Brain-state-dependent constraints on claustrocortical communication and function
Summary: Neural activity in the claustrum has been associated with a range of vigilance states, yet the activity patterns and efficacy of synaptic communication of identified claustrum neurons have not been thoroughly determined. Here, we show that claustrum neurons projecting to the retrosplenial c...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-01-01
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| Series: | Cell Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124723016327 |
| _version_ | 1797371427233464320 |
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| author | Brian A. Marriott Alison D. Do Coline Portet Flora Thellier Romain Goutagny Jesse Jackson |
| author_facet | Brian A. Marriott Alison D. Do Coline Portet Flora Thellier Romain Goutagny Jesse Jackson |
| author_sort | Brian A. Marriott |
| collection | DOAJ |
| description | Summary: Neural activity in the claustrum has been associated with a range of vigilance states, yet the activity patterns and efficacy of synaptic communication of identified claustrum neurons have not been thoroughly determined. Here, we show that claustrum neurons projecting to the retrosplenial cortex are most active during synchronized cortical states such as non-rapid eye movement (NREM) sleep and are suppressed during increased cortical desynchronization associated with arousal, movement, and REM sleep. The efficacy of claustrocortical signaling is increased during NREM and diminished during movement due in part to increased cholinergic tone. Finally, claustrum activation during NREM sleep enhances memory consolidation through the phase resetting of cortical delta waves. Therefore, claustrocortical communication is constrained to function most effectively during cognitive processes associated with synchronized cortical states, such as memory consolidation. |
| first_indexed | 2024-03-08T18:18:45Z |
| format | Article |
| id | doaj.art-986bceb229894926ab7f575015c34d2e |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-03-08T18:18:45Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-986bceb229894926ab7f575015c34d2e2023-12-31T04:26:10ZengElsevierCell Reports2211-12472024-01-01431113620Brain-state-dependent constraints on claustrocortical communication and functionBrian A. Marriott0Alison D. Do1Coline Portet2Flora Thellier3Romain Goutagny4Jesse Jackson5Neuroscience and Mental Health Institute, University of Alberta, Edmonton, AB T6G2H7, CanadaDepartment of Physiology, University of Alberta, Edmonton, AB T6G2H7, CanadaUniversity of Strasbourg, Strasbourg, France; Laboratoire de Neurosciences Cognitives et Adaptatives, CNRS UMR7364, Strasbourg, FranceUniversity of Strasbourg, Strasbourg, France; Laboratoire de Neurosciences Cognitives et Adaptatives, CNRS UMR7364, Strasbourg, FranceUniversity of Strasbourg, Strasbourg, France; Laboratoire de Neurosciences Cognitives et Adaptatives, CNRS UMR7364, Strasbourg, France; Corresponding authorNeuroscience and Mental Health Institute, University of Alberta, Edmonton, AB T6G2H7, Canada; Department of Physiology, University of Alberta, Edmonton, AB T6G2H7, Canada; Corresponding authorSummary: Neural activity in the claustrum has been associated with a range of vigilance states, yet the activity patterns and efficacy of synaptic communication of identified claustrum neurons have not been thoroughly determined. Here, we show that claustrum neurons projecting to the retrosplenial cortex are most active during synchronized cortical states such as non-rapid eye movement (NREM) sleep and are suppressed during increased cortical desynchronization associated with arousal, movement, and REM sleep. The efficacy of claustrocortical signaling is increased during NREM and diminished during movement due in part to increased cholinergic tone. Finally, claustrum activation during NREM sleep enhances memory consolidation through the phase resetting of cortical delta waves. Therefore, claustrocortical communication is constrained to function most effectively during cognitive processes associated with synchronized cortical states, such as memory consolidation.http://www.sciencedirect.com/science/article/pii/S2211124723016327CP: Neuroscience |
| spellingShingle | Brian A. Marriott Alison D. Do Coline Portet Flora Thellier Romain Goutagny Jesse Jackson Brain-state-dependent constraints on claustrocortical communication and function Cell Reports CP: Neuroscience |
| title | Brain-state-dependent constraints on claustrocortical communication and function |
| title_full | Brain-state-dependent constraints on claustrocortical communication and function |
| title_fullStr | Brain-state-dependent constraints on claustrocortical communication and function |
| title_full_unstemmed | Brain-state-dependent constraints on claustrocortical communication and function |
| title_short | Brain-state-dependent constraints on claustrocortical communication and function |
| title_sort | brain state dependent constraints on claustrocortical communication and function |
| topic | CP: Neuroscience |
| url | http://www.sciencedirect.com/science/article/pii/S2211124723016327 |
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