A Facile Strategy for Visualizing and Modulating Droplet-Based Microfluidics
In droplet-based microfluidics, visualizing and modulating of droplets is often prerequisite. In this paper, we report a facile strategy for visualizing and modulating high-throughput droplets in microfluidics. In the strategy, by modulating the sampling frequency of a flash light with the droplet f...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-04-01
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| Series: | Micromachines |
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| Online Access: | https://www.mdpi.com/2072-666X/10/5/291 |
| _version_ | 1828869768416854016 |
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| author | Zehang Gao Huo Peng Minjie Zhu Lei Wu Chunping Jia Hongbo Zhou Jianlong Zhao |
| author_facet | Zehang Gao Huo Peng Minjie Zhu Lei Wu Chunping Jia Hongbo Zhou Jianlong Zhao |
| author_sort | Zehang Gao |
| collection | DOAJ |
| description | In droplet-based microfluidics, visualizing and modulating of droplets is often prerequisite. In this paper, we report a facile strategy for visualizing and modulating high-throughput droplets in microfluidics. In the strategy, by modulating the sampling frequency of a flash light with the droplet frequency, we are able to map a real high frequency signal to a low frequency signal, which facilitates visualizing and feedback controlling. Meanwhile, because of not needing synchronization signals, the strategy can be directly implemented on any droplet-based microfluidic chips. The only cost of the strategy is an additional signal generator. Moreover, the strategy can catch droplets with frequency up to several kilohertz, which covers the range of most high-throughput droplet-based microfluidics. In this paper, the principle, setup and procedure were introduced. Finally, as a demonstration, the strategy was also implemented in a miniaturized picoinjector in order to monitor and control the injection dosage to droplets. We expect that this facile strategy supplies a low-cost yet effective imaging system that can be easily implemented in miniaturized microfluidic systems or general laboratories. |
| first_indexed | 2024-12-13T05:57:13Z |
| format | Article |
| id | doaj.art-98637664cb334e6e8dec5e2c23e44014 |
| institution | Directory Open Access Journal |
| issn | 2072-666X |
| language | English |
| last_indexed | 2024-12-13T05:57:13Z |
| publishDate | 2019-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Micromachines |
| spelling | doaj.art-98637664cb334e6e8dec5e2c23e440142022-12-21T23:57:25ZengMDPI AGMicromachines2072-666X2019-04-0110529110.3390/mi10050291mi10050291A Facile Strategy for Visualizing and Modulating Droplet-Based MicrofluidicsZehang Gao0Huo Peng1Minjie Zhu2Lei Wu3Chunping Jia4Hongbo Zhou5Jianlong Zhao6State Key Laboratory of Transducer Technology, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai 200050, ChinaState Key Laboratory of Transducer Technology, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai 200050, ChinaState Key Laboratory of Transducer Technology, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai 200050, ChinaState Key Laboratory of Transducer Technology, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai 200050, ChinaState Key Laboratory of Transducer Technology, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai 200050, ChinaState Key Laboratory of Transducer Technology, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai 200050, ChinaState Key Laboratory of Transducer Technology, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai 200050, ChinaIn droplet-based microfluidics, visualizing and modulating of droplets is often prerequisite. In this paper, we report a facile strategy for visualizing and modulating high-throughput droplets in microfluidics. In the strategy, by modulating the sampling frequency of a flash light with the droplet frequency, we are able to map a real high frequency signal to a low frequency signal, which facilitates visualizing and feedback controlling. Meanwhile, because of not needing synchronization signals, the strategy can be directly implemented on any droplet-based microfluidic chips. The only cost of the strategy is an additional signal generator. Moreover, the strategy can catch droplets with frequency up to several kilohertz, which covers the range of most high-throughput droplet-based microfluidics. In this paper, the principle, setup and procedure were introduced. Finally, as a demonstration, the strategy was also implemented in a miniaturized picoinjector in order to monitor and control the injection dosage to droplets. We expect that this facile strategy supplies a low-cost yet effective imaging system that can be easily implemented in miniaturized microfluidic systems or general laboratories.https://www.mdpi.com/2072-666X/10/5/291microfluidicsdropletshigh-throughputmodulate |
| spellingShingle | Zehang Gao Huo Peng Minjie Zhu Lei Wu Chunping Jia Hongbo Zhou Jianlong Zhao A Facile Strategy for Visualizing and Modulating Droplet-Based Microfluidics Micromachines microfluidics droplets high-throughput modulate |
| title | A Facile Strategy for Visualizing and Modulating Droplet-Based Microfluidics |
| title_full | A Facile Strategy for Visualizing and Modulating Droplet-Based Microfluidics |
| title_fullStr | A Facile Strategy for Visualizing and Modulating Droplet-Based Microfluidics |
| title_full_unstemmed | A Facile Strategy for Visualizing and Modulating Droplet-Based Microfluidics |
| title_short | A Facile Strategy for Visualizing and Modulating Droplet-Based Microfluidics |
| title_sort | facile strategy for visualizing and modulating droplet based microfluidics |
| topic | microfluidics droplets high-throughput modulate |
| url | https://www.mdpi.com/2072-666X/10/5/291 |
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