TRPM Channels in Human Diseases
The transient receptor potential melastatin (TRPM) subfamily belongs to the TRP cation channels family. Since the first cloning of TRPM1 in 1989, tremendous progress has been made in identifying novel members of the TRPM subfamily and their functions. The TRPM subfamily is composed of eight members...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-12-01
|
| Series: | Cells |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4409/9/12/2604 |
| _version_ | 1827700768605470720 |
|---|---|
| author | Ivanka Jimenez Yolanda Prado Felipe Marchant Carolina Otero Felipe Eltit Claudio Cabello-Verrugio Oscar Cerda Felipe Simon |
| author_facet | Ivanka Jimenez Yolanda Prado Felipe Marchant Carolina Otero Felipe Eltit Claudio Cabello-Verrugio Oscar Cerda Felipe Simon |
| author_sort | Ivanka Jimenez |
| collection | DOAJ |
| description | The transient receptor potential melastatin (TRPM) subfamily belongs to the TRP cation channels family. Since the first cloning of TRPM1 in 1989, tremendous progress has been made in identifying novel members of the TRPM subfamily and their functions. The TRPM subfamily is composed of eight members consisting of four six-transmembrane domain subunits, resulting in homomeric or heteromeric channels. From a structural point of view, based on the homology sequence of the coiled-coil in the C-terminus, the eight TRPM members are clustered into four groups: TRPM1/M3, M2/M8, M4/M5 and M6/M7. TRPM subfamily members have been involved in several physiological functions. However, they are also linked to diverse pathophysiological human processes. Alterations in the expression and function of TRPM subfamily ion channels might generate several human diseases including cardiovascular and neurodegenerative alterations, organ dysfunction, cancer and many other channelopathies. These effects position them as remarkable putative targets for novel diagnostic strategies, drug design and therapeutic approaches. Here, we review the current knowledge about the main characteristics of all members of the TRPM family, focusing on their actions in human diseases. |
| first_indexed | 2024-03-10T14:19:37Z |
| format | Article |
| id | doaj.art-9867dbf1439143c18c8edd20acb235f5 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T14:19:37Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-9867dbf1439143c18c8edd20acb235f52023-11-20T23:31:58ZengMDPI AGCells2073-44092020-12-01912260410.3390/cells9122604TRPM Channels in Human DiseasesIvanka Jimenez0Yolanda Prado1Felipe Marchant2Carolina Otero3Felipe Eltit4Claudio Cabello-Verrugio5Oscar Cerda6Felipe Simon7Faculty of Life Science, Universidad Andrés Bello, Santiago 8370186, ChileFaculty of Life Science, Universidad Andrés Bello, Santiago 8370186, ChileFaculty of Life Science, Universidad Andrés Bello, Santiago 8370186, ChileFaculty of Medicine, School of Chemistry and Pharmacy, Universidad Andrés Bello, Santiago 8370186, ChileVancouver Prostate Centre, Vancouver, BC V6Z 1Y6, CanadaFaculty of Life Science, Universidad Andrés Bello, Santiago 8370186, ChileMillennium Nucleus of Ion Channel-Associated Diseases (MiNICAD), Universidad de Chile, Santiago 8380453, ChileFaculty of Life Science, Universidad Andrés Bello, Santiago 8370186, ChileThe transient receptor potential melastatin (TRPM) subfamily belongs to the TRP cation channels family. Since the first cloning of TRPM1 in 1989, tremendous progress has been made in identifying novel members of the TRPM subfamily and their functions. The TRPM subfamily is composed of eight members consisting of four six-transmembrane domain subunits, resulting in homomeric or heteromeric channels. From a structural point of view, based on the homology sequence of the coiled-coil in the C-terminus, the eight TRPM members are clustered into four groups: TRPM1/M3, M2/M8, M4/M5 and M6/M7. TRPM subfamily members have been involved in several physiological functions. However, they are also linked to diverse pathophysiological human processes. Alterations in the expression and function of TRPM subfamily ion channels might generate several human diseases including cardiovascular and neurodegenerative alterations, organ dysfunction, cancer and many other channelopathies. These effects position them as remarkable putative targets for novel diagnostic strategies, drug design and therapeutic approaches. Here, we review the current knowledge about the main characteristics of all members of the TRPM family, focusing on their actions in human diseases.https://www.mdpi.com/2073-4409/9/12/2604TRPM channelshuman diseasesion channels |
| spellingShingle | Ivanka Jimenez Yolanda Prado Felipe Marchant Carolina Otero Felipe Eltit Claudio Cabello-Verrugio Oscar Cerda Felipe Simon TRPM Channels in Human Diseases Cells TRPM channels human diseases ion channels |
| title | TRPM Channels in Human Diseases |
| title_full | TRPM Channels in Human Diseases |
| title_fullStr | TRPM Channels in Human Diseases |
| title_full_unstemmed | TRPM Channels in Human Diseases |
| title_short | TRPM Channels in Human Diseases |
| title_sort | trpm channels in human diseases |
| topic | TRPM channels human diseases ion channels |
| url | https://www.mdpi.com/2073-4409/9/12/2604 |
| work_keys_str_mv | AT ivankajimenez trpmchannelsinhumandiseases AT yolandaprado trpmchannelsinhumandiseases AT felipemarchant trpmchannelsinhumandiseases AT carolinaotero trpmchannelsinhumandiseases AT felipeeltit trpmchannelsinhumandiseases AT claudiocabelloverrugio trpmchannelsinhumandiseases AT oscarcerda trpmchannelsinhumandiseases AT felipesimon trpmchannelsinhumandiseases |