Translocation Renal Cell Carcinoma: An Update on Clinicopathological and Molecular Features
Microphthalmia-associated transcription (MiT) family translocation renal cell carcinoma (tRCC) comprises Xp11 tRCC and t(6;11) RCC. Due to the presence of fusion genes, Xp11 tRCC and t(6;11) RCC are also known as TFE3- and TFEB-rearranged RCC, respectively. TFE3 and TFEB belong to the MiT family, wh...
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| Format: | Article |
| Language: | English |
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MDPI AG
2017-08-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/9/9/111 |
| _version_ | 1797766531210280960 |
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| author | Kentaro Inamura |
| author_facet | Kentaro Inamura |
| author_sort | Kentaro Inamura |
| collection | DOAJ |
| description | Microphthalmia-associated transcription (MiT) family translocation renal cell carcinoma (tRCC) comprises Xp11 tRCC and t(6;11) RCC. Due to the presence of fusion genes, Xp11 tRCC and t(6;11) RCC are also known as TFE3- and TFEB-rearranged RCC, respectively. TFE3 and TFEB belong to the MiT family, which regulates melanocyte and osteoclast differentiation, and TFE3- and TFEB-rearranged RCC show characteristic clinicopathological and immunohistochemical features. Recent studies identified the fusion partner-dependent clinicopathological and immunohistochemical features in TFE3-rearranged RCC. Furthermore, RCC with chromosome 6p amplification, including TFEB, was identified as a unique subtype of RCC, along with ALK-rearranged RCC. This review summarizes these recent advancements in our tRCC-related knowledge. |
| first_indexed | 2024-03-12T20:25:35Z |
| format | Article |
| id | doaj.art-9867ac368cef4bbb9dadb740c416a8cc |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-12T20:25:35Z |
| publishDate | 2017-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-9867ac368cef4bbb9dadb740c416a8cc2023-08-02T00:31:21ZengMDPI AGCancers2072-66942017-08-019911110.3390/cancers9090111cancers9090111Translocation Renal Cell Carcinoma: An Update on Clinicopathological and Molecular FeaturesKentaro Inamura0Division of Pathology, The Cancer Institute, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, Tokyo 135-8550, JapanMicrophthalmia-associated transcription (MiT) family translocation renal cell carcinoma (tRCC) comprises Xp11 tRCC and t(6;11) RCC. Due to the presence of fusion genes, Xp11 tRCC and t(6;11) RCC are also known as TFE3- and TFEB-rearranged RCC, respectively. TFE3 and TFEB belong to the MiT family, which regulates melanocyte and osteoclast differentiation, and TFE3- and TFEB-rearranged RCC show characteristic clinicopathological and immunohistochemical features. Recent studies identified the fusion partner-dependent clinicopathological and immunohistochemical features in TFE3-rearranged RCC. Furthermore, RCC with chromosome 6p amplification, including TFEB, was identified as a unique subtype of RCC, along with ALK-rearranged RCC. This review summarizes these recent advancements in our tRCC-related knowledge.https://www.mdpi.com/2072-6694/9/9/111ALKfusionkidneyrenal cell carcinomaTFE3TFEBtranslocation |
| spellingShingle | Kentaro Inamura Translocation Renal Cell Carcinoma: An Update on Clinicopathological and Molecular Features Cancers ALK fusion kidney renal cell carcinoma TFE3 TFEB translocation |
| title | Translocation Renal Cell Carcinoma: An Update on Clinicopathological and Molecular Features |
| title_full | Translocation Renal Cell Carcinoma: An Update on Clinicopathological and Molecular Features |
| title_fullStr | Translocation Renal Cell Carcinoma: An Update on Clinicopathological and Molecular Features |
| title_full_unstemmed | Translocation Renal Cell Carcinoma: An Update on Clinicopathological and Molecular Features |
| title_short | Translocation Renal Cell Carcinoma: An Update on Clinicopathological and Molecular Features |
| title_sort | translocation renal cell carcinoma an update on clinicopathological and molecular features |
| topic | ALK fusion kidney renal cell carcinoma TFE3 TFEB translocation |
| url | https://www.mdpi.com/2072-6694/9/9/111 |
| work_keys_str_mv | AT kentaroinamura translocationrenalcellcarcinomaanupdateonclinicopathologicalandmolecularfeatures |