Forebrain Cholinergic Dysfunction and Systemic and Brain Inflammation in Murine Sepsis Survivors

Forebrain Cholinergic Dysfunction and Systemic and Brain Inflammation in Murine Sepsis Survivors

Sepsis, a complex disorder characterized by immune, metabolic, and neurological dysregulation, is the number one killer in the intensive care unit. Mortality remains alarmingly high even in among sepsis survivors discharged from the hospital. There is no clear strategy for managing this lethal chron...

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Bibliographic Details
Main Authors: Nahla Zaghloul, Meghan E. Addorisio, Harold A. Silverman, Hardik L. Patel, Sergio I. Valdés-Ferrer, Kamesh R. Ayasolla, Kurt R. Lehner, Peder S. Olofsson, Mansoor Nasim, Christine N. Metz, Ping Wang, Mohamed Ahmed, Sangeeta S. Chavan, Betty Diamond, Kevin J. Tracey, Valentin A. Pavlov
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-12-01
Series:Frontiers in Immunology
Subjects:
sepsis
sepsis survival
cytokines
inflammation
brain cholinergic system
neuroinflammation
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01673/full

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