Bacterial Infections Associated with Immunosuppressive Agents Commonly Used in Patients with Interstitial Lung Diseases
There are about 200 different types of interstitial lung disease (ILD), and a crucial initial step in the assessment of a patient with suspected ILD is achieving an appropriate diagnosis. Some ILDs respond to immunosuppressive agents, while immunosuppression can be detrimental in others, hence treat...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-03-01
|
| Series: | Pathogens |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-0817/12/3/464 |
| _version_ | 1827748163333652480 |
|---|---|
| author | Said Chaaban Ruxana T. Sadikot |
| author_facet | Said Chaaban Ruxana T. Sadikot |
| author_sort | Said Chaaban |
| collection | DOAJ |
| description | There are about 200 different types of interstitial lung disease (ILD), and a crucial initial step in the assessment of a patient with suspected ILD is achieving an appropriate diagnosis. Some ILDs respond to immunosuppressive agents, while immunosuppression can be detrimental in others, hence treatment is based on the most confident diagnosis with consideration of a patient’s risk factors. Immunosuppressive medications have the potential to result in substantial, and perhaps life-threatening, bacterial infections to a patient. However, data on the risk of bacterial infections from immunosuppressive treatment specifically in patients with interstitial lung disease is lacking. We hereby review the immunosuppressive treatments used in ILD patients excluding sarcoidosis, highlight their risk of bacterial infections, and discuss the potential mechanisms that contribute to the increased risk of infections. |
| first_indexed | 2024-03-11T06:03:25Z |
| format | Article |
| id | doaj.art-9863c5d16cae4815aa608143e82418a0 |
| institution | Directory Open Access Journal |
| issn | 2076-0817 |
| language | English |
| last_indexed | 2024-03-11T06:03:25Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj.art-9863c5d16cae4815aa608143e82418a02023-11-17T13:10:19ZengMDPI AGPathogens2076-08172023-03-0112346410.3390/pathogens12030464Bacterial Infections Associated with Immunosuppressive Agents Commonly Used in Patients with Interstitial Lung DiseasesSaid Chaaban0Ruxana T. Sadikot1Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198-6450, USAPulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198-6450, USAThere are about 200 different types of interstitial lung disease (ILD), and a crucial initial step in the assessment of a patient with suspected ILD is achieving an appropriate diagnosis. Some ILDs respond to immunosuppressive agents, while immunosuppression can be detrimental in others, hence treatment is based on the most confident diagnosis with consideration of a patient’s risk factors. Immunosuppressive medications have the potential to result in substantial, and perhaps life-threatening, bacterial infections to a patient. However, data on the risk of bacterial infections from immunosuppressive treatment specifically in patients with interstitial lung disease is lacking. We hereby review the immunosuppressive treatments used in ILD patients excluding sarcoidosis, highlight their risk of bacterial infections, and discuss the potential mechanisms that contribute to the increased risk of infections.https://www.mdpi.com/2076-0817/12/3/464interstitial lung diseaseimmunosuppressantspulmonary fibrosissarcoidosisinfectionreview |
| spellingShingle | Said Chaaban Ruxana T. Sadikot Bacterial Infections Associated with Immunosuppressive Agents Commonly Used in Patients with Interstitial Lung Diseases Pathogens interstitial lung disease immunosuppressants pulmonary fibrosis sarcoidosis infection review |
| title | Bacterial Infections Associated with Immunosuppressive Agents Commonly Used in Patients with Interstitial Lung Diseases |
| title_full | Bacterial Infections Associated with Immunosuppressive Agents Commonly Used in Patients with Interstitial Lung Diseases |
| title_fullStr | Bacterial Infections Associated with Immunosuppressive Agents Commonly Used in Patients with Interstitial Lung Diseases |
| title_full_unstemmed | Bacterial Infections Associated with Immunosuppressive Agents Commonly Used in Patients with Interstitial Lung Diseases |
| title_short | Bacterial Infections Associated with Immunosuppressive Agents Commonly Used in Patients with Interstitial Lung Diseases |
| title_sort | bacterial infections associated with immunosuppressive agents commonly used in patients with interstitial lung diseases |
| topic | interstitial lung disease immunosuppressants pulmonary fibrosis sarcoidosis infection review |
| url | https://www.mdpi.com/2076-0817/12/3/464 |
| work_keys_str_mv | AT saidchaaban bacterialinfectionsassociatedwithimmunosuppressiveagentscommonlyusedinpatientswithinterstitiallungdiseases AT ruxanatsadikot bacterialinfectionsassociatedwithimmunosuppressiveagentscommonlyusedinpatientswithinterstitiallungdiseases |