Mechanotransduction Relieves MAFG for Tumor Cell Dedifferentiation

YAP Inactivation by Soft Mechanotransduction Relieves MAFG for Tumor Cell Dedifferentiation

Solid tumor cells live in a highly dynamic mechanical microenvironment. How the extracellular-matrix-generated mechanotransduction regulates tumor cell development and differentiation remains an enigma. Here, we show that a low mechanical force generated from the soft matrix induces dedifferentiatio...

Full description

Bibliographic Details
Main Authors: Jiadi Lv, Xiaohan Liu, Yabo Zhou, Feiran Cheng, Haoran Chen, Shunshun Li, Dianheng Wang, Li Zhou, Zhenfeng Wang, Nannan Zhou, Jie Chen, Bo Huang
Format: Article
Language:English
Published: American Association for the Advancement of Science (AAAS) 2023-08-01
Series:Research
Online Access:https://spj.science.org/doi/10.34133/research.0215

Similar Items

Similar Items